Deep sequencing of the TP53 gene reveals a potential risk allele for non–small cell lung cancer and supports the negative prognostic value of TP53 variants

Cancer statistics, 2016

2016 • 15,590 citations

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

2003 • 1,266 citations

Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

2011 • 923 citations

Role of p53 as a prognostic factor for survival in lung cancer: a systematic review of the literature with a meta-analysis

2001 • 409 citations

Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis.

2000 • 300 citations

p53 mRNA controls p53 activity by managing Mdm2 functions

2008 • 226 citations

p53 Mutations and Survival in Stage I Non-Small-Cell Lung Cancer: Results of a Prospective Study

2003 • 209 citations

Prognostic value ofTP53,KRASandEGFRmutations in nonsmall cell lung cancer: the EUELC cohort

2012 • 97 citations

Prognostic and Predictive Effect of TP53 Mutations in Patients with Non–Small Cell Lung Cancer from Adjuvant Cisplatin–Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis

2016 • 85 citations

Association of DNA Repair Gene Polymorphisms With Response to Platinum-Based Doublet Chemotherapy in Patients With Non–Small-Cell Lung Cancer

2010 • 78 citations

TP53 and MDM2 genetic alterations in non-small cell lung cancer: Evaluating their prognostic and predictive value

2015 • 74 citations

Association ofp53codon 72 polymorphism andMDM2SNP309 with clinical outcome of advanced nonsmall cell lung cancer

2008 • 73 citations

VariantDB: a flexible annotation and filtering portal for next generation sequencing data

2014 • 64 citations

APR-246 (PRIMA-1 MET ) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines

2016 • 56 citations

Prognostic markers in lung cancer: is it ready for prime time?

2014 • 51 citations

Growing clinical evidence for the interaction of the p53 genotype and response to induction chemotherapy in advanced non–small cell lung cancer

2008 • 49 citations

Combined Effect of Genetic Polymorphisms in P53, P73, and MDM2 on Non-small Cell Lung Cancer Survival

2011 • 39 citations

Significance of TP53 mutations as predictive markers of adjuvant cisplatin‐based chemotherapy in completely resected non‐small‐cell lung cancer

2014 • 39 citations

Survival in operable non-small-cell lung cancer: Role of p53 mutations, tobacco smoking and asbestos exposure

2000 • 35 citations

MUT-TP53 2.0: a novel versatile matrix for statistical analysis of TP53 mutations in human cancera

2010 • 28 citations

Potential Increase in the Prognostic Value of p53 Mutation by Pro72 Allele in Stage I Non-Small-Cell Lung Cancer

2009 • 12 citations

Allelic Expression Imbalance ofTP53Mutated and Polymorphic Alleles in Head and Neck Tumors

2011 • 11 citations