Regulation of the Protein-Synthesizing Machinery—Ribosomes, tRNA, Factors, and So On

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Two Compounds implicated in the Function of the RC Gene of Escherichia coli

1969 • 750 citations

A MULTIPLE RIBOSOMAL STRUCTURE IN PROTEIN SYNTHESIS

1963 • 575 citations

Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes

1973 • 466 citations

Patterns of protein synthesis in E. coli: a catalog of the amount of 140 individual proteins at different growth rates

1978 • 398 citations

The Adaptive Responses of Escherichia coli to a Feast and Famine Existence

1971 • 393 citations

The Transition Between Different Physiological States During Balanced Growth of Salmonella typhimurium

1958 • 387 citations

Regulation of ribosomal and transfer RNA synthesis

1962 • 307 citations

On the Regulation of Guanosine Tetraphosphate Levels in Stringent and Relaxed Strains of Escherichia coli

1971 • 288 citations

Nonsense codons and polarity in the tryptophan operon

1966 • 284 citations

SEQUENTIAL REPLICATION OF BACILLUS SUBTILIS CHROMOSOME, I. COMPARISON OF MARKER FREQUENCIES IN EXPONENTIAL AND STATIONARY GROWTH PHASES

1963 • 248 citations

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency.

1975 • 240 citations

Growth rate of polypeptide chains as a function of the cell growth rate in a mutant of Escherichia coli 15

1971 • 218 citations

Regulation of ribosome production in Escherichia coli: Synthesis and stability of ribosomal RNA and of ribosomal protein messenger RNA at different growth rates

1977 • 204 citations

The amino acid sequence of beta-galactosidase of Escherichia coli.

1977 • 176 citations

Autorepressor Model for Control of DNA Replication

1973 • 175 citations

Intermediates and time kinetics of the in vivo assembly of Escherichia coli ribosomes

1975 • 169 citations

Control of production of ribosomal protein

1967 • 166 citations

Interaction of RNA Polymerase with Promoters from Bacteriophage fd

1977 • 156 citations

Protein Degradation in Escherichia coli

1970 • 156 citations

Biosynthesis of RNA polymerase in Escherichia coli

1974 • 153 citations

Accumulation and turnover of guanosine tetraphosphate in Escherichia coli

1972 • 145 citations

Residual RNA Synthesis in Escherichia coli after Inhibition of Initiation of Transcription by Rifampicin

1970 • 143 citations

Functional mRNA half lives in E. coli

1978 • 131 citations

Indices of Discriminability

1973 • 128 citations

Codon specific, tRNA dependent in vitro synthesis of ppGpp and pppGpp.

1973 • 125 citations

Biosynthetic regulation of individual proteins in relA + and relA strains of Escherichia coli during amino acid starvation

1976 • 117 citations

RNA polymerase specificity and the control of growth

1976 • 111 citations

Modulation of RNA polymerase specificity by ppGpp

1976 • 110 citations

Stringent Control of Ribosomal Protein Gene Expression in Escherichia coli

1974 • 108 citations

Replication of R-factor R1 in Scherichia coli K-12 at different growth rates

1975 • 108 citations

Simple downshift and resulting lack of correlation between ppGpp pool size and ribonucleic acid accumulation

1975 • 102 citations

Properties of a bacterial mutant lacking amino acid control of RNA synthesis

1963 • 102 citations

Regulation of the in vivo synthesis of the polypeptide chain elongation factors in Escherichia coli

1970 • 101 citations

MESSENGER-RNA ATTACHMENT TO ACTIVE RIBOSOMES

1962 • 100 citations

Histidine regulation in Salmonella typhimurium: an activator attenuator model of gene regulation.

1975 • 99 citations

Anomalous synthesis of ppGpp in growing cells

1977 • 98 citations

The effect of gene concentration and relative gene dosage on gene output inEscherichia coli

1975 • 97 citations

Effect of growth rate on the relative rates of synthesis of messenger, ribosomal and transfer RNA in Escherichia coli

1972 • 95 citations

Cluster of genes in Escherichia coli for ribosomal proteins, ribosomal RNA, and RNA polymerase subunits.

1975 • 95 citations

An Analysis of Bacterial Growth

1970 • 90 citations

Initiation of transcription by Escherichia coli RNA polymerase from supercoiled and non-supercoiled bacteriophage PM2 DNA

1975 • 87 citations

The periodicity of RNA polymerase initiations: a new regulatory feature of transcription.

1968 • 83 citations

STUDIES ON A MUTANT OF ESCHERICHIA COLI WITH UNBALANCED RIBONUCLEIC ACID SYNTHESIS

1956 • 81 citations

Chain elongation rate of messenger and polypeptides in slowly growing Escherichia coli

1971 • 78 citations

Sequential biosynthesis of the β and β′ subunits of the DNA-dependent RNA polymerase from Escherichia coli

1971 • 77 citations

Steady-State Measurement of the Turnover of Amino Acid in the Cellular Proteins of Growing Escherichia coli : Existence of Two Kinetically Distinct Reactions

1970 • 77 citations

THE ACCUMULATION OF RIBONUCLEIC ACID BY A MUTANT OF ESCHERICHIA COLI

1963 • 77 citations

Control of Protein Synthesis in Escherichia coli : Analysis of an Energy Source Shift-Down

1977 • 76 citations

Transport-Limited Growth Rates in a Mutant of Escherichia coli

1971 • 74 citations

Regulation of Biosynthesis of Ribosomes

1974 • 72 citations

In vivo assay of protein synthesizing capacity of Escherichia coli from slowly growing chemostat cultures

1971 • 72 citations

Messenger Ribonucleic Acid Synthesis and Degradation in Escherichia coli During Inhibition of Translation

1973 • 70 citations

Ribosomal protein in E. coli: Rate of synthesis and pool size at different growth rates

1974 • 69 citations

Synthesis time of β-galactosidase in Escherichia coli B/r as a function of growth rate

1975 • 67 citations

Synthesis and turnover of basal level guanosine tetraphosphate in Escherichia coli.

1975 • 67 citations

Genetic transcription

1966 • 63 citations

Efficiency of protein and messenger RNA synthesis in bacteriophage T4-infected cells of Escherichia coli

1972 • 63 citations

Effect of ribosomes on the biosynthesis of ribonucleic acid in vitro

1966 • 63 citations

Heterogeneity of ribosomal populations in Escherichia coli cells grown in different media

1972 • 62 citations

Regulation of messenger RNA synthesis in Escherichia coli

1968 • 55 citations

Organization of bacterial genes for ribosomal components: Studies using novel approaches

1976 • 53 citations

The competitive inhibition of α-methylglucoside uptake in Escherichiacoli

1963 • 53 citations

Different half-lives of messenger RNA corresponding to different segments of the tryptophan operon of Escherichia coli

1972 • 53 citations

Metabolic regulation of the tryptophan operon of Escherichia coli: Repressor-independent regulation of transcription initiation frequency

1972 • 52 citations

Origin of chloramphenicol particle protein

1968 • 46 citations

Regulation of transcription factor rho and the alpha subunit of RNA polymerase in Escherichia coli B/r.

1976 • 45 citations

Resistance of Escherichia coli to Penicillins VII. Purification and Characterization of a Penicillinase Mediated by the R Factor R1

1970 • 45 citations

The effects of fusidic acid on growth, ribosome synthesis and RNA metabolism in Escherichia coli

1974 • 42 citations

Chain growth rate of β-galactosidase during exponential growth and amino acid starvation

1973 • 41 citations

Activation of transcription by guanosine 5'-diphosphate,3'-diphosphate, transfer ribonucleic acid, and novel protein from Escherichia coli.

1975 • 37 citations

Evidence for variable rates of ribosome movement in Escherichia coli

1976 • 36 citations

Regulation of Nucleic Acid and Protein Formation in Bacteria

1967 • 34 citations

On the initiation of transcription of the tryptophan operon in Escherichia coli.

1968 • 33 citations

Identification of genes for elongation factor Ts and ribosomal protein S2 in E. coli

1976 • 32 citations

Metabolic regulation of β-galactosidase synthesis in Escherichia coli. A test for constitutive ribosome synthesis

1975 • 31 citations

Intracistronic polarity during dissociation of translation from transcription in Escherichia coli

1973 • 29 citations

Specific binding of formylated initiator-tRNA to Escherichia coli RNA polymerase.

1976 • 29 citations

In vivo experiments on the mechanism of action of l-arabinose C gene activator and lactose repressor

1973 • 28 citations

Initiation of Transcription within an RNA‐Polymerase Binding Site

1975 • 25 citations

Electron microscopy of gene regulation: The <scp>L</scp> -arabinose operon

1976 • 20 citations

Protein synthesis in a relaxed-control mutant of Escherichia coli upon recovery from methionine starvation

1966 • 18 citations

Evidence against transcription termination within the E. coli lac operon

1974 • 17 citations

Purification and properties of M protein: an accessory factor for RNA polymerase

1973 • 16 citations

Regulation of Pyruvate Dehydrogenase Synthesis: Substrate Induction

1968 • 15 citations

Regulation of ribosomal protein synthesis in Escherichia coli B/r

1975 • 14 citations

The simultaneous accumulation of RNA and of a repressor of β-galactosidase synthesis

1962 • 12 citations

Stimulation of lac Transcription by Guanosine 5′-Diphosphate 2′(or 3′)-Diphosphate and Transfer Ribonucleic Acid

1973 • 11 citations

Regulatory state of ribosomal genes and physiological changes in the concentration of free ribonucleic acid polymerase in Escherichia coli

1975 • 10 citations

Chapter VI: Transcription of the Lactose Operon in E. coli

1970 • 9 citations

Measurement of the pool size and synthesis rate of the metabolically unstable fraction of RNA in Escherichia coli by a method independent of hybridization efficiency and unaffected by precursor compartmentation

1976 • 7 citations

Synthesis of ribosomal protein during the cell cycle of Escherichia coli B/r

1974 • 5 citations

EARLY STEPS IN THE FORMATION OF A TRANSLATION INITIATION COMPLEX ON NEWLY TRANSCRIBED MESSENGER RNA

1973 • 2 citations