Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

2013 • 1,433 citations

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

2016 • 1,383 citations

Multiple organ infection and the pathogenesis of SARS

2005 • 1,372 citations

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

2008 • 1,280 citations

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome

2004 • 1,275 citations

Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus

2005 • 1,262 citations

Middle East respiratory syndrome

2015 • 1,243 citations

SARS: Systematic Review of Treatment Effects

2006 • 1,235 citations

Severe acute respiratory syndrome

2004 • 1,150 citations

Lung pathology of fatal severe acute respiratory syndrome

2003 • 1,101 citations

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

2003 • 1,051 citations

Age-dependent dysregulation of innate immunity

2013 • 937 citations

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

2012 • 936 citations

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

2015 • 867 citations

Therapeutic siRNA silencing in inflammatory monocytes in mice

2011 • 763 citations

Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame (ORF) 3b, ORF 6, and Nucleocapsid Proteins Function as Interferon Antagonists

2006 • 687 citations

An interferon‐γ‐related cytokine storm in SARS patients

2004 • 682 citations

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

2011 • 637 citations

Clinical Course and Outcomes of Critically Ill Patients With Middle East Respiratory Syndrome Coronavirus Infection

2014 • 569 citations

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

2014 • 546 citations

Severe Acute Respiratory Syndrome Coronavirus ORF6 Antagonizes STAT1 Function by Sequestering Nuclear Import Factors on the Rough Endoplasmic Reticulum/Golgi Membrane

2007 • 536 citations

Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study

2014 • 506 citations

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

2015 • 489 citations

Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia

2014 • 485 citations

Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia

2014 • 474 citations

A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice

2007 • 469 citations

Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells

2005 • 468 citations

Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

2016 • 460 citations

Cytokine Responses in Severe Acute Respiratory Syndrome Coronavirus-Infected Macrophages In Vitro: Possible Relevance to Pathogenesis

2005 • 452 citations

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques

2013 • 448 citations

Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

2008 • 444 citations

Acute Respiratory Distress Syndrome in Critically Ill Patients With Severe Acute Respiratory Syndrome

2003 • 435 citations

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

2015 • 423 citations

Rapid generation of a mouse model for Middle East respiratory syndrome

2014 • 421 citations

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

2013 • 420 citations

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

2012 • 417 citations

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

2015 • 416 citations

Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection

2013 • 392 citations

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

2013 • 391 citations

Human immunopathogenesis of severe acute respiratory syndrome (SARS)

2007 • 390 citations

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

2013 • 389 citations

Interferon-Mediated Immunopathological Events Are Associated with Atypical Innate and Adaptive Immune Responses in Patients with Severe Acute Respiratory Syndrome

2007 • 388 citations

Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014

2016 • 388 citations

Pegylated interferon-α protects type 1 pneumocytes against SARS coronavirus infection in macaques

2004 • 380 citations

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

2010 • 367 citations

Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity

2016 • 363 citations

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-κB Signaling

2009 • 361 citations

Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

2008 • 359 citations

Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of nsp1 and Rational Design of an Attenuated Strain

2007 • 353 citations

Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

2010 • 349 citations

Analysis of Serum Cytokines in Patients with Severe Acute Respiratory Syndrome

2004 • 346 citations

Adaptive immune cells temper initial innate responses

2007 • 341 citations

Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study

2014 • 331 citations

Characterization of Cytokine/Chemokine Profiles of Severe Acute Respiratory Syndrome

2005 • 319 citations

Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques

2013 • 311 citations

Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome

2005 • 305 citations

Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response

2016 • 295 citations

Significant Changes of Peripheral T Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome

2004 • 283 citations

Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels

2014 • 276 citations

The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists

2013 • 274 citations

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

2012 • 270 citations

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

2011 • 255 citations

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

2014 • 239 citations

Middle East Respiratory Syndrome Coronavirus: A Case-Control Study of Hospitalized Patients

2014 • 236 citations

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

2012 • 230 citations

Clinical Disease in Children Associated With Newly Described Coronavirus Subtypes

2006 • 230 citations

Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome

2006 • 228 citations

Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

2011 • 228 citations

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

2016 • 224 citations

SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism

2010 • 222 citations

High–Dose Pulse Versus Nonpulse Corticosteroid Regimens in Severe Acute Respiratory Syndrome

2003 • 216 citations

<scp>IFN</scp>λ is a potent anti‐influenza therapeutic without the inflammatory side effects of <scp>IFN</scp>α treatment

2016 • 212 citations

The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study

2004 • 210 citations

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

2015 • 209 citations

Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset

2014 • 207 citations

Aged BALB/c Mice as a Model for Increased Severity of Severe Acute Respiratory Syndrome in Elderly Humans

2005 • 206 citations

Initial viral load and the outcomes of SARS

2004 • 206 citations

Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

2013 • 203 citations

A mouse model for MERS coronavirus-induced acute respiratory distress syndrome

2016 • 203 citations

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

2015 • 203 citations

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

2016 • 191 citations

Animal models for SARS and MERS coronaviruses

2015 • 187 citations

Expression of Lymphocytes and Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome

2003 • 181 citations

Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

2015 • 178 citations

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

2009 • 175 citations

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

2017 • 173 citations

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

2010 • 163 citations

The Pathology and Pathogenesis of Experimental Severe Acute Respiratory Syndrome and Influenza in Animal Models

2014 • 157 citations

Interferon and cytokine responses to SARS-coronavirus infection

2008 • 154 citations

Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival

2014 • 154 citations

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

2015 • 151 citations

A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

2009 • 143 citations

Modeling the Early Events of Severe Acute Respiratory Syndrome Coronavirus Infection In Vitro

2006 • 137 citations

Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

2016 • 127 citations

Immunomodulatory therapy for severe influenza

2011 • 126 citations

Proliferative growth of SARS coronavirus in Vero E6 cells

2003 • 119 citations

High Secretion of Interferons by Human Plasmacytoid Dendritic Cells upon Recognition of Middle East Respiratory Syndrome Coronavirus

2015 • 118 citations

Receptor Variation and Susceptibility to Middle East Respiratory Syndrome Coronavirus Infection

2014 • 111 citations

Silencing of CCR2 in myocarditis

2014 • 111 citations

Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain

2014 • 108 citations

Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong

2006 • 103 citations

SARS: clinical virology and pathogenesis

2003 • 99 citations

Induction of Alternatively Activated Macrophages Enhances Pathogenesis during Severe Acute Respiratory Syndrome Coronavirus Infection

2012 • 96 citations

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

2016 • 93 citations

Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells

2015 • 90 citations

Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice

2008 • 86 citations

Coronavirus Host Range Expansion and Middle East Respiratory Syndrome Coronavirus Emergence: Biochemical Mechanisms and Evolutionary Perspectives

2015 • 85 citations

Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

2015 • 83 citations

Animal models of Middle East respiratory syndrome coronavirus infection

2015 • 71 citations

Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS

2005 • 69 citations

A probable role for IFN-γ in the development of a lung immunopathology in SARS

2005 • 61 citations

The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus

2016 • 58 citations

Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease

2015 • 51 citations

Transcriptomic Analysis Reveals a Mechanism for a Prefibrotic Phenotype in STAT1 Knockout Mice during Severe Acute Respiratory Syndrome Coronavirus Infection

2010 • 48 citations

Clinical spectrum of the Middle East respiratory syndrome coronavirus (MERS-CoV)

2016 • 47 citations

CORONAVIRUS-ASSOCIATED PNEUMONIA IN PREVIOUSLY HEALTHY CHILDREN

2007 • 35 citations

A cluster of patients with severe acute respiratory syndrome in a chest ward in southern Taiwan

2004 • 33 citations

Clinical and Laboratory Findings of SARS in Singapore

2006 • 32 citations

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