Lung surfactant: some historical perspectives leading to its cellular and molecular biology

ACUTE RESPIRATORY DISTRESS IN ADULTS

1967 • 4,096 citations

Mechanical Properties of Lungs

1961 • 1,648 citations

Surface Properties in Relation to Atelectasis and Hyaline Membrane Disease

1959 • 1,495 citations

Treatment of the Idiopathic Respiratory-Distress Syndrome with Continuous Positive Airway Pressure

1971 • 1,181 citations

Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure.

1974 • 932 citations

ARTIFICIAL SURFACTANT THERAPY IN HYALINE-MEMBRANE DISEASE

1980 • 889 citations

PREMATURE DELIVERY OF FOETAL LAMBS INFUSED WITH GLUCOCORTICOIDS

1969 • 805 citations

Surface Tension of Lung Extracts

1957 • 563 citations

Pulmonary surface tension and alveolar stability

1961 • 417 citations

Metabolism and Turnover of Lung Surfactant

1987 • 412 citations

Relation of volume history of lungs to respiratory mechanics in anesthetized dogs

1959 • 411 citations

The pulmonary surfactant system: biochemical aspects and functional significance

1988 • 333 citations

In Vivo incorporation of choline‐³H, leucine‐³H and galactose‐³H in alveolar type II pneumocytes in relation to surfactant synthesis. A quantitative radioautographic study in mouse by electron microscopy

1972 • 302 citations

Properties, function, and origin of the alveolar lining layer

1958 • 301 citations

Conversion of lamellar body membranes into tubular myelin in alveoli of fetal rat lungs.

1977 • 297 citations

COMPOSITION OF SURFACE-ACTIVE MATERIAL ISOLATED FROM BEEF LUNG

1961 • 297 citations

Alveolar Epithelial Cell Mitochondria as Source of the Surface-Active Lung Lining

1962 • 241 citations

Electron microscopic demonstration of an extracellular duplex lining layer of alveoli

1968 • 239 citations

Subfractionation of lung surfactant implications for metabolism and surface activity

1983 • 234 citations

The interpretation and significance of the lecithin/sphingomyelin ratio in amniotic fluid

1974 • 226 citations

Lung Maturation in the Fetal Rat: Acceleration by Injection of Fibroblast-Pneumonocyte Factor

1979 • 213 citations

Ontogeny of tracheal fluid, pulmonary surfactant, and plasma corticoids in the fetal lamb

1975 • 209 citations

Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function

1976 • 195 citations

Time of Appearance of Lung Surfactant in the Fœtal Mouse

1962 • 185 citations

Effect of ventilation on surface forces in excised dogs' lungs.

1966 • 183 citations

Acceleration of appearance of pulmonary surfactant in the fetal lamb by administration of corticosteroids.

1970 • 183 citations

Correlations of Mechanical Stability, Morphology, Pulmonary Surfactant, and Phospholipid Content in the Developing Lamb Lung*

1967 • 175 citations

The Biochemical Development of Surface Activity in Mammalian Lung: I. The Surface-Active Phospholipids; the Separation and Distribution of Surface-Active Lecithin in the Lung of the Developing Rabbit Fetus

1967 • 175 citations

Lipoprotein Composition of the Film lining the Lung

1961 • 172 citations

Pulmonary surface film stability and composition

1979 • 169 citations

Pulmonary physiological and surfactant changes during injury and recovery from hyperoxia

1985 • 157 citations

Control of lung surfactant by ventilation, adrenergic mediators, and prostaglandins in the rabbit.

1978 • 148 citations

Cytochemistry of pulmonary alveolar epithelial cells.

1968 • 143 citations

Analysis of Labeling and Clearance of Lung Surfactant Phospholipids in Rabbit

1981 • 142 citations

A protein from airways of premature lambs that inhibits surfactant function

1984 • 139 citations

Pulmonary surfactant: an interdisciplinary approach

1984 • 127 citations

Phosphatidylglycerol in lung surfactant II. Subcellular distribution and mechanism of biosynthesis in vitro

1975 • 124 citations

Immunocytochemical localization and identification of the major surfactant protein in adult rat lung.

1981 • 123 citations

Effects of Tracheal Instillation of Natural Surfactant in Premature Lambs. I. Clinical and Autopsy Findings

1978 • 108 citations

Effect of surface active lipoprotein on clotting and fibrinolysis, and of fibrinogen on surface tension of surface active lipoprotein

1966 • 106 citations

Precursor-product relationship between rabbit type II cell lamellar bodies and alveolar surface-active material

1981 • 104 citations

Dipalmitoyl lecithin secretion and metabolism by the rat lung

1972 • 100 citations

Pulmonary alveolar proteinosis.

1967 • 95 citations

Respiratory distress and surfactant inhibition following vagotomy in rabbits

1986 • 91 citations

Lung Function in Prematurely Delivered Rabbits Treated with a Synthetic Surfactant

1987 • 91 citations

Phosphatidylglycerol-deficient lung surfactant has normal properties

1983 • 86 citations

INABILITY TO FORM A LUNG-LINING FILM AS A CAUSE OF THE RESPIRATORY-DISTRESS SYNDROME IN THE NEWBORN

1962 • 84 citations

Changes in Sedimentation of Surfactant in Ventilated Excised Rat Lungs

1979 • 77 citations

Cellular distribution and clearance of aerosolized dipalmitoyl lecithin

1975 • 73 citations

Method for Estimating Respiratory Surface Area of Mammalian Lungs from Their Physical Characteristics.

1954 • 66 citations

Intracellular metabolism of the apoproteins of pulmonary surfactant in rat lung

1980 • 59 citations

Impaired surfactant phospholipid metabolism in hyperoxic mouse lungs

1981 • 52 citations

What is the true role of surfactant in the lung?

1981 • 51 citations

Premature Science and Immature Lungs

1977 • 50 citations

Uptake of liposomal phosphatidylcholine by granular pneumocytes in primary culture

1983 • 48 citations

Changes in phospholipid composition of lung surfactant during development in the fetal lamb

1983 • 46 citations

THE EFFECT OF HYPERVENTILATION ON PULMONARY SURFACE ACTIVITY

1972 • 41 citations

Lung Area from Surface Tension Effects

1957 • 38 citations

Surfactant Synthesis, Secretion, and Function in Alveoli and Small Airways

1987 • 35 citations

Oxygen-induced changes in pulmonary phospholipids in the rat

1975 • 34 citations

Regulation of phosphatidylglycerol and phosphatidylinositol synthesis in alveolar type II cells isolated from adult rat lung

1982 • 30 citations

Alveolar phospholipids in pulmonary alveolar proteinosis.

1978 • 26 citations

Interspecies variation in lung lavage and tissue saturated phosphatidylcholine

1978 • 25 citations

Alterations in rat alveolar surfactant phospholipids and proteins induced by administration of chlorphentermine

1986 • 23 citations

Surfactant deficiency in rats without a decreased amount of extracellular surfactant.

1983 • 19 citations

Methylprednisolone Increases the Toxicity of Oxygen in Adult Mice

1984 • 18 citations

Premature science and immature lungs. Part I. Some premature discoveries.

1977 • 17 citations

A hypothesis relating breathing pattern to some forms of the “adult respiratory distress syndrome”

1980 • 15 citations

Premature science and immature lungs. Part II. Chemical warfare and the newly born.

1977 • 14 citations

Endobronchial surface active phospholipids in various pulmonary diseases.

1985 • 12 citations

Role of lymphatics in removal of sheep lung surfactant lipid

1983 • 10 citations