Use of epitope libraries to identify exon-specific monoclonal antibodies for characterization of altered dystrophins in muscular dystrophy.

The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein

1988 • 1,501 citations

Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification

1988 • 1,260 citations

The Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation

1989 • 1,171 citations

The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion.

1989 • 940 citations

Characterization of Dystrophin in Muscle-Biopsy Specimens from Patients with Duchenne's or Becker's Muscular Dystrophy

1988 • 910 citations

Very mild muscular dystrophy associated with the deletion of 46% of dystrophin

1990 • 578 citations

Construction of a new family of high efficiency bacterial expression vectors: identification of cDNA clones coding for human liver proteins.

1984 • 538 citations

An autosomal transcript in skeletal muscle with homology to dystrophin

1989 • 478 citations

Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation

1992 • 429 citations

Detailed analysis of the repeat domain of dystrophin reveals four potential hinge segments that may confer flexibility.

1990 • 384 citations

Exploring the molecular basis for variability among patients with Becker muscular dystrophy: dystrophin gene and protein studies.

1991 • 374 citations

Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP–binding domains

1989 • 357 citations

Alternative splicing of human dystrophin mRNA generates isoforms at the carboxy terminus

1989 • 332 citations

Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines.

1991 • 258 citations

A 71-kilodalton protein is a major product of the Duchenne muscular dystrophy gene in brain and other nonmuscle tissues.

1992 • 234 citations

Duchenne muscular dystrophy gene product is not identical in muscle and brain

1989 • 230 citations

Preferential deletion of exons in Duchenne and Becker muscular dystrophies

1987 • 201 citations

Point mutations in the dystrophin gene.

1992 • 189 citations

Direct detection of dystrophin gene rearrangements by analysis of dystrophin mRNA in peripheral blood lymphocytes.

1991 • 165 citations

Somatic reversion/suppression in Duchenne muscular dystrophy (DMD): evidence supporting a frame-restoring mechanism in rare dystrophin-positive fibers.

1992 • 135 citations

Characterization of a 4.8kb transcript from the Duchenne muscular dystrophy locus expressed in Schwannoma cells

1992 • 119 citations

pUEX, a bacterial expression vector related to pEX with universal host specificity

1987 • 113 citations

Efficient construction of cDNA libraries in plasmid expression vectors using an adaptor strategy

1986 • 102 citations

Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes.

1987 • 101 citations

Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy

1991 • 92 citations

Determination of the exon structure of the distal portion of the dystrophin gene by vectorette PCR

1992 • 90 citations

Dystrophin in frameshift deletion patients with Becker muscular dystrophy.

1992 • 73 citations

A truncated dystrophin lacking the C-terminal domains is localized at the muscle membrane.

1992 • 71 citations

Point mutation in the human dystrophin gene: Identification through Western blot analysis

1991 • 68 citations

Structural predictions for the central domain of dystrophin

1990 • 64 citations

Detection of a specific isoform of alpha-actinin with antisera directed against dystrophin.

1989 • 46 citations

Patterns of exon deletions in Duchenne and Becker muscular dystrophy

1988 • 43 citations

Monoclonal antibodies for dystrophin analysis. Epitope mapping and improved binding to SDS-treated muscle sections

1992 • 41 citations

Rapid mapping by transposon mutagenesis of epitopes on the muscular dystrophy protein, dystrophin

1991 • 26 citations

Monoclonal antibody evidence for structural similarities between the central rod regions of actinin and dystrophin

1990 • 23 citations