Profilierung zirkulierender Tumorzellen mit Apparaturen und Materialien der nächsten Generation

Hallmarks of Cancer: The Next Generation

2011 • 58,651 citations

The Hallmarks of Cancer

2000 • 27,569 citations

A Perspective on Cancer Cell Metastasis

2011 • 4,414 citations

Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer

2004 • 4,315 citations

Cancer Metastasis: Building a Framework

2006 • 4,071 citations

Isolation of rare circulating tumour cells in cancer patients by microchip technology

2007 • 3,431 citations

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

2013 • 2,242 citations

Tumour heterogeneity and cancer cell plasticity

2013 • 2,241 citations

Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer

2008 • 2,109 citations

Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer

2008 • 1,766 citations

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

2010 • 1,559 citations

Challenges in circulating tumour cell research

2014 • 1,169 citations

Tumour heterogeneity in the clinic

2013 • 1,102 citations

Detection, clinical relevance and specific biological properties of disseminating tumour cells

2008 • 1,098 citations

Circulating Tumor Cells: Liquid Biopsy of Cancer

2012 • 1,042 citations

Isolation by Size of Epithelial Tumor Cells

2000 • 1,024 citations

Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells

2013 • 1,012 citations

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

2013 • 978 citations

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

2014 • 840 citations

Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non–Small-Cell Lung Cancer

2011 • 839 citations

A case of cancer in which cells similar to those in the tumours were seen in the blood after death

1869 • 824 citations

Clinical Significance and Molecular Characteristics of Circulating Tumor Cells and Circulating Tumor Microemboli in Patients With Small-Cell Lung Cancer

2012 • 800 citations

Microfluidic, marker-free isolation of circulating tumor cells from blood samples

2014 • 690 citations

Detection and characterization of carcinoma cells in the blood

1998 • 684 citations

A microfluidic device for label-free, physical capture of circulating tumor cell clusters

2015 • 665 citations

Circulating Tumor Cells

2013 • 663 citations

Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers

2011 • 600 citations

Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells

2007 • 592 citations

Molecular analysis of circulating tumour cells—biology and biomarkers

2014 • 583 citations

In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells

2009 • 562 citations

Deformability-based cell classification and enrichment using inertial microfluidics

2011 • 552 citations

Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines

2012 • 514 citations

Highly Efficient Circulating Tumor Cell Isolation from Whole Blood and Label-Free Enumeration Using Polymer-Based Microfluidics with an Integrated Conductivity Sensor

2008 • 513 citations

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

2014 • 510 citations

Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets

2013 • 508 citations

Three‐Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells

2009 • 494 citations

Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

2013 • 492 citations

The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis

2013 • 480 citations

Size-selective collection of circulating tumor cells using Vortex technology

2013 • 479 citations

The biology of circulating tumor cells

2015 • 478 citations

Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device

2009 • 470 citations

Portable Filter-Based Microdevice for Detection and Characterization of Circulating Tumor Cells

2010 • 441 citations

Isolation of rare cells from cell mixtures by dielectrophoresis

2009 • 428 citations

Continuous separation of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP)

2011 • 418 citations

Micromachine‐Enabled Capture and Isolation of Cancer Cells in Complex Media

2011 • 403 citations

A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas

2011 • 386 citations

Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays

2010 • 322 citations

Electrospun TiO₂ Nanofiber‐Based Cell Capture Assay for Detecting Circulating Tumor Cells from Colorectal and Gastric Cancer Patients

2012 • 319 citations

A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire

2012 • 305 citations

Specific Capture and Release of Circulating Tumor Cells Using Aptamer‐Modified Nanosubstrates

2013 • 289 citations

In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry

2007 • 288 citations

Bioinspired multivalent DNA network for capture and release of cells

2012 • 270 citations

A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells

2012 • 268 citations

Capture and Stimulated Release of Circulating Tumor Cells on Polymer‐Grafted Silicon Nanostructures

2012 • 256 citations

Technologies for detection of circulating tumor cells: facts and vision

2013 • 247 citations

Quick-Response Magnetic Nanospheres for Rapid, Efficient Capture and Sensitive Detection of Circulating Tumor Cells

2013 • 238 citations

Molecular profiling of single circulating tumor cells with diagnostic intention

2014 • 237 citations

Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector

2012 • 234 citations

Emerging Role of Nanomaterials in Circulating Tumor Cell Isolation and Analysis

2014 • 232 citations

Aptamer-Enabled Efficient Isolation of Cancer Cells from Whole Blood Using a Microfluidic Device

2012 • 221 citations

Multivalent DNA Nanospheres for Enhanced Capture of Cancer Cells in Microfluidic Devices

2013 • 215 citations

Nanostructure Embedded Microchips for Detection, Isolation, and Characterization of Circulating Tumor Cells

2014 • 210 citations

NanoFlares for the detection, isolation, and culture of live tumor cells from human blood

2014 • 205 citations

Polymer Nanofiber‐Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells

2013 • 202 citations

High-purity and label-free isolation of circulating tumor cells (CTCs) in a microfluidic platform by using optically-induced-dielectrophoretic (ODEP) force

2013 • 200 citations

A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer

2011 • 193 citations

Challenges in the Enumeration and Phenotyping of CTC

2012 • 183 citations

High-Throughput Selection, Enumeration, Electrokinetic Manipulation, and Molecular Profiling of Low-Abundance Circulating Tumor Cells Using a Microfluidic System

2011 • 178 citations

Aptamer‐Functionalized Barcode Particles for the Capture and Detection of Multiple Types of Circulating Tumor Cells

2014 • 172 citations

Circulating Tumor Cells As Prognostic Markers in Neuroendocrine Tumors

2012 • 170 citations

Collective and individual migration following the epithelial–mesenchymal transition

2014 • 168 citations

Functionalized Conducting Polymer Nanodots for Enhanced Cell Capturing: The Synergistic Effect of Capture Agents and Nanostructures

2011 • 166 citations

Dendrimer‐Mediated Multivalent Binding for the Enhanced Capture of Tumor Cells

2011 • 161 citations

Enrichment, detection and clinical significance of circulating tumor cells

2013 • 159 citations

Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells

2015 • 153 citations

High‐Purity Prostate Circulating Tumor Cell Isolation by a Polymer Nanofiber‐Embedded Microchip for Whole Exome Sequencing

2013 • 149 citations

Nanoparticle‐Mediated Binning and Profiling of Heterogeneous Circulating Tumor Cell Subpopulations

2014 • 134 citations

Biomarker Utility of Circulating Tumor Cells in Metastatic Cutaneous Melanoma

2012 • 130 citations

Heterogeneity of Estrogen Receptor Expression in Circulating Tumor Cells from Metastatic Breast Cancer Patients

2013 • 125 citations

Programming Thermoresponsiveness of NanoVelcro Substrates Enables Effective Purification of Circulating Tumor Cells in Lung Cancer Patients

2014 • 123 citations

Optical tracking and detection of immunomagnetically selected and aligned cells

1999 • 118 citations

Three‐Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells

2009 • 114 citations

Highly Specific Electrochemical Analysis of Cancer Cells using Multi‐Nanoparticle Labeling

2014 • 111 citations

Capture, isolation and release of cancer cells with aptamer-functionalized glass bead array

2012 • 106 citations

Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

2014 • 104 citations

A sieve for the isolation of cancer cells and other large cells from the blood

1964 • 103 citations

Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases

2015 • 97 citations

Sensitive and High‐Throughput Isolation of Rare Cells from Peripheral Blood with Ensemble‐Decision Aliquot Ranking

2012 • 96 citations

Multiscale immunomagnetic enrichment of circulating tumor cells: from tubes to microchips

2013 • 86 citations

Efficiency of whole genome amplification of single circulating tumor cells enriched by CellSearch and sorted by FACS

2013 • 86 citations

Micromachine‐Enabled Capture and Isolation of Cancer Cells in Complex Media

2011 • 83 citations

Efficient Isolation and Accurate In Situ Analysis of Circulating Tumor Cells Using Detachable Beads and a High‐Pore‐Density Filter

2013 • 78 citations

Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells

2013 • 76 citations

Dual-Aptamer Modification Generates a Unique Interface for Highly Sensitive and Specific Electrochemical Detection of Tumor Cells

2014 • 74 citations

Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers

2011 • 72 citations

High purity microfluidic sorting and analysis of circulating tumor cells: towards routine mutation detection

2015 • 66 citations

Mesenchymal‐Mode Migration Assay and Antimetastatic Drug Screening with High‐Throughput Microfluidic Channel Networks

2014 • 62 citations

In Situ Electrochemical ELISA for Specific Identification of Captured Cancer Cells

2015 • 62 citations

Detection of Circulating Cancer Cells Using Electrocatalytic Gold Nanoparticles

2012 • 60 citations

Engineered Decomposable Multifunctional Nanobioprobes for Capture and Release of Rare Cancer Cells

2014 • 58 citations

Rapid and specific electrochemical detection of prostate cancer cells using an aperture sensor array

2013 • 55 citations

High-Throughput 3D Cell Invasion Chip Enables Accurate Cancer Metastatic Assays

2014 • 39 citations

Sample-to-Answer Isolation and mRNA Profiling of Circulating Tumor Cells

2015 • 38 citations

Immunobead filtration: a novel approach for the isolation and propagation of tumor cells.

1997 • 35 citations

Velocity valleys enable efficient capture and spatial sorting of nanoparticle-bound cancer cells

2015 • 35 citations

Detection of rare circulating breast cancer cells by filtration cytometry and identification by DNA content: sensitivity in an experimental model.

1997 • 31 citations

Nanoparticle‐Mediated Binning and Profiling of Heterogeneous Circulating Tumor Cell Subpopulations

2014 • 29 citations

Dendrimer-Mediated Multivalent Binding for the Enhanced Capture of Tumor Cells

2011 • 28 citations

Nanoparticle-based sorting of circulating tumor cells by epithelial antigen expression during disease progression in an animal model

2015 • 27 citations

Polymer Nanofiber‐Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells

2013 • 24 citations

Highly Specific Electrochemical Analysis of Cancer Cells using Multi‐Nanoparticle Labeling

2014 • 23 citations

Sensitive and High‐Throughput Isolation of Rare Cells from Peripheral Blood with Ensemble‐Decision Aliquot Ranking

2012 • 15 citations

Mesenchymal‐Mode Migration Assay and Antimetastatic Drug Screening with High‐Throughput Microfluidic Channel Networks

2014 • 14 citations

Efficient Isolation and Accurate In Situ Analysis of Circulating Tumor Cells Using Detachable Beads and a High-Pore-Density Filter

2013 • 14 citations

Mikroraketen mit Eigenantrieb zum Einfangen und Isolieren zirkulierender Tumorzellen

2011 • 4 citations