Insulin-Sensitive Glucoregulator Chemoreceptors in the Central Nervous System: Their Putative Role in Glucose Homeostasis

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Hypothalamic lesions and adiposity in the rat

1940 • 965 citations

Hunger: Basic mechanisms and clinical implications

1976 • 915 citations

Neural control of the endocrine pancreas.

1974 • 630 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Identification of insulin in rat brain.

1978 • 599 citations

Studies of Insulin, Growth Hormone and Prolactin Binding: Tissue Distribution, Species Variation and Characterization

1974 • 592 citations

Glucose and Osmosensitive Neurones of the Rat Hypothalamus

1969 • 588 citations

Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro

1964 • 540 citations

POSSIBLE DUAL ROLE FOR VASOACTIVE INTESTINAL PEPTIDE AS GASTROINTESTINAL HORMONE AND NEUROTRANSMITTER SUBSTANCE

1976 • 496 citations

Insulin Receptors in the Liver: Specific Binding of [ ¹²⁵ I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

1971 • 494 citations

Transport of glucose from blood to brain.

1979 • 477 citations

Effects of carbohydrates on secretion of insulin from isolated rat pancreas

1963 • 432 citations

Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.

1976 • 415 citations

Isolation of the Insulin Receptor of Liver and Fat-Cell Membranes

1972 • 397 citations

Activity of single neurons in the hypothalamic feeding centers: effect of glucose

1964 • 386 citations

INTERACTION OF INSULIN WITH THE CELL MEMBRANE: THE PRIMARY ACTION OF INSULIN

1969 • 381 citations

Quantitative Aspects of the Insulin-Receptor Interaction in Liver Plasma Membranes

1974 • 378 citations

Studies on Rat Adipose Tissue in Vitro

1958 • 371 citations

The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man.

1976 • 350 citations

Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels

1979 • 324 citations

Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat.

1962 • 324 citations

Insulin-Binding Sites in the Rat Brain: In Vivo Localization to the Circumventricular Organs by Quantitative Radioautography*

1979 • 319 citations

Perifusion of Isolated Rat Islets in Vitro: Participation of the Microtubular System in the Biphasic Release of Insulin

1972 • 311 citations

Frontiers in Neuroendocrinology, 1973.

1973 • 302 citations

Growth Hormone and Insulin Levels in Weanling Rats with Ventromedial Hypothalamic Lesions

1968 • 294 citations

Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels

1971 • 291 citations

Plasma glucose, non-esterified fatty acid and insulin concentrations in hypothalamic-hyperphagic rats

1964 • 285 citations

Insulin in the Cerebrospinal Fluid

1967 • 283 citations

Influence of Endogenous Insulin Secretion on Splanchnic Glucose and Amino Acid Metabolism in Man

1971 • 270 citations

Blood glucose and the liver

1959 • 259 citations

Cholecystokinin and its COOH-terminal octapeptide in the pig brain.

1977 • 254 citations

Reciprocal Influences of the Ventromedial and Lateral Hypothalamic Nuclei on Blood Glucose Level and Liver Glycogen Content

1966 • 236 citations

Gluconeogenesis in the perfused liver

1966 • 200 citations

Insulin acting as a modulator of feeding through the hypothalamus

1981 • 188 citations

Insulin Binding Sites Localized to Nerve Terminals in Rat Median Eminence and Arcuate Nucleus

1980 • 187 citations

Regulation of glycogen metabolism in liver by the autonomic nervous system II. Neural control of glycogenolytic enzymes

1968 • 178 citations

Insulin binds to brain blood vessels in vivo

1979 • 177 citations

Metabolic Mapping of Functional Activity in Human Subjects with the [ ¹⁸ F]Fluorodeoxyglucose Technique

1981 • 173 citations

BINDING OF HORMONE TO TISSUE: THE FIRST STEP IN POLYPEPTIDE HORMONE ACTION

1966 • 168 citations

A direct action of insulin on the hypothalamic satiety center

1970 • 153 citations

Effect of Glucagon: Insulin Ratios on Hepatic Metabolism

1974 • 153 citations

Neural Regulation of Insulin Secretion in the Dog

1973 • 150 citations

Decreased Insulin Binding to Lymphocytes from Diabetic Subjects

1974 • 144 citations

Effect of insulin on release of glucose and urea by isolated rat liver

1963 • 143 citations

Glycogen Synthetase Activity in Liver: Regulation by the Autonomic Nerves

1967 • 143 citations

Insulin is ubiquitous in extrapancreatic tissues of rats and humans.

1980 • 140 citations

Carbohydrate Homeostasis

1970 • 120 citations

Stimulation of Counterregulatory Hormonal Responses in Diabetic Man by a Fall in Glucose Concentration

1980 • 120 citations

Antagonism Between the Effects of Insulin and Glucagon on the Isolated Liver

1969 • 118 citations

Characterization of the Glucagon Response to Hypoglycemia in Man

1974 • 115 citations

Two Binding Sites for Estradiol in Rat Uterine Nuclei: Relationship to Uterotropic Response*

1979 • 106 citations

The Effect of Adrenergic Blockade on the Glucagon Responses to Starvation and Hypoglycemia in Man

1974 • 105 citations

Destruction of Insulin Effector System of Adipose Tissue Cells by Proteolytic Enzymes

1969 • 102 citations

The effect of 2‐deoxy‐D‐glucose and D‐glucose on the efferent discharge rate of sympathetic nerves.

1975 • 99 citations

THE CARBOHYDRATE METABOLISM OF BRAIN

1936 • 95 citations

Influence of glucagon and 3', 5'-AMP on insulin responsiveness of the perfused rat liver

1968 • 94 citations

ACID-BASE STATUS AND PARATHYROID HORMONE IN DIALYSED PATIENTS

1976 • 94 citations

Glucoreceptor Mechanisms in Islets of Langerhans

1972 • 91 citations

Evidence for an insulin-sensitive receptor in the central nervous system

1972 • 85 citations

The Failure of Rat Hypothalamic Tissues to Take up Labeled Insulin in Vivo or to Respond to Insulin in Vitro

1977 • 83 citations

Cellular basis of direct insulin action in the central nervous system

1981 • 79 citations

Neural Control of Counter-Regulatory Events during Glucopenia in Man

1973 • 79 citations

Role of Beta-Adrenergic Receptors in Counterregulation to Insulin-induced Hypoglycemia

1968 • 77 citations

Animal Responses to 2-Deoxy-D-Glucose Administration

1958 • 73 citations

Effect of infusion of insulin into portal vein on hepatic extraction of insulin in anesthetized dogs

1975 • 73 citations

Short-term influence of intra-ventromedial hypothalamic administration of insulin on feeding in normal and diabetic rats

1974 • 66 citations

THE PHYSIOLOGIC SIGNIFICANCE OF THE SECRETION OF ENDOGENOUS INSULIN INTO THE PORTAL CIRCULATION. I. COMPARISON OF THE EFFECTS OF GLUCAGON-FREE INSULIN ADMINISTERED VIA THE PORTAL VEIN AND VIA A PERIPHERAL VEIN ON THE MAGNITUDE OF HYPOGLYCEMIA AND PERIPHERAL GLUCOSE UTILIZATION1

1958 • 65 citations

Insulin Recoverable from Tissues

1980 • 61 citations

Localization of CNS glucoregulatory insulin receptors within the ventromedial hypothalamus

1975 • 61 citations

Comparison of Peripheral and Portal Routes of Insulin Infusion by a Computer-controlled Insulin Infusion System (Artificial Endocrine Pancreas)

1976 • 59 citations

Plasma Immunoreactive Corticotrophin and Cortisol Response to Insulin Hypoglycemia in Normal Subjects and Patients with Pituitary Disease

1971 • 57 citations

Plasma insulin responses to glucose in femoral, hepatic, and pancreatic veins in dogs

1966 • 55 citations

STUDIES ON THE CONDITIONS OF ACTIVITY IN ENDOCRINE GLANDS

1925 • 54 citations

Influence of the insulin sensitive central nervous system glucoregulator receptor on hepatic glucose metabolism.

1975 • 51 citations

Studies on the Nature and Mode of Action of the Insulin-sensitive Glucoregulator Receptor in the Central Nervous System

1975 • 51 citations

Effects of insulin on liver glycogen synthesis and breakdown in the dog

1965 • 51 citations

ACTION OF INSULIN ON GLUCOSE UPTAKE OF RAT BRAIN SLICES AND ISOLATED RAT CEREBELLUM

1961 • 49 citations

Characterization of Insulin Stimulation of the Incorporation of Radioactive Precursors into Macromolecules in Cultured Rat Brain Cells*

1980 • 48 citations

CEREBRAL BLOOD FLOW AND BRAIN METABOLISM DURING INSULIN HYPOGLYCEMIA

1941 • 47 citations

Studies on the Perfused Rat Liver: I. Effects of Glucagon and Insulin on Glucose Metabolism

1966 • 46 citations

CARBOHYDRATE METABOLISM

1947 • 46 citations

Factors modifying plasma insulin and glucose responses to ventromedial hypothalamic stimulation

1974 • 45 citations

Effects of insulin on net carbohydrate alterations in perfused rat liver

1967 • 42 citations

Dynamics of glucose autoregulation in the isolated, blood-perfused canine liver

1974 • 42 citations

THE MODE OF INACTIVATION OF INSULIN BY RAT LIVER EXTRACTS

1955 • 42 citations

Streamline flow in the human portal vein.

1973 • 41 citations

Effects of insulin on glucose metabolism by the perfused normal rat liver

1967 • 40 citations

Cerebral localization of insulin by immunofluorescence

1978 • 39 citations

Effect on blood glucose concentration of changes in availability of glucose to the brain

1963 • 34 citations

The stimulus-secretion coupling of glucose-induced insulin release XII. Effects of diazoxide and gliclazide upon45calcium efflux from perifused islets

1973 • 33 citations

Cerebral functional effects of 2-deoxy-D-glucose and 3-O-methylglucose in rhesus monkeys

1973 • 32 citations

Drug control of hyperglycemia and inhibition of insulin secretion due to centrally administered 2-deoxy-D-glucose

1973 • 32 citations

Relationship Between Sugar Concentration and Glycogenetic Action of Insulin on Rat Diaphragm in vitro

1941 • 32 citations

Influence of the age of erythrocytes on their insulin receptors

1980 • 32 citations

Images of Jupiter's Sulfur Ring

1980 • 31 citations

A method of direct chemical brain stimulation in behavioral studies using microiontophoresis

1975 • 29 citations

A study of gluconeogenesis by the administration of 2-deoxyglucose. I

1966 • 27 citations

Insulin: Rates and Routes of Delivery

1974 • 26 citations

Studies on a direct effect of insulin on the central nervous system: a review.

1961 • 25 citations

Studies With an Artificial Endocrine Pancreas

1977 • 23 citations

Neuropharmacological characterization of insulin-sensitive CNS glucoregulator

1975 • 22 citations

Studies on the nature and mode of action of the insulin-sensitive glucoregulator receptor in the central nervous system

1975 • 22 citations

Comparison of peripheral and portal routes of insulin infusion by a computer-controlled insulin infusion system (artificial endocrine pancreas)

1976 • 21 citations

Glucose Metabolism in Brains of Diabetic Rats

1969 • 20 citations

Insulin Sensitivity of Isolated Perfused Rat Liver

1975 • 15 citations

COMPARISON OF THE EFFECT OF INTRAPORTAL AND INTRAVENOUS INFUSION OF INSULIN ON BLOOD GLUCOSE AND FREE FATTY ACIDS IN PERIPHERAL VENOUS BLOOD OF MAN

1974 • 15 citations

The physiologic significance of portal vs. peripheral injection of insulin in man

1975 • 12 citations

Insulin Action upon Insulin-Insensitive Tissue Following Impaired Degradation of the Hormone.

1967 • 11 citations

STUDIES ON CARBOHYDRATE METABOLISM FOLLOWING DENERVATION OF THE LIVER

1931 • 10 citations

Insulin Control of Hepatic Glucose Production

1975 • 8 citations

Effect of cephalic glucose infusion on insulin secretion

1975 • 7 citations

Insulin sensitivity of isolated perfused rat liver

1975 • 7 citations

The Effect of Hypophysectomy on the Function of the Insulin-Sensitive Central Nervous System Glucoregulator Receptor

1975 • 4 citations

A neurohumoral link in the initial hyperglycemic response to food ingestion.

1974 • 2 citations