Isolation and Characterization of Low Density Lipoproteins

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Methods of Biochemical Analysis

1956 • 4,535 citations

Protein Purification by Affinity Chromatography

1970 • 2,809 citations

A new method for the direct determination of serum cholesterol.

1953 • 2,530 citations

Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions

1970 • 2,523 citations

Preparation and Properties of Serum and Plasma Proteins. IV. A System for the Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids^1a,b,c,d

1946 • 1,815 citations

Protides of the Biological Fluids

1969 • 1,623 citations

Practical Methods for Plasma Lipoprotein Analysis1 1Work supported in part by the U.S. Atomic Energy Commission and by grants (HE06222 and FR00102) from the U.S. Public Health Service.

1968 • 1,255 citations

Ann Arbor, Michigan

1969 • 1,061 citations

The Role of Lipids and Lipoproteins in Atherosclerosis

1950 • 808 citations

A specific apoprotein activator for lipoprotein lipase

1970 • 665 citations

Sur un dosage rapide du cholesterol lié aux α-et aux β-lipoprotéines du sérum

1960 • 634 citations

Advances in Biological and Medical Physics

1954 • 545 citations

Blood Lipids and Lipoproteins: Quantitation, Composition and Metabolism

1973 • 543 citations

The Familial Hyperlipoproteinemias

1975 • 538 citations

Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein

1972 • 497 citations

Sharper separation of lipoprotein species by paper electrophoresis in albumin-containing buffer.

1963 • 495 citations

The Metabolic Role of Lecithin: Cholesterol Acyltransferase: Perspectives from Pathology

1973 • 480 citations

Studies of the Proteins in Human Plasma Very Low Density Lipoproteins

1969 • 467 citations

Ultracentrifugal Analysis of Serum Lipoproteins

1954 • 418 citations

Blood Lipids and Human Atherosclerosis

1950 • 417 citations

The Separation of the Antibodies, Isoagglutinins, Prothrombin, Plasminogen and β₁-Lipoprotein into Subfractions of Human Plasma

1949 • 412 citations

Blood lipids and lipoproteins; quantitation, composition and metabolism

1973 • 400 citations

Physical-chemical Characteristics of Certain of the Proteins of Normal Human Plasma.

1947 • 368 citations

Structural and functional aspects of lipoproteins in living systems.

1969 • 360 citations

Protein-lipid relationships in human plasma

1951 • 356 citations

BILATERAL ZOSTER

1947 • 322 citations

Role of Specific Glycopeptides of Human Serum Lipoproteins in the Activation of Lipoprotein Lipase

1970 • 312 citations

Lipid composition of human serum lipoproteins

1967 • 295 citations

Studies on the composition and structure of plasma lipoproteins. Distribution of lipoprotein families in major density classes of normal human plasma lipoproteins.

1972 • 287 citations

ULTRACENTRIFUGAL STUDIES OF LIPOPROTEINS OF HUMAN SERUM

1949 • 282 citations

Amino Acid Sequence of Human apoLp-Gln-II (apoA-II), an Apolipoprotein Isolated from the High-Density Lipoprotein Complex

1972 • 278 citations

The transport of vitamin A and carotenoids in human plasma

1958 • 277 citations

Lipoprotein-Polyanion-Metal Interactions1 1This investigation was supported in part by U. S. Public Health Service Research Grant HE-02965, and Training Grant TI HE-5273 and PO-AM 13430.

1973 • 272 citations

Role of plasma lecithin:cholesterol acyltransferase in the metabolism of high density lipoproteins

1966 • 272 citations

Lipoproteins in atherosclerosis

1951 • 271 citations

Isolation and characterization of polypeptides of human serum lipoproteins

1969 • 271 citations

Molecular complexes in the isolation and characterization of plasma lipoproteins

1961 • 267 citations

Separation of the main lipoprotein density classes from human plasma by rate-zonal ultracentrifugation

1974 • 265 citations

The Metabolic Basis of Inherited Disease

1967 • 263 citations

SERUM LIPID AND LIPOPROTEIN ALTERATIONS IN NEPHROSIS

1960 • 233 citations

The Ultracentrifugal Characterization and Isolation of Human Blood Lipids and Lipoproteins, with Applications to the Study of Atherosclerosis.

1951 • 230 citations

Studies on the composition and structure of plasma lipoproteins

1972 • 224 citations

Further Characterization of Apolipoproteins from the Human Plasma Very Low Density Lipoproteins

1970 • 215 citations

Preparation and Properties of Serum and Plasma Proteins. XXV. Composition and Properties of Human Serum β-Lipoprotein^1,2,3

1950 • 214 citations

Human serum lipoproteins. I. Chemical composition of four fractions.

1956 • 213 citations

EARLY EFFECTS OF FAT INGESTION ON LIPIDS AND LIPO-PROTEINS OF SERUM IN MAN

1957 • 203 citations

Isolation and partial characterization of apolipoprotein D: A new protein moiety of the human plasma lipoprotein system

1973 • 200 citations

The Complete Amino Acid Sequence of Alanine Apolipoprotein (apoC-III), an Apolipoprotein from Human Plasma Very Low Density Lipoproteins

1974 • 197 citations

Studies of the Composition and Structure of Serum Lipoproteins: Isolation, Purification, and Characterization of Very Low Density Lipoproteins of Human Serum^*

1965 • 188 citations

Assay of Total Plasma Apolipoprotein B Concentration in Human Subjects

1974 • 186 citations

Composition and structure of plasma lipoproteins. Isolation, composition, and immunochemical characterization of low density lipoprotein subfractions of human plasma

1970 • 173 citations

Calcium phosphate chromatography of normal human serum and of electrophoretically isolated serum proteins

1959 • 172 citations

Human Serum Lipoproteins and Their Interrelationships

1967 • 172 citations

LIPIDS AND POLYSACCHARIDES IN ELECTROPHORETICALLY SEPARATED BLOOD SERUM PROTEINS

1941 • 165 citations

“L.L.L.”

1948 • 152 citations

Apoliproproteins and lipoproteins

1971 • 145 citations

SITES OF INITIAL REMOVAL OF CHYLOMICRON TRIGLYCERIDE FATTY ACIDS FROM THE BLOOD*

1962 • 143 citations

The Size and Number of Polypeptide Chains in Human Serum Low Density Lipoprotein

1972 • 141 citations

A Rapid Method for the Bulk Isolation of β-Lipoproteins from Human Plasma¹

1957 • 139 citations

Radioimmunoassay of human high density lipoprotein apoprotein A-I

1975 • 138 citations

Factors affecting lipoprotein metabolism.

1965 • 137 citations

The analysis of human serum lipoprotein distributions.

1965 • 131 citations

Studies of the Composition and Structure of Serum Lipoproteins. Separation and Characterization of Phospholipid-Protein Residues Obtained by Partial Delipidization of Very Low Density Lipoproteins of Human Serum^*

1966 • 127 citations

Studies on Human Serum β1-Lipoprotein

1966 • 125 citations

Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins.

1975 • 125 citations

Electron microscopy of human serum lipoproteins using negative staining

1968 • 123 citations

The Characterization of a Discrete Series of Low Density Lipoproteins in the Disease, Hyper-pre-β-lipoproteinemia

1971 • 119 citations

Measurements of the molecular-weight variability of plasma low-density lipoproteins among normals and subjects with hyper-β-lipoproteinemia. Demonstration of macromolecular heterogeneity

1972 • 119 citations

Polypeptide Distribution of the Main Lipoprotein Density Classes Separated from Human Plasma by Rate Zonal Ultracentrifugation

1974 • 119 citations

Evidence for the identity of the major apoprotein in low density and very low density lipoproteins in normal subjects and patients with familial hyperlipoproteinemia

1972 • 116 citations

Chromatographic separation of serum lipoproteins on glass powder columns

1960 • 112 citations

Hyperlipoproteinemia

1954 • 108 citations

The Influence of Chemical and Physicochemical Nature of Macromolecular Polyanions on Their Interaction with Human Serum β-Lipoproteins

1960 • 107 citations

Studies of the composition and structure of plasma lipoproteins. C‐ and N‐terminal amino acids of the two nonidentical polypeptides of human plasma apolipoprotein A

1971 • 105 citations

The Intravenous Glucose Tolerance Test in Atherosclerotic Disease with Special Reference to Obesity, Hypertension, Diabetic Heredity and Cholesterol Values

1962 • 105 citations

Antigen Polymorphism of a Low-Density Beta-Lipoprotein. Allotypy in Human Serum

1962 • 103 citations

Flotation rates, molecular weights and hydrated densities of the low‐density lipoproteins

1969 • 102 citations

Hypertriglyceridaemia Secondary to Liver Disease

1974 • 102 citations

Physical and Chemical Composition Studies of the Lipoproteins of Fasting and Heparinized Human Sera

1955 • 100 citations

The Primary Structure of High Density Apolipoprotein-Glutamine-I

1974 • 99 citations

Factors Affecting Lipoprotein Metabolism1 1This work was supported by grants from the Public Health Service (HE 08727-01) and from the Chicago and Illinois Heart Associations.2 2Literature published after June 30, 1964, is not included in this survey.

1965 • 97 citations

Solubilization and Properties of the Apoproteins of the Very Low- and Low-Density Lipoproteins of Human Serum^*

1966 • 96 citations

Hormones and Atherosclerosis

1960 • 95 citations

Properties of human serum low density lipoproteins after modification by succinic anhydride

1968 • 91 citations

Isoelectric fractionation and characterization of polypeptides from human serum very low density lipoproteins

1971 • 90 citations

INTERACTION OF HUMAN SERUM β-LIPOGLOBULIN WITH POLYANIONS

1957 • 87 citations

The Molecular Properties of ApoA-I from Human High Density Lipoprotein

1974 • 86 citations

The Analysis of Human Serum Lipoprotein Distributions1 1This work was supported by Research Grants HE 01882-09 and HE 02029-09 from the National Heart Institute, Public Health Service, Bethesda, Maryland, and by the United States Atomic Energy Commission.

1965 • 84 citations

Physicochemical properties of low-density lipoproteins of normal human plasma. Evidence for the occurrence of lipoprotein B in associated and free forms

1974 • 84 citations

Experiments on the Degradation of Lipoproteins from Serum

1954 • 83 citations

N-Terminal Amino Acid and Lipid Composition of Lipoproteins from Chyle and Plasma

1958 • 83 citations

Study of the Mechanism of Hyperlipemia

1961 • 82 citations

ON THE GEOMETRICAL ARRANGEMENT OF THE PROTEIN SUBUNITS OF HUMAN SERUM LOW-DENSITY LIPOPROTEIN: EVIDENCE FOR A DODECAHEDRAL MODEL

1969 • 72 citations

Human serum lipoproteins. Evidence for three classes of lipoproteins in SfO-2

1972 • 71 citations

Differential activation of lipoprotein lipase from human post‐heparin plasma, milk and adipose tissue by polypeptides of human serum Apolipoprotein C

1971 • 69 citations

Composition and concentration of apolipoproteins in very-low-and low-density lipoproteins of normal human plasma.

1974 • 68 citations

Immunoassay of Plasma Low-Density Lipoproteins

1970 • 68 citations

Hydrodynamic studies of human low-density lipoproteins. Evaluation of the diffusion coefficient and the preferential hydration

1971 • 67 citations

THE ORIGIN, METABOLISM, AND STRUCTURE OF NORMAL HUMAN SERUM LIPOPROTEINS

1962 • 65 citations

N-terminal residues of serum lipoproteins

1956 • 65 citations

The synthesis of low- and high-density lipoproteins by rat liver in vitro

1958 • 64 citations

On the apoprotein composition of human plasma very low density lipoprotein subfractions

1972 • 62 citations

Some physical and chemical properties of the lipoproteins produced by lipolysis of human serum Sf 20–400 lipoproteins by post-heparin plasma

1962 • 61 citations

Lipoprotein of the Density 1. 006–1. 020 in the Plasma of Patients with Type III Hyperlipoproteinaemia in the Postabsorptive State

1975 • 60 citations

Separation and size determination of human serum lipoproteins by agarose gel filtration

1967 • 59 citations

LIPOPROTEIN PATTERNS IN MYOCARDIAL INFARCTION

1957 • 57 citations

Isolation and characterization of the cyanogen bromide fragments from the high-density apolipoprotein glutamine I

1973 • 56 citations

SUBUNIT HETEROGENEITY IN HUMAN SERUM BETA LIPOPROTEIN

1970 • 55 citations

The isolation of lipoproteins from human plasma by ultracentrifugation in zonal rotors

1971 • 53 citations

The carbohydrate constituents of human serum β-lipoprotein: Galactose, mannose, glucosamine and sialic acid

1962 • 52 citations

STUDIES ON THE ANTIGENICITY OF ß- AND α1-LIPOPROTEINS OF HUMAN SERUM

1958 • 52 citations

Demonstration of a protease‐like activity in human serum low density lipoprotein

1974 • 52 citations

On the Antigenic Identity of Human Serum Beta and Alpha-2 Lipoproteins, and Their Identification in the Aortic Intima

1961 • 51 citations

Correction of COOH-terminal Amino Acids of Human Plasma Very Low Density Apolipoproteins

1971 • 51 citations

A Screening Test forα₁-Antitrypsin Deficiency

1972 • 50 citations

Radioimmunoassay of human plasma apolipoproteins

1975 • 50 citations

STRUCTURE AND HOMOGENEITY OF THE LOW‐DENSITY SERUM LIPOPROTEINS

1959 • 50 citations

On a Low-density Lipoprotein Appearing in Normal Human Plasma.

1947 • 48 citations

The Molecular Weights and Dimensions of Some Human Serum Lipoproteins

1956 • 47 citations

Hydrodynamic analysis of human low density lipoproteins

1973 • 47 citations

POLYDISPERSITY OF HUMAN LOW‐DENSITY LIPOPROTEINS*

1969 • 47 citations

Contribution of carotenoids to the optical activity of human serum low-density lipoprotein

1974 • 46 citations

Immunological evidence for the presence of B protein (apoprotein of Β-lipoprotein) in normal and abetalipoproteinemic plasma

1967 • 45 citations

Amino acid composition of the proteins from chylomicrons and human serum lipoproteins

1967 • 45 citations

The Incorporation of Amino Acids into Soluble Lipoproteins by Cell-free Preparations from Rat Liver

1963 • 44 citations

THE ANTIGENIC SIMILARITY OF HUMAN LOW DENSITY LIPOPROTEINS

1955 • 43 citations

Identification of the protein moiety of an abnormal human plasma low‐density lipoprotein in obstructive jaundice

1969 • 43 citations

Subunit structure of the apoprotein of human serum low density lipoproteins

1974 • 42 citations

Purification of animal neurotoxins: Isolation and characterization of three neurotoxins from the venom of Naja nigricollis mossambica Peters

1974 • 41 citations

The protein moiety of human serum β-lipoproteins

1967 • 40 citations

STUDIES ON THE IMMUNOCHEMISTRY OF HUMAN LOW DENSITY LIPOPROTEINS UTILIZING AN HEMAGGLUTINATION TECHNIQUE

1959 • 39 citations

REVERSIBLE THERMAL CONFORMATION CHANGES IN HUMAN SERUM LOW-DENSITY LIPOPROTEIN

1969 • 39 citations

Improved Techniques for Assessment of Serum Lipoprotein Patterns. II. Rapid Method for Diagnosis of Type III Hyperlipoproteinemia without Ultracentrifugation

1973 • 38 citations

The structure and properties of human beta-lipoprotein and beta-apoprotein

1968 • 37 citations

OBSERVATIONS ON THE ABSORPTION OF CAROTENE AND VITAMIN A

1935 • 37 citations

Isolation of plasma lipoproteins by zonal ultracentrifugation in the B14 and B15 titanium rotors

1970 • 36 citations

Immunological characteristics of human low-density lipoproteins

1964 • 36 citations

Rapid molecular weight estimates for low-density lipoproteins

1969 • 35 citations

Determination of the molecular weight of apoprotein subunits from low density lipoprotein by gel filtration

1968 • 34 citations

Isolation and analysis of human plasma lipoproteins accumulating postprandial in an intermediate density fraction (d 1.006–1.019 g/ml)

1974 • 33 citations

Preparation and Properties of Serum and Plasma Proteins, XXXV

1960 • 33 citations

LIPIDS CARRIED BY Sf 0-12 LIPOPROTEIN IN NORMAL AND HYPERCHOLESTEROLÆMIC SERUM

1962 • 33 citations

Hormones and Atherosclerosis

1959 • 33 citations

A new precipitation method for estimating serum beta lipoproteins.

1959 • 32 citations

Effect of sodium dodecyl sulphate on human plasma low density lipoproteins

1970 • 32 citations

Proteolysis of Human Serum β-Lipoprotein

1964 • 31 citations

Flotation equilibrium of serum low density lipoproteins

1974 • 31 citations

Immunochemical Studies of Human Plasma Beta Lipoprotein

1955 • 31 citations

Immunochemical Studies of Human Serum Fractionated by Gel Filtration with Sephadex G-200

1964 • 30 citations

The Characterization and Occurrence of an S 20 Serum Lipoprotein

1970 • 26 citations

Fractionation of lipoproteins from blood by gel filtration

1966 • 26 citations

Fractionation of Human Plasma Macroglobulins by Gel Filtration on Pearl-Condensed Agar.

1964 • 26 citations

Protein components of human plasma high- and low-density lipoproteins

1968 • 25 citations

Studies of the composition and structure of plasma lipoproteins. C‐ and N‐terminal amino acids of C‐I polypeptide (“R‐Val”) of human plasma apolipoprotein C

1972 • 25 citations

Identification and Genetic Control of Two New Low-Density Lipoprotein Allotypes: Phenogroups at the Lpq Locus

1969 • 25 citations

The Immunochemical Heterogeneity of Human Plasma β-Lipoprotein

1953 • 24 citations

The distribution of β-lipoproteins in human plasma

1963 • 23 citations

Peptide composition of human plasma apolipoproteins A, B and C.

1972 • 20 citations

Gel filtration behaviour of human serum lipoproteins

1966 • 20 citations

The isolation of human serum lipoproteins by zonal ultracentrifugation

1968 • 20 citations

Immunochemical Heterogeneity of Human Plasma Lipoproteins

1957 • 19 citations

Heparin-calcium complexes as a measure of serum low-density lipoproteins

1966 • 17 citations

Isolation of human serum low‐density lipoproteins with the aid of an immune‐specific adsorber

1970 • 16 citations

Proteins of S_f 10-400 Lipoproteins from Lipemic Human Plasma^*

1965 • 15 citations

Fractionation of Plasma Lipoproteins with Preparative Zonal Ultracentrifugation

1969 • 15 citations

Studies on the B-Protein of Human Serum β-Lipoprotein Using SDS-Polyacrylamide Gel Electrophoresis

1973 • 14 citations

Modification of the Effects of Adrenal Cortical Steroids and Androgens on Serum Lipids and Lipoproteins by Caloric Supplementation and by Isocaloric Substitution of Carbohydrate for Dietary Protein

1959 • 13 citations

Disc electrophoresis of subclasses of human serum low density lipoproteins

1969 • 12 citations

Elimination of low‐density lipoprotein‐polyanion interaction by amino modifications

1970 • 11 citations

Heterogeneity of Human Serum Beta-lipoprotein

1962 • 11 citations

The isolation of low-density (β-)lipoprotein from small volumes of human serum

1967 • 9 citations

Cholesterol and phospholipid content of human β-lipoprotein in different lipemic states and following myocardial infarction

1961 • 9 citations

Glycoprotein Content of Serum Lipoproteins.

1959 • 9 citations

Lipid transport and lipoprotein interconversions

1961 • 7 citations

A modified preparative ultracentrifuge technique for separating human serum lipoproteins

1961 • 6 citations

Dissociation of low density lipoprotein-antibody precipitates at alkaline pH

1967 • 6 citations

Identification of apolipoproteins in lipoprotein density classes of hypercholesterolemia (type IIa)

1975 • 6 citations

Advances in Biological and Medical Physics, Vol. 8.

1963 • 6 citations

Protein fractionation IV. Characterization of serum lipoproteins by chromatography on deae-cellulose

1961 • 5 citations

Immunological studies of the protein moieties of human plasma very low‐density and low‐density lipoproteins

1974 • 4 citations

Low-density lipoprotein of human plasma: N-terminal amino acids in familial hyperbetalipoproteinemia (type II)

1971 • 4 citations

Heterogeneity of maleylated and partially delipidated low density lipoproteins from human plasma.

1969 • 3 citations

Electrofocusing of Normal Apolipoproteins and the Amino Acids of Their Subfractions

1972 • 1 citations

Deleted Work

1955 • 0 citations