Molecular Cytogenetics of Renal Cell Tumors

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Clinical Features and Natural History of von Hippel-Lindau Disease

1990 • 916 citations

Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis

1990 • 773 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Constitutive Fragile Sites and Cancer

1984 • 693 citations

The role of gene dosage and genetic transpositions in carcinogenesis

1981 • 670 citations

Von Hippel–Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

1988 • 661 citations

Hereditary Renal-Cell Carcinoma Associated with a Chromosomal Translocation

1979 • 649 citations

Nephrogenic Rests, Nephroblastomatosis, and the Pathogenesis of Wilms' Tumor

1990 • 643 citations

Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma

1987 • 638 citations

An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region

1989 • 637 citations

Mechanisms of Tumor Progression

2010 • 608 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

1990 • 456 citations

Abnormal sexual differentiation and neoplasia

1987 • 386 citations

Von Hippel-Lindau Disease Affecting 43 Members of a Single Kindred

1989 • 369 citations

Chromophobe cell renal carcinoma and its variants—a report on 32 cases

1988 • 348 citations

Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma.

1988 • 343 citations

Cytogenetics of papillary renal cell tumors

1991 • 332 citations

Fragile sites on human chromosomes

1985 • 316 citations

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

1990 • 292 citations

Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7

1990 • 270 citations

Familial Renal Cell Carcinoma with a 3;11 Chromosome Translocation Limited to Tumor Cells

1982 • 260 citations

Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11

1988 • 252 citations

Molecular differential pathology of renal cell tumours

1993 • 247 citations

Fragile Sites on Human Chromosomes

1986 • 242 citations

Involvement of chromosome X in primary cytogenetic change in human neoplasia: nonrandom translocation in synovial sarcoma.

1987 • 237 citations

Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas.

1989 • 229 citations

Accumulation of genetic alterations and progression of primary breast cancer.

1991 • 229 citations

Hypervariable minisatellite DNA is a hotspot for homologous recombination in human cells

1990 • 226 citations

Specific Genetic Change in Tumors Associated With von Hippel-Lindau Disease

1989 • 222 citations

Lack of linkage of familial Wilms' tumour to chromosomal band 11 p13

1988 • 215 citations

Histopathological, cytogenetic, and molecular characterization of renal cortical tumors.

1991 • 210 citations

Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.

1991 • 207 citations

Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy.

1991 • 204 citations

A third Wilms' tumor locus on chromosome 16q.

1992 • 201 citations

Cytological Evidence for Crossing-Over in vitro in Human Lymphoid Cells

1964 • 196 citations

Specific chromosome aberration in human renal cell carcinoma

1987 • 195 citations

i(12p): Specific chromosomal marker in seminoma and malignant teratoma of the testis?

1983 • 189 citations

Molecular analysis of genetic changes in the origin and development of renal cell carcinoma.

1991 • 181 citations

Papillary renal cell carcinoma. A morphologic and cytogenetic study of 11 cases.

1989 • 178 citations

Cytogenetic studies of tumor tissue from patients with nonfamilial renal cell carcinoma.

1986 • 176 citations

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

1976 • 166 citations

Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas.

1992 • 161 citations

Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3

1990 • 154 citations

Common regions of deletion on chromosomes 5q, 6q, and 10q in renal cell carcinoma.

1991 • 154 citations

Trisomy 7 and sex chromosome loss in human brain tissue

1989 • 152 citations

Low chromosome number in chromophobe renal cell carcinomas

1992 • 148 citations

A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma.

1991 • 145 citations

Tissue‐specific expression of a constitutional 3;6 translocation: Development of multiple bilateral renal‐cell carcinomas

1989 • 142 citations

Deletion mapping in human renal cell carcinoma.

1989 • 135 citations

Trisomy 7, trisomy 10, and loss of the Y chromosome in short-term cultures of normal kidney tissue

1990 • 133 citations

Renal pathology in von Hippel-Lindau disease

1988 • 131 citations

Translocation (X;1) in papillary renal cell carcinoma a new cytogenetic subtype

1993 • 131 citations

Involvement of chromosome 7 in primary lung tumor and nonmalignant normal lung tissue

1989 • 131 citations

Cytogenetic analysis of six renal oncocytomas and a chromophobe cell renal carcinoma

1992 • 125 citations

Chromosomes in kidney, ureter, and bladder cancer

1986 • 124 citations

Involvement of band 3p14 in t(3;8) hereditary renal carcinoma

1984 • 123 citations

Allelic deletions in the long arm of chromosome 12 identify sites of candidate tumor suppressor genes in male germ cell tumors.

1992 • 116 citations

Cytogenetics of a renal adenocarcinoma in a 2-year-old child

1986 • 115 citations

Chromosome error propagation and cancer

1989 • 114 citations

Cytogenetics of a renal cell carcinoma in a 17-month-old child

1991 • 112 citations

Spontaneous neoplastic evolution of Chinese hamster cells in culture: multistep progression of karyotype.

1983 • 111 citations

Mitochondrial and chromosomal DNA alterations in human chromophobe renal cell carcinomas

1992 • 107 citations

Differentiation Between Papillary and Nonpapillary Renal Cell Carcinomas by DNA Analysis

1989 • 104 citations

Correlation of chromosome abnormalities with histological and clinical features in Wilms' and other childhood renal tumors.

1991 • 103 citations

Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line YCR.

1990 • 99 citations

Abnormalities at chromosome region 3p12–14 characterize clear cell renal carcinoma

1987 • 99 citations

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors.

1990 • 98 citations

Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions

1989 • 96 citations

Alteration of mitochondrial DNA in human oncocytomas

1989 • 96 citations

Cloning and characterization of a gene that regulates cell adhesion

1992 • 96 citations

Wilms' tumor in the adult patient. Diagnosis, management, and review of the world medical literature

1980 • 96 citations

Genetically determined chromosome instability syndromes

1982 • 93 citations

Molecular evidence that homologous recombination occurs in proliferating human somatic cells.

1990 • 93 citations

Hotspots of homologous recombination in mammalian genomes

1987 • 92 citations

Chromosomal patterns in human benign uterine leiomyomas

1990 • 86 citations

Chromophobe Cell Carcinoma

1990 • 83 citations

Clinical and Genetic Studies of Renal Cell Carcinomas in a Family with a Constitutional Chromosome 3; 8 Translocation: Genetics of Familial Renal Carcinoma

1993 • 83 citations

Nonhomologous chromatid exchange in hereditary and sporadic renal cell carcinomas.

1991 • 82 citations

A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5

1992 • 81 citations

[Cancer of the kidney].

1950 • 80 citations

Amplification and overexpression of the epidermal growth factor receptor gene in human renal‐cell carcinoma

1990 • 79 citations

Inverse relationship of epidermal growth factor receptor and HER2/neu gene expression in human renal cell carcinoma.

1990 • 77 citations

A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma

1990 • 76 citations

Cytogenetics of renal cell carcinomas associated with von hippel‐Lindau disease

1991 • 74 citations

Renal cell carcinoma in children

1983 • 74 citations

The Genetics of Wilms' Tumor

1992 • 73 citations

Aberrant expression of epidermal growth factor receptor and HER-2 (erbB-2) messenger RNAs in human renal cancers.

1989 • 70 citations

Epidemiologic studies on carcinoma of the kidney.I. Association of renal adenocarcinoma with smoking

1968 • 68 citations

Renal oncocytoma. A phenotypic and genotypic entity of renal parenchymal tumors.

1989 • 67 citations

Further Evidence that Renal Oncocytoma has Malignant Potential

1988 • 67 citations

Cytogenetics of 12 cases of renal adenocarcinoma

1988 • 66 citations

Binucleated cells in a human renal cell carcinoma with 34 chromosomes

1988 • 64 citations

Tandem duplication q14 and dicentric formation by end-to-end chromosome fusions in ataxia telangiectasia (AT)

1975 • 63 citations

Renal Adenomas in Hypernephromatous Kidneys: A Study of their Incidence, Nature and Relationship

1946 • 62 citations

Proximal 3p deletion in renal cell carcinoma cells from a patient with von Hippel-Lindau disease

1987 • 62 citations

Clonal aberrations of chromosomes x, y, 7 and 10 in normal kidney tissue of patients with renal cell tumors

1992 • 60 citations

Telomeric association in two human renal tumors

1987 • 59 citations

Nonlinkage of 16q markers to familial predisposition to Wilms' tumor.

1992 • 59 citations

The cytogenetics of renal tumors

1989 • 55 citations

Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p.

1989 • 54 citations

On the significance of trisomy 7 and sex chromosome loss in renal cell carcinoma

1990 • 54 citations

Cytogenetic, flow cytometric, and ultrastructural studies of twenty-nine nonfamilial human renal carcinomas.

1988 • 53 citations

Renal oncocytoma a cytogenetic and morphologic study

1987 • 52 citations

Renal Cortical Tumors: Cytogenetic Characterization

1989 • 50 citations

The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB

1991 • 47 citations

The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase.

1991 • 47 citations

Cytogenetic abnormalities in renal oncocytic neoplasms

1992 • 46 citations

Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: A strategy for cloning the putative tumor suppressor gene

1992 • 44 citations

Application of molecular cytogenetic techniques to the evaluation of renal parenchymal tumors

1990 • 43 citations

Triplication of one chromosome no. 15 with an altered C‐myc containing ecori fragment and elimination of the normal homologue in a T‐cell lymphoma line of akr origin (TIKAUT)

1984 • 41 citations

Cytogenetic characterization of renal cell carcinoma in von Hippel-Lindau syndrome

1990 • 41 citations

Familial renal carcinoma

1982 • 40 citations

Involvement of chromosomes 3 and 5 in renal cell carcinoma

1988 • 39 citations

Consistent Chromosome Abnormalities Associated With Mouse Bladder Epithelial Cell Lines Transformed In Vitro

1980 • 38 citations

Allelic losses at chromosome 17p in human renal cell carcinoma are inversely related to allelic losses at chromosome 3p.

1992 • 37 citations

Cytogenetic abnormalities in tumors of patients with von hippel-lindau disease

1989 • 36 citations

Cytogenetic Abnormalities Associated with Renal Cell Carcinoma

1991 • 35 citations

3p involvement in a renal cell carcinoma in von Hippel-Lindau syndrome

1988 • 32 citations

Conformational mutations in human mitochondrial DNA

1987 • 31 citations

A gene near the D3F15S2 site on 3p is expressed in normal human kidney but not or only at a severely reduced level in 11 of 15 primary renal cell carcinomas (RCC).

1990 • 31 citations

Genome imprinting, cellular mosaicism and carcinogenesis

1990 • 30 citations

Genomic defects in nonfamilial renal cell carcinoma

1988 • 30 citations

Molecular Analysis of the Short Arm of Chromosome 3 in Five Renal Oncocytomas

1990 • 23 citations

Chromosomal changes in renal cell carcinoma

1990 • 23 citations

Recurrent genomic rearrangements are not at the fragile sites on chromosomes 3 and 5 in human renal cell carcinomas

1988 • 19 citations

Altered dosage of the sex chromosomes in human testicular cancer: A molecular genetic study

1991 • 18 citations

Detailed mapping around the breakpoint of (3;8) translocation in familial renal cell carcinoma and FRA3B

1992 • 16 citations

Loss of common 3p14 fragile site expression in renal cell carcinoma with deletion breakpoint at 3p14

1988 • 14 citations

Benign epithelial nephroblastoma

1977 • 13 citations

Persistent renal blastema in an adult

1984 • 13 citations

Localization by in situ hybridization of three 3p probes with respect to the breakpoint in a t(3;8) in hereditary renal cell carcinoma

1991 • 5 citations

Molecular analysis of the chromosome 11p region in renal cell carcinomas.

1992 • 3 citations

Cytogenetic findings in a patient with renal cell adenocarcinomas and an oncotytic tumor

1991 • 1 citations