Structural Studies on Calmodulin and Troponin C: Phenothiazine, Peptide, and Protein Interactions with Calcium-Induced Helices

Carp Muscle Calcium-binding Protein

1973 • 1,359 citations

Calmodulin

1980 • 982 citations

The calcium and magnesium binding sites on troponin and their role in the regulation of myofibrillar adenosine triphosphatase.

1975 • 917 citations

Calmodulin

1982 • 771 citations

Calcium-binding proteins and calcium function

1977 • 742 citations

The complete amino acid sequence of the Ca2+-dependent modulator protein (calmodulin) of bovine brain.

1980 • 588 citations

Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

1977 • 544 citations

Calcium-induced exposure of a hydrophobic surface on calmodulin

1980 • 520 citations

Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+-Mg2+)ATPase

1977 • 483 citations

Conformational transition accompanying the binding of calcium(2+) ion to the protein activator of 3',5'-cyclic adenosine monophosphate phosphodiesterase

1977 • 472 citations

Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity

1977 • 459 citations

Partial purification of the Ca2+-Mg2+ ATPase activator from human erythrocytes: Its similarity to the activator of 3′:5′ — cyclic nucleotide phosphodiesterase

1977 • 395 citations

Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain.

1976 • 389 citations

Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

1979 • 378 citations

Hydrophobic regions function in calmodulin-enzyme(s) interactions.

1980 • 363 citations

Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.

1980 • 335 citations

Structure of vitamin D-dependent calcium-binding protein from bovine intestine

1981 • 309 citations

Interaction of drugs with calmodulin

1982 • 306 citations

Divalent cation binding properties of bovine brain Ca2+-dependent regulator protein.

1977 • 285 citations

A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii.

1979 • 278 citations

The Role of Calmodulin in the Structure and Regulation of Phosphorylase Kinase from Rabbit Skeletal Muscle

1979 • 267 citations

The amino acid sequence of rabbit skeletal muscle troponin C: Gene replication and homology with calcium ‐binding proteins from carp and hake muscle

1973 • 266 citations

Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.

1982 • 259 citations

The Regulation of Contractile Activity in Muscle

1979 • 212 citations

Proteolytic fragments of troponin C. Localization of high and low affinity Ca2+ binding sites and interactions with troponin I and troponin T

1978 • 209 citations

Specificity of the binding of trifluoperazine to the calcium-dependent activator of phosphodiesterase and to a series of other calcium-binding proteins

1978 • 207 citations

Agonist and antagonist properties of calmodulin fragments.

1984 • 198 citations

Ca2+-dependent high-affinity complex formation between calmodulin and melittin

1983 • 191 citations

Effect of the troponin C‐like protein from bovine brain (brain modulator protein) on the Mg²⁺‐stimulated ATPase of skeletal muscle actomyosin

1976 • 191 citations

Sequence homology of the Ca2+-dependent regulator of cyclic nucleotide phosphodiesterase from rat testis with other Ca2+-binding proteins.

1978 • 179 citations

Troponin C-like proteins (calmodulins) from mammalian smooth muscle and other tissues

1979 • 177 citations

Structural homology of myosin alkali light chains, troponin C and carp calcium binding protein

1974 • 171 citations

The Role of Calcium Ions, Calmodulin and Troponin in the Regulation of Phosphorylase Kinase from Rabbit Skeletal Muscle

1980 • 156 citations

High affinity binding of the mastoparans by calmodulin

1983 • 154 citations

Comparison of calcium-binding proteins. Bovine heart and brain protein activators of cyclic nucleotide phosphodiesterase and rabbit skeletal muscle troponin C.

1976 • 144 citations

Characterization of tryptic fragments obtained from bovine brain protein modulator of cyclic nucleotide phosphodiesterase.

1977 • 142 citations

Hydrodynamic and optical properties of troponin A. Demonstration of a conformational change upon binding calcium ion

1972 • 141 citations

Phenothiazine antagonism of calmodulin: A structurally-nonspecific interaction

1981 • 141 citations

Binding of simple peptides, hormones, and neurotransmitters by calmodulin

1982 • 139 citations

Biological cross-reactivity of rat testis phosphodiesterase activator protein and rabbit skeletal muscle troponin-C.

1977 • 139 citations

Proteolytic fragments of troponin C. Interactions with the other troponin subunits and biological activity.

1981 • 137 citations

Ionization constants and water solubilities of some aminoalkylphenothiazine tranquillizers and related compounds

1967 • 132 citations

Calcium-dependent affinity chromatography of S-100 and calmodulin on calmodulin antagonist-coupled Sepharose.

1981 • 131 citations

A ¹¹³Cd NMR study of calmodulin and its interaction with calcium, magnesium and trifluoperazine

1980 • 127 citations

Inhibition of calcium-dependent regulator-stimulated phosphodiesterase activity by neuroleptic drugs is unrelated to their clinical efficacy.

1979 • 125 citations

Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine.

1981 • 123 citations

Cadmium-113 nuclear magnetic resonance studies of proteolytic fragments of calmodulin: assignment of strong and weak cation binding sites

1983 • 119 citations

The amino acid sequence of the Tetrahymena calmodulin which specifically interacts with guanylate cyclase

1981 • 116 citations

Selective Alteration of the Activity of the Multiple Forms of Adenosine 3', 5'-Monophosphate Phosphodiesterase of Rat Cerebrum

1974 • 116 citations

Calcium binding domains of calmodulin. Sequence of fill as determined with terbium luminescence.

1982 • 113 citations

Calcium-induced protein folding. Structure-affinity relationships in synthetic analogs of the helix-loop-helix calcium binding unit.

1981 • 112 citations

Phosphorylase Kinase from Rabbit Skeletal Muscle Identification of the Calmodulin‐Binding Subunits

1980 • 112 citations

Determination of the free-energy coupling for binding of calcium ion and troponin I to calmodulin

1982 • 110 citations

Can calmodulin inhibitors be used to probe calmodulin effects?

1981 • 110 citations

Peptide binding by calmodulin and its proteolytic fragments and by troponin C

1984 • 106 citations

¹H‐NMR studies of calmodulin

1984 • 103 citations

Effect of Ca2+ binding on troponin C. Changes in spin label mobility, extrinsic fluorescence, and sulfhydryl reactivity.

1976 • 101 citations

Similarity in Ca2+-induced changes between troponin-C and protein activator of 3′:5′-cyclic nucleotide phosphodiesterase and their tryptic fragments

1977 • 96 citations

Co-operativity and calcium/magnesium binding to troponin C and muscle calcium binding parvalbumin: An hypothesis

1980 • 94 citations

A study of calmodulin and its interaction with trifluoperazine by high resolution ¹H NMR spectroscopy

1981 • 94 citations

Metal‐Binding Properties of Calmodulin

1982 • 94 citations

Calcium‐dependent hydrophobic interaction chromatography of calmodulin, troponin C and their proteolytic fragments

1983 • 92 citations

Binding of hormones and neuropeptides by calmodulin

1983 • 92 citations

A new mast cell degranulating peptide homologous to mastoparan in the venom of Japanese hornet (Vespa xanthoptera).

1979 • 86 citations

Ca²⁺, Mg²⁺dependent conformations of troponin C as determined by ¹H and ¹⁹F nuclear magnetic resonance

1977 • 85 citations

Terbium as luminescent probe of calmodulin calcium‐binding sites

1980 • 85 citations

The crystal and molecular structure of chlorpromazine

1969 • 84 citations

Characterization of a region of the primary sequence of troponin C involved in calcium ion-dependent interaction with troponin I

1978 • 82 citations

3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine, a hydrophobic, photoreactive probe, labels calmodulin and calmodulin fragments in a calcium(2+)-dependent way

1984 • 80 citations

Activation of phosphorylase kinase from rabbit skeletal muscle by calmodulin and troponin

1979 • 80 citations

Stimulation of enzyme activities by fragments of calmodulin

1981 • 75 citations

Primary sequence analysis and folding behavior of EF hands in relation to the mechanism of action of troponin C and calmodulin

1983 • 75 citations

Terbium binding to octopus calmodulin provides the complete sequence of ion binding

1980 • 73 citations

Ca++ induced conformational changes in the Ca++ binding component of troponin

1972 • 73 citations

Calmodulin

1982 • 71 citations

Muscle contraction. Its regulatory mechanisms

1982 • 71 citations

The effect of Mg++ on the conformation of the Ca++-binding component of troponin

1972 • 71 citations

STRUCTURE AND FUNCTION RELATIONSHIPS AMONG CALMODULINS AND TROPONIN C‐LIKE PROTEINS FROM DIVERGENT EUKARYOTIC ORGANISMS*

1980 • 65 citations

Relationship between pK_b(H₂O) of Organic Compounds and E _1∕2 Values in Several Nonaqueous Solvents.

1962 • 61 citations

Calcium-dependent inhibitory region of troponin: a proton nuclear magnetic resonance study on the interaction between troponin C and the synthetic peptide N.alpha.-acetyl[FPhe106]TnI-(104-115) amide

1983 • 61 citations

Homologous calcium-binding proteins in the activation of skeletal, cardiac, and smooth muscle myosin light chain kinases.

1980 • 59 citations

Calcium ion-dependent covalent modification of calmodulin with norchlorpromazine isothiocyanate

1983 • 58 citations

Calcium-induced conformational changes in a cyanogen bromide fragment of troponin C that contains one of the binding sites.

1978 • 57 citations

Demonstration by covalent cross-linking of a specific interaction between beta-endorphin and calmodulin.

1983 • 57 citations

Extent and localization of conformational changes in troponin C caused by calcium binding. Spectral studies in the presence and absence of 6 M urea.

1979 • 54 citations

Localization of a trifluoperazine binding site on troponin C

1983 • 53 citations

Biological activities of the peptides obtained by digestion of troponin C and calmodulin with thrombin

1981 • 53 citations

Circular dichroism studies of native and chemically modified Ca²⁺-dependent protein modulator

1979 • 50 citations

Lanthanide-induced peptide folding: variations in lanthanide affinity and induced peptide conformation

1983 • 49 citations

Comparison of the calcium- and magnesium-induced structural changes of troponin-C

1978 • 48 citations

A¹¹³Cd and ¹H NMR Study of the Interaction of Calmodulin with D600, Trifluoperazine and Some Other Hydrophobic Drugs

1983 • 47 citations

Localization of hydrophobic sites in calmodulin and skeletal muscle troponin C studied using tryptic fragments a simple method of their preparation

1983 • 47 citations

Proton magnetic resonance studies on proteolytic fragments of troponin-C. Structural homology with the native molecule

1980 • 47 citations

Synthetic analog of a high affinity calcium binding site in rabbit skeletal troponin C.

1980 • 46 citations

Allosteric interactions among drug binding sites on calmodulin

1983 • 44 citations

Identification and purification of a phenothiazine binding fragment from bovine brain calmodulin

1982 • 42 citations

High field proton NMR studies of tryptic fragments of calmodulin: A comparison with the native protein

1984 • 41 citations

A new heterobifunctional cross-linking reagent for the study of biological interactions between proteins. I. Design, synthesis, and characterization.

1981 • 41 citations

A Calmodulin-Like Ca2+ Receptor in the Ca2+ Channel

1984 • 40 citations

Laser photochemically induced dynamic nuclear polarization proton nuclear magnetic resonance studies on three homologous calcium binding proteins: cardiac troponin-C, skeletal troponin-C, and calmodulin

1981 • 39 citations

Hydrogen-1 nuclear magnetic resonance investigation of bovine cardiac troponin C. Comparison of tyrosyl assignments and calcium-induced structural changes to those of two homologous proteins, rabbit skeletal troponin C and bovine brain calmodulin

1981 • 38 citations

Proton nuclear magnetic resonance investigation of synthetic calcium-binding peptides

1982 • 37 citations

Degradation of TN-C component of troponin by trypsin

1977 • 34 citations

A new heterobifunctional cross-linking reagent for the study of biological interactions between proteins. II. Application to the troponin C-troponin I interaction.

1981 • 29 citations

Calcium binding by troponin-C and homologs is correlated with the position and linear density of “β-turn forming” residues

1979 • 27 citations

Synthetic peptide analogs of skeletal troponin C: Fluorescence studies of analogs of the low-affinity calcium-binding site II

1983 • 24 citations

Secondary-structure predictions of calcium-binding proteins

1977 • 23 citations

Cation dependent conformations of brain Ca2+-dependent regulator protein detected by nuclear magnetic resonance

1979 • 23 citations

Specificity of Tetrahymena calmodulin in activation of calmodulin‐regulated enzymes

1982 • 19 citations

Trifluoperazine hydrochloride, a phenothiazine derivative

1980 • 15 citations

Hydrophobic properties of Tetrahymena calmodulin related to the phosphodiesterase activity

1983 • 14 citations

α-Flupenthixol

1975 • 12 citations

Interaction of neuroleptic drugs with a synthetic calcium‐binding peptide analog of site III of rabbit skeletal troponin C

1983 • 11 citations

Studies of the interaction of troponin I with proteins of the I-filament and calmodulin

1983 • 8 citations