DRUGS AND MICROSOMAL ENZYME FORMATION IN VIVO AND IN MAMMALIAN CELL CULTURE

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Resolution of Multiple Ribonucleic Acid Species by Polyacrylamide Gel Electrophoresis^*

1967 • 866 citations

Effect of Actinomycin D on Cellular Nucleic Acid Synthesis and Virus Production

1961 • 602 citations

INHIBITION BY PUROMYCIN OF AMINO ACID INCORPORATION INTO PROTEIN

1959 • 561 citations

PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES

1965 • 531 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

Turnover of Constituents of the Endoplasmic Reticulum Membranes of Rat Hepatocytes

1967 • 484 citations

Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

1966 • 484 citations

Substrate-Induced Synthesis And Other Properties Of Benzpyrene Hydroxylase In Rat Liver

1957 • 475 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

1963 • 413 citations

Ribonucleic acid synthesis during the early action of thyroid hormones

1966 • 400 citations

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

1956 • 393 citations

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

1966 • 357 citations

Influence of turnover rates on the responses of enzymes to cortisone.

1965 • 348 citations

CHARACTERISTICS AND STABILIZATION OF DNAASE-SENSITIVE PROTEIN SYNTHESIS IN E. COLI EXTRACTS

1961 • 343 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

Turnover of Rat Liver Tyrosine Transaminase: Stabilization after Inhibition of Protein Synthesis

1967 • 287 citations

Relation of Cortisone and Synthesis of Ribonucleic Acid to Induced and Developmental Enzyme Formation

1963 • 280 citations

A PARADOXICAL EFFECT OF ACTINOMYCIN D: THE MECHANISM OF REGULATION OF ENZYME SYNTHESIS BY HYDROCORTISONE

1964 • 249 citations

MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYL-CHOLANTHRENE IN RATS.

1965 • 210 citations

Early Estrogen Effects on the Activity of Uterine Ribonucleic Acid Polymerase

1964 • 207 citations

The Role of Adenosine Triphosphate Deficiency in Ethionine-induced Inhibition of Protein Synthesis

1963 • 204 citations

Puromycin Inhibition of Enzyme Induction by 3-Methylcholanthrene and Phenobarbital

1963 • 179 citations

THE STIMULATORY EFFECT OF 3-METHYLCHOLANTHRENE ON BENZPYRENE HYDROXYLASE ACTIVITY IN SEVERAL RAT TISSUES: INHIBITION BY ACTINOMYCIN D AND PUROMYCIN.

1964 • 177 citations

The induction and repression of thymidine kinase in the poxvirus-infected HeLa cell

1963 • 177 citations

Carcinogens, Enzyme Induction, and Gene Action

1967 • 172 citations

Induction of Microsomal Enzyme Synthesis by Polycyclic Aromatic Hydrocarbons of Different Molecular Sizes

1961 • 166 citations

Site of action of cycloheximide in cells of Saccharomyces pastorianus

1964 • 163 citations

Conversion of P-450 to P-420 by neutral salts and some other reagents.

1967 • 150 citations

Conversion of P-450 to P-420 by Neutral Salts and some other Reagents

1967 • 132 citations

EFFECTS OF PHENOTHIAZINES ON PROTECTIVE SYSTEMS AGAINST POLYCYCLIC HYDROCARBONS.

1965 • 116 citations

Effects of 3-Methylcholanthrene and Phenobarbital on Amino Acid Incorporation into Protein

1961 • 106 citations

Effect of inhibitors of nucleic acid synthesis on steroid-mediated induction of tyrosine aminotransferase in hepatoma cell cultures

1967 • 105 citations

Puromycin: A potent metabolic effect independent of protein synthesis

1966 • 102 citations

Synthesis of nuclear and cytoplasmic RNA of HeLa cells and the effect of actinomycin D

1962 • 102 citations

The Hydroxylation of the Carcinogen 2-Acetylaminofluorene by Rat Liver: Stimulation by Pretreatment in Vivo with 3-Methylcholanthrene

1960 • 98 citations

STIMULATORY EFFECT OF CHRONIC DRUG ADMINISTRATION ON DRUG‐METABOLIZING ENZYMES IN LIVER MICROSOMES

1963 • 95 citations

Studies on the Regulation of Tyrosine Aminotransferase in Rats

1967 • 94 citations

Enzyme Induction by Corticosteroids in Embryonic Cells: Steroid Structure and Inductive Effect

1967 • 90 citations

Inductive effects of 3-methylcholanthrene on enzyme activities and amino acid incorporation capacity of rat liver microsomes

1960 • 85 citations

Intestinal Phosphatase Activity: Acceleration of Increase by Puromycin and Actinomycin

1964 • 82 citations

Induction of increased meprobamate metabolism in rats pretreated with some neurotropic drugs

1962 • 77 citations

Studies on the mechanism of drug-induced microsomal enzyme activities. V. Phenobarbital stimulation of endogenous messenger RNA and polyuridylic acid-directed L-[14C]-phenylalanine incorporation.

1966 • 74 citations

Growth Hormone Action on Rat Liver RNA Polymerase

1965 • 70 citations

Stimulatory effect of chlorcyclizine on barbiturate metabolism.

1961 • 61 citations

The regulation of enzyme synthesis by steroid hormones: The role of translation

1965 • 59 citations

Studies on the mechanism of methylcholanthrene induction of enzyme activities

1964 • 57 citations

The effect of carcinogenic hydrocarbons on rodent and primate cells in vitro

1965 • 56 citations

Benzpyrene Hydroxylase Induction by Polycyclic Hydrocarbons in Hamster Embryonic Cells Grown in vitro

1967 • 48 citations

Studies on the enzymic hydroxylation of 3,4-benzpyrene.

1967 • 40 citations

Studies on the 3-methylcholanthrene induction and carbohydrate repression of rat liver dimethylaminoazobenzene reductase

1965 • 39 citations

Studies on the control of enzyme synthesis during the early embryonic development of the sea urchins

1964 • 37 citations

Increased Sensitivity of Microsomes from Phenobarbital-Treated Rats to Synthetic Messenger RNA (Polyuridylic Acid): Lack of Effect on Ribosomes

1965 • 36 citations

ENZYME INDUCTION AND DRUG TOXICITY

1965 • 33 citations

METHYLCHOLANTHRENE-INDUCED CHANGES IN RAT LIVER NUCLEAR RNA

1964 • 31 citations

Studies on the Removal of Endogenous Messenger Ribonucleic Acid Activity from Rat Liver Microsomes

1967 • 28 citations

The stimulation of amino acid incorporation in a mammalian system with phenobarbital, 3-methylcholanthrene and cycloheximide

1966 • 27 citations

Studies on the mechanism of methylcholanthrene induction of enzyme activities of rat liver

1964 • 27 citations

Ribonucleic acid polymerase activity in liver nuclei from rats pretreated with 3-methylcholanthrene.

1966 • 27 citations

FORMATION AND CONVERSION OF MACROMOLECULAR PRECURSOR(S) IN THE BIOSYNTHESIS OF CARBAMYL PHOSPHATE SYNTHETASE

1965 • 21 citations

Alkaline phosphatase of human skin fibroblast cultures

1964 • 18 citations

The effect of methylchlanthrene, phenobarbital and aflatoxin on RNA polymerase of rat liver

1967 • 12 citations

Metibolic Behavior of Nucleic Acids in Subcellular Fractions from Liver of Rats Treated with Methylcholanthrene*

1964 • 8 citations

Environmental Factors Influencing the Hyperfine Structure of Manganous Low-Temperature Electron Paramagnetic Resonance Spectra

1966 • 6 citations