Inhibitors of Fatty Acid Oxidation and the Pathway of Fatty Acid Biosynthesis from Glucose

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver

1953 • 1,318 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

The Regulation of Glycolysis and Gluconeogenesis in Animal Tissues

1968 • 635 citations

ENZYMATIC SYNTHESIS OF THE COENZYME A DERIVATIVES OF LONG CHAIN FATTY ACIDS

1953 • 631 citations

Biochemistry: The Molecular Basis of Cell Structure and Function

1970 • 606 citations

Long-chain carnitine acyltransferase and the role of acylcarnitine derivatives in the catalytic increase of fatty acid oxidation induced by carnitine

1963 • 525 citations

Phosphofructokinase and the Pasteur effect

1962 • 517 citations

Factors Influencing the Rates of Long-Chain Fatty Acid Oxidation and Synthesis in Mammalian Systems

1961 • 479 citations

Crystallization, Characterization and Metabolic Regulation of Two Types of Pyruvate Kinase Isolated from Rat Tissues*

1967 • 456 citations

SYSTEMS USED FOR THE TRANSPORT OF SUBSTRATES INTO MITOCHONDRIA

1968 • 449 citations

Studies on Heart Phosphofructokinase: Purification, Inhibition, and Activation

1963 • 447 citations

Carnitine and Its Role in Fatty Acid Metabolism* *Work reviewed from this laboratory was supported by grants A-1465 and A-1682 from the National Institutes of Health.

1963 • 446 citations

Metabolism of Glycerolipids

1965 • 436 citations

PHOSPHORYLATION COUPLED TO OXIDATION OF DIHYDRODIPHOSPHOPYRIDINE NUCLEOTIDE

1951 • 423 citations

The Effect of Nicotinic Acid on the Plasma Free Fatty Acids Demonstration of a Metabolic Type of Sympathicolysis

1962 • 410 citations

Studies on Rat Adipose Tissue in Vitro

1958 • 371 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

STUDIES ON FATTY ACID OXIDATION

1953 • 354 citations

Adenyl Cyclase in Fat Cells

1969 • 352 citations

An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase

1970 • 346 citations

Variations in tissue contents of coenzyme A thio esters and possible metabolic implications

1964 • 343 citations

Kinetic Evidence for Multiple Binding Sites on Phosphofructokinase

1966 • 336 citations

The role of biotin-dependent carboxylations in biosynthetic reactions

1967 • 283 citations

Intestinal absorption of fats

1964 • 282 citations

Glucose Penetration Into Liver

1958 • 280 citations

The metabolism of adipose tissue in vitro

1961 • 274 citations

The Effect of Palmityl Coenzyme A on Glucose 6-Phosphate Dehydrogenase and Other Enzymes

1966 • 272 citations

Tricarballylate and hydroxycitrate: Substrate and inhibitor of ATP: Citrate oxaloacetate lyase

1969 • 259 citations

Organ and subcellular distribution of fatty acid activating enzymes in the rat

1971 • 258 citations

The regulation of the release of ketone bodies by the liver

1966 • 254 citations

Effects of prostaglandin E opposing those of catecholamines on blood pressure and on triglyceride breakdown in adipose tissue

1963 • 237 citations

Citrate and the Conversion of Carbohydrate into Fat

1970 • 236 citations

Paths of Carbon in Gluconeogenesis and Lipogenesis

1966 • 229 citations

Properties of Partially Purified Carnitine Acetyltransferase

1963 • 220 citations

Adipose Tissue. Regulation and Metabolic Functions.

1971 • 217 citations

Activation of Adipose Tissue Lipase by Skeletal Muscle Cyclic Adenosine 3',5'-Monophosphate-stimulated Protein Kinase

1970 • 216 citations

The Role of Cyclic AMP in the Control of Carbohydrate Metabolism

1969 • 210 citations

BIOSYNTHESIS OF FATTY ACIDS BY CELL-FREE OR WATER-SOLUBLE ENZYME SYSTEMS

1952 • 207 citations

Palmityl-coa:carnitine palmityltransferase

1964 • 204 citations

Long Chain Fatty Acid Activation in Subcellular Preparations from Rat Liver

1968 • 200 citations

Inhibition of citrate-synthase by palmityl-coenzyme A

1963 • 199 citations

The inhibition of malate, tricarboxylate and oxoglutarate entry into mitochondria by 2-n-butylmalonate

1967 • 181 citations

The purification and properties of microsomal palmitoyl-coenzyme A synthetase

1971 • 180 citations

THE EFFECT OF INSULIN AND PITUITARY HORMONES ON GLUCOSE UPTAKE IN MUSCLE

1951 • 170 citations

Effect of Nucleic Acid Metabolites on Lipolysis in Adipose Tissue

1961 • 169 citations

The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate

1967 • 165 citations

The role of acylcarnitine esters and carnitine palmityltransferase in the transport of fatty acyl groups across mitochondrial membranes.

1965 • 162 citations

The transport of pyruvate in rat liver mitochondria

1971 • 161 citations

The synthesis of neutral glycerides by fractions of rat liver homogenates

1957 • 157 citations

Hypoglycin and hypoglycin-like compounds.

1969 • 153 citations

Inhibition of Fatty Acid Stimulation of Gluconeogenesis by (+)-Decanoylcarnitine in Perfused Rat Liver

1968 • 152 citations

Gluconeogenesis in the kidney cortex. Effects of <scp>d</scp>-malate and amino-oxyacetate

1970 • 151 citations

Regulation of fatty acid synthesis at the acetyl-CoA carboxylation step

1965 • 142 citations

Palmityl-coenzyme a inhibition of the citrate-condensing enzyme

1965 • 137 citations

Molecular characteristics of liver acetyl CoA carboxylase.

1966 • 134 citations

Conversion of carbohydrate to fat in adipose tissue: an energy-yielding and, therefore, self-limiting process

1970 • 131 citations

Carnitine Acetyltransferase

1965 • 129 citations

Long-chain acyl-CoA synthetase in rat liver. A new assay procedure for the enzyme, and studies on its intracellular localization

1967 • 124 citations

Insulin-like Actions of Ribonucleic Acid, Adenylic Acid, and Adenosine

1962 • 124 citations

Citrate cleavage in adipose tissue.

1965 • 123 citations

Regulation of rat liver pyruvate kinase. The effect of preincubation, pH, copper ions, fructose 1,6-diphosphate and dietary changes on enzyme activity

1968 • 107 citations

Brain disorders induced by pharmacological blockade of the pentose phosphate pathway

1969 • 106 citations

Mode of Inhibition of β-Hydroxydecanoyl Thioester Dehydrase by 3-Decynoyl-N-acetylcysteamine

1970 • 99 citations

Inhibition of citrate synthase by succinyl‐CoA and other metabolites

1971 • 99 citations

Adipose-tissue pyruvate kinase. Properties and interconversion of two active forms

1968 • 96 citations

Conditions for the self-catalysed inactivation of carnitine acetyltransferase. A novel form of enzyme inhibition

1969 • 96 citations

The localization of some coenzyme A-dependant enzymes in rat liver mitochondria

1970 • 94 citations

Protein kinase activation and phosphorylation of a purified hormone-sensitive lipase

1970 • 94 citations

ATP‐dependent inactivation of heart muscle pyruvate dehydrogenase and reactivation by Mg⁺⁺

1969 • 93 citations

THE EFFECT OF INSULIN AND PITUITARY HORMONES ON GLUCOSE UPTAKE IN MUSCLE

1951 • 92 citations

The Sensitivity of Exchange Reactions of Tricarboxylate, 2‐Oxoglutarate and Dicarboxylate Transporting Systems of Rat Liver Mitochondria to Inhibition by 2‐Pentylmalonate, p‐Iodobenzylmalonate, and Benzene 1,2,3‐tricarboxylate

1971 • 92 citations

Interrelations between fatty acid oxidation and the control of gluconeogenesis in perfused rat liver

1968 • 90 citations

LIVER ACETYL COA CARBOXYLASE: THE DISSOCIATION-REASSOCIATION PROCESS AND ITS RELATION TO CATALYTIC ACTIVITY

1966 • 89 citations

Regulation of Gluconeogenesis by Fatty Acid Oxidation in Isolated Perfused Livers of Non-Starved Rats

1968 • 89 citations

The substrate specificity of carnitine acetyltransferase

1967 • 87 citations

Factors Affecting the Kinetics and Equilibrium of Exchange Reactions of the Citrate-transporting System of Rat Liver Mitochondria

1971 • 86 citations

A CONSTITUENT OF RAW EGG WHITE CAPABLE OF INACTIVATING BIOTIN IN VITRO

1940 • 86 citations

The inhibition of citrate synthase by adenosine triphosphate

1968 • 86 citations

Coupling mechanisms in anionic substrate transport across the inner membrane of rat-liver mitochondria

1970 • 84 citations

Carnitine palmitoyltransferase activities (EC 2.3.1.–) of rat liver mitochondria

1970 • 84 citations

Effect of Insulin on Fatty Acid Synthesis from Pyuvate, Lactate, or Endogenous Sources in Adipose Tissue: Evidence for the Hormonal Regulation of Pyruvate Dehydrogenase¹

1970 • 82 citations

The separation and properties of two forms of carnitine palmitoyltransferase from ox liver mitochondria

1971 • 82 citations

Effect of Methylmalonyl Coenzyme A, a Metabolite Which Accumulates in Vitamin B12 Deficiency, on Fatty Acid Synthesis

1970 • 81 citations

The catabolism of long chain fatty acids in mammalian tissues.

1968 • 81 citations

ATP controlled acetoacetate and citrate synthesis by rat liver mitochondria oxidising palmitoyl-carnitine, and the inhibition of citrate synthase by ATP

1966 • 81 citations

Metabolic effects of hypoglycin and methylenecyclopropaneacetic acid

1966 • 81 citations

Net Synthesis of Lecithin in an Isolated Enzyme System

1956 • 77 citations

Regulation of Fatty Acid Biosynthesis* *The unpublished experimental work from this laboratory presented here and the preparation of this article have been assisted by grants from the National Institutes of Health (R01-HE-10406) and the National Science Foundation (GB-5142X).

1971 • 76 citations

Effect of Divalent Metal Ions on Nucleotide Inhibition of Pig Heart Citrate Synthase

1966 • 75 citations

An Hypothesis Concerning the Role of Carnitine in the Control of Interrelations between Fatty Acid and Carbohydrate Metabolism

1967 • 74 citations

Lipogenesis in the pigeon: in vitro studies

1966 • 74 citations

Inhibition of citrate formation by long-chain acyl thioesters of coenzyme A as a possible control mechanism in fatty acid bioxynthesis

1963 • 73 citations

The Effects of 2‐Ethylcitrate and Tricarballylate on Citrate Transport in Rat Liver Mitochondria and Fatty Acid Synthesis in Rat White Adipose Tissue

1970 • 72 citations

Insulin activates Pyruvate Dehydrogenase in Rat Epididymal Adipose Tissue

1971 • 70 citations

On the Mechanism of Dehydrogenation of Fatty Acyl Derivatives of Coenzyme A. IV. Kinetic Studies

1956 • 70 citations

Control Factors Affecting Gluconeogenesis in Perfused Rat Liver

1970 • 69 citations

Hormonal control of enzymes participating in gluconeogenesis and lipogenesis

1965 • 69 citations

Purification and Properties of Acetyl Coenzyme A Synthetase from Bovine Heart Mitochondria

1963 • 68 citations

Kinetics of succinate uptake by rat‐liver mitochondria

1969 • 66 citations

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Fatty acid oxidation

1968 • 65 citations

The Role of Endogenous Lipid in Gluconeogenesis and Ketogenesis of Perfused Rat Liver

1969 • 65 citations

Diisopropylammonium dichloroacetate (DIPA) and sodium dichloroacetate (DCA): Effect on glucose and fat metabolism in normal and diabetic tissue

1970 • 65 citations

Fatty acid biosynthesis and the role of the acyl carrier protein.

1967 • 65 citations

A Guanosine Triphosphate-dependent Acyl Coenzyme A Synthetase from Rat Liver Mitochondria

1967 • 64 citations

Hypoglycin A: A Specific Inhibitor of Isovaleryl CoA Dehydrogenase

1971 • 64 citations

Stimulation of Biosynthesis of Glyceride

1967 • 62 citations

Pyruvate Dehydrogenase Complex

1969 • 59 citations

HYPOGLYCIN AND RELATED HYPOGLYCAEMIC COMPOUNDS

1969 • 58 citations

Studies of the mechanism of the hypoglycemic action of 4-pentenoic acid.

1967 • 57 citations

Studies on the Mechanism of Fatty Acid Synthesis

1968 • 57 citations

Spectrophotometric studies of acyl-coenzyme A synthetases of rat liver mitochondria

1970 • 54 citations

Hypoglycaemic action of DIISOpropylammonium salts in experimental diabetes

1962 • 52 citations

The Effects of Detergents on Palmityl Coenzyme A:Carnitine Palmityltransferase

1967 • 51 citations

Transport of reduced nicotinamide–adenine dinucleotide into mitochondria of rat white adipose tissue

1970 • 51 citations

Citrate and the conversion of carbohydrate into fat. The regulation of fatty acid synthesis by rat liver extracts

1967 • 50 citations

Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria

1970 • 49 citations

Fatty Acid Biosynthesis and the Role of the Acyl Carrier Protein1 1This investigation was supported in part by grants from the United States Public Health Service, AM-10550, HE-10406, the National Science Foundation, GB-5056X, GB-5142X, and the American Cancer Society PRA-33.

1967 • 49 citations

Specific alkylation of a histidine residue in carnitine acetyltransferase by bromoacetyl-<scp>l</scp>-carnitine

1970 • 49 citations

7α‐dehydroxylation of cholic acid by Clostridium bifermentans strain ATCC 9714 and Clostridium sordellii strain NCIB 6929

1970 • 48 citations

The synthesis of higher glycerides via the monoglyceride pathway in hamster adipose tissue

1971 • 47 citations

Flavoproteins of mitochondrial fatty acid oxidation.

1967 • 47 citations

Carnitine octanoyltransferase. Evidence for a new enzyme in mitochondria

1971 • 46 citations

Regulation of fatty acid synthesis in adipose tissue

1966 • 46 citations

Interrelations between hepatic fatty acid oxidation and gluconeogenesis: a possible regulatory role of carnitine palmityltransferase.

1967 • 45 citations

Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Oxidative phosphorylation and mitochondrial oxidation of pyruvate, 3-hydroxybutyrate and tricarboxylic acid-cycle intermediates

1968 • 45 citations

MEMBRANES AND FATTY ACID METABOLISM

1968 • 45 citations

Acid-Base Changes in Brain and Blood of Rats Exposed to High Concentrations of Carbon Dioxide

1957 • 42 citations

The physiology and pharmacology of adipose tissue lipolysis: Its inhibition and implications for the treatment of diabetes

1967 • 40 citations

Inhibition of the Stearyl Coenzyme A Desaturase System by Sterculate

1970 • 40 citations

The mechanism of intestinal utilization of monoglycerides

1964 • 38 citations

The role of the cytoplasmic redox potential in the control of fatty acid synthesis from glucose, pyruvate and lactate in white adipose tissue

1970 • 38 citations

The effect of 4-pentenoic acid on fatty acid oxidation

1969 • 37 citations

Palmityl-CoA:carnitine palmityltransferase studies on the substrate specificity of the enzyme

1965 • 36 citations

Studies on the Control of Fatty Acid Synthesis

1967 • 35 citations

Intracellular distribution of palmitoyl-CoA synthetase in rat liver

1970 • 35 citations

Stimulation of fatty acid biosynthesis by phosphorylated sugars.

1966 • 34 citations

Effect of Phenazine Methosulfate on Lipogenesis

1970 • 34 citations

Mode of action of lipid-lowering agents. II. In vitro inhibition of acetyl coenzyme A carboxylase by a hypolipidemic drug

1970 • 33 citations

Inhibition of yeast pyruvate carboxylase by L-aspartate and oxaloacetate

1966 • 31 citations

Studies on medium-chain fatty acyl-coenzyme A synthetase. Purification and properties

1968 • 29 citations

Recent Developments in the Mechanism of Fat Absorption

1963 • 29 citations

An additional role for insulin in the control of fatty acid synthesis independent of glucose transport

1970 • 28 citations

Antitrachoma Activity of Rifamycin B and 8-O-Acetylrifamycin S

1971 • 26 citations

Inhibitors of the dicarboxylate and tricarboxylate transporting systems of rat liver mitochondria

1972 • 25 citations

A palmityl-CoA synthetase stimulating factor of particle free supernatants

1967 • 25 citations

Inhibition of pyruvate kinase and glucokinase by acetyl CoA and inhibition of glucokinase by phosphoenolpyruvate

1967 • 25 citations

Glucagon and the Permissive Action of Fatty Acids in Hepatic Gluconeogenesis

1971 • 24 citations

The action of atractyloside and AMP on long‐chain fatty acid oxidation and on the ATP‐dependent fatty acid thiokinase

1969 • 22 citations

On the mode of action of lipid-lowering agents. 3. Kinetics of activation and inhibition of acetyl coenzyme A carboxylase.

1970 • 20 citations

Relief of palmityl CoA inhibition of citrate synthase by long-chain acylcarnitine derivatives

1966 • 19 citations

On the Mode of Action of Lipid-lowering Agents

1970 • 18 citations

The inhibition of 2‐oxoglutarate entry into rat liver mitochondria by L‐aspartate

1969 • 17 citations

The effect of mitochondrial oxidations of inhibitors of the dicarboxylate anion transporting system

1969 • 16 citations

Die Hemmung der Ketogenese in Lebergewebe durch Tolbutamid und Glykodiazin in vitro

1969 • 14 citations

The inhibition of the biosynthesis of long-chain fatty acids by salicylate and nicotinate

1967 • 14 citations

Inhibition of hepatic gluconeogenesis and fatty acid oxidation by pent-4-enoic acid

1970 • 14 citations

Role of mitochondria in metabolism of pyruvate and lactate by rat adipose tissue

1971 • 13 citations

Hemmung der Lipolyse im Fettgewebe durch Methylisoxazolcarbons�uren

1968 • 11 citations

Effects of an acylcarnitine analogue, 2-bromomyristoylthiocarnitine, on mitochondrial respiration

1970 • 11 citations

THE MECHANISM OF FATTY ACID BIOSYNTHESIS AND THE INVOLVEMENT OF AN ACYL CARRIER PROTEIN

1965 • 11 citations

Effects in vitro and in vivo of synthetic phosphatidate phosphatase inhibitors

1968 • 8 citations

Fatty Acid Synthesis from Pyruvate in White Adipose Tissue: the Effect of Norepinephrine

1971 • 7 citations

Effect of Antilipolytic Compounds on Cyclic 3′, 5′-Adenosine Monophosphate Activation of Adipose Tissue Lipolysis

1971 • 6 citations

Chain-length specificity of inhibition of fatty acid oxidation by pent-4-enoly-L-carnitine and by pent-4-enoic acid

1970 • 2 citations