Regulatory acceptance of in vitro permeability studies in the context of the biopharmaceutics classification system

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

1999 • 895 citations

Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards

2000 • 724 citations

Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport

2000 • 434 citations

A Human Colonic Cell Line Sharing Similarities With Enterocytes as a Model to Examine Oral Absorption: Advantages and Limitations of the Caco-2 Model

1997 • 433 citations

The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications

1995 • 404 citations

The Influence of Culture Time and Passage Number on the Morphological and Physiological Development of Caco-2 Cells

1997 • 295 citations

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

2000 • 288 citations

Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond.

1997 • 279 citations

Gastrointestinal absorption of drugs: methods and studies

1999 • 277 citations

The use of cultured epithelial and endothelial cells for drug transport and metabolism studies.

1990 • 272 citations

Comparison between active and passive drug transport in human intestinal epithelial (caco-2) cells in vitro and human jejunum in vivo

1996 • 259 citations

Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line.

1998 • 239 citations

In vitro systems for studying intestinal drug absorption

1995 • 178 citations

Effect of molecular charge on intestinal epithelial drug transport: pH-dependent transport of cationic drugs.

1999 • 172 citations

The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development

1996 • 138 citations

Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers.

1996 • 119 citations

Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake.

1999 • 117 citations

Carrier-mediated transport and efflux mechanisms in Caco-2 cells

1996 • 98 citations

Comparison of HT29-18-C1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption.

1996 • 86 citations

Epithelial cells in culture as a model for the intestinal transport of antimicrobial agents

1992 • 86 citations

A conditionally immortalized epithelial cell line for studies of intestinal drug transport.

1999 • 84 citations

Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

1996 • 78 citations

Selection of development candidates based on in vitro permeability measurements

1997 • 52 citations

Cell culture techniques for the study of drug transport

1990 • 50 citations

Differentiated intestinal epithelial cell lines asin vitro models for predicting the intestinal absorption of drugs

1994 • 40 citations

Polarized efflux of 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers

1992 • 34 citations

Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression

2000 • 31 citations

The Biopharmaceutics Classification System: Highlights of the FDA's Draft Guidance

1999 • 16 citations

Rational Delivery Strategies for the Design of Peptides with Enhanced Oral Delivery

1994 • 8 citations

Validation of a Caco-2 cell monolayer culture for drug transport studies.

1998 • 8 citations