Clinical Implications of Enzyme Induction

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

PLASMA-PARACETAMOL HALF-LIFE AND HEPATIC NECROSIS IN PATIENTS WITH PARACETAMOL OVERDOSAGE

1971 • 610 citations

Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma

1973 • 601 citations

Medical Treatment of Osteoarthritis

1965 • 554 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

Osteomalacia with Long-term Anticonvulsant Therapy in Epilepsy

1970 • 427 citations

Hepatic Microsomal Enzymes in Man and Rat: Induction and Inhibition by Ethanol

1968 • 331 citations

Benzpyrene hydroxylase activity in the gastrointestinal tract.

1962 • 328 citations

Phenobarbital-Induced Alterations in Vitamin D Metabolism

1972 • 308 citations

Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds

1967 • 266 citations

Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital

1966 • 260 citations

Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes.

1973 • 248 citations

Blood Levels of Drug at the Equilibrium State after Multiple Dosing

1965 • 245 citations

Drug interactions in man

1965 • 235 citations

Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man

1969 • 224 citations

PREVENTION OF ENDEMIC GOITRE

1965 • 221 citations

HÆMOPHILIA CARRIERS

1974 • 214 citations

Inhibition of drug metabolism by acute ethanol intoxication

1970 • 211 citations

PLASMA GAMMA-GLUTAMYL TRANSPEPTIDASE ELEVATION IN PATIENTS RECEIVING'ENZYME-INDUCING DRUGS

1971 • 196 citations

PHENYLBUTAZONE AND ISONIAZID METABOLISM IN PATIENTS WITH LIVER DISEASE IN RELATION TO PREVIOUS DRUG THERAPY

1968 • 196 citations

Cigarette Smoking: Stimulatory Effect on Metabolism of 3,4-Benzpyrene by Enzymes in Human Placenta

1968 • 194 citations

THE STORY OF VITAMIN D FROM VITAMIN TO HORMONE

1974 • 182 citations

Effect of environmental factors on drug metabolism: Decreased plasma half‐life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides

1969 • 179 citations

Delta-9-Tetrahydrocannabinol: Metabolism and Disposition in Long-Term Marihuana Smokers

1971 • 178 citations

URINARY D-GLUCARIC-ACID EXCRETION AS A TEST FOR HEPATIC ENZYME INDUCTION IN MAN

1971 • 172 citations

Effect of Diphenylhydantoin on Cortisol Metabolism in Man *

1964 • 169 citations

Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subiects

1970 • 153 citations

Effect of cigarette smoking on phenacetin metabolism

1974 • 133 citations

Changes in Plasma -Glutamyl Transpeptidase Activity Associated with Alterations in Drug Metabolism in Man

1973 • 125 citations

Chemoprophylaxis of carcinogenesis: a review.

1966 • 124 citations

Disturbances of liver porphyrin metabolism caused by drugs.

1967 • 124 citations

6β-HYDROXYCORTISOL AND OTHER POLAR CORTICOSTEROIDS: MEASUREMENT AND SIGNIFICANCE IN HUMAN URINE*†

1961 • 118 citations

EFFECTS OF PHENOTHIAZINES ON PROTECTIVE SYSTEMS AGAINST POLYCYCLIC HYDROCARBONS.

1965 • 116 citations

Effect of phenobarbital on the excretion of an exogenous bilirubin load

1967 • 114 citations

An Effect of o,p′-DDD on the Extra-adrenal Metabolism of Cortisol in Man

1964 • 112 citations

KINETICS AND CLINICAL IMPORTANCE OF DISPLACEMENT OF WARFARIN FROM ALBUMIN BY ACIDIC DRUGS*

1971 • 108 citations

INTERACTION BETWEEN PHENOBARBITAL AND DIPHENYLHYDANTOIN IN ANIMALS AND IN EPILEPTIC PATIENTS*

1971 • 104 citations

Enzyme Induction in Man caused by Smoking

1967 • 103 citations

Increased Cholesterol Biosynthesis Following Phenobarbital Induced Hypertrophy of Agranular Endoplasmic Reticulum in Liver.

1965 • 101 citations

THE INFLUENCE OF BARBITURATES ON COUMARIN PLASMA LEVELS AND PROTHROMBIN RESPONSE*

1961 • 99 citations

TREATMENT OF GILBERT'S SYNDROME WITH PHENOBARBITONE

1970 • 98 citations

The effects of phenobarbital, chloral betaine, and glutethimide administration on warfarin plasma levels and hypoprothrombinemic responses in man

1969 • 94 citations

Human brain, cerebrospinal fluid, and plasma concentrations of diphenylhydantoin and phenobarbital

1974 • 92 citations

Changes in liver blood flow during enzyme induction

1971 • 91 citations

CLINICAL IMPLICATIONS OF ENZYME INDUCTION

1971 • 90 citations

Evidence for the function of D-glucaric acid as an indicator for drug induced enhanced metabolism through the glucuronic acid pathway in man

1965 • 87 citations

Phenobarbital-Induced Increase in 6β-Hydroxycortisol Excretion: Clue to Its Significance in Human Urine1

1965 • 83 citations

Urinary D-glucaric acid excretion and total liver content of cytochrome P-450 in guinea-pigs: Relationship during enzyme induction and following inhibition of protein synthesis

1973 • 76 citations

Alcohol‐Drugs Interaction in Man: Alcohol and Tolbutamide*

1971 • 75 citations

Accelerated aminopyrine metabolism in human subjects pretreated with phenylbutazone

1962 • 73 citations

Griseofulvin-Phenobarbital Interaction in Man

1970 • 70 citations

Inducibility of benzo [α] pyrene hydroxylase in human skin by polycyclic hydrocarbons

1973 • 70 citations

The Effect of Spironolactone on Antipyrine Metabolism in Man

1973 • 70 citations

Die Beschleunigung des Evipanabbaues unter der Wirkung von Barbituraten

1958 • 69 citations

Increased Hepatic Microsomal Enzyme Activity from Occupational Exposure to Certain Organochlorine Pesticides

1972 • 69 citations

Dose‐dependent enzyme induction

1973 • 67 citations

Effect of diphenylhydantoin on cortisol kinetics in humans.

1971 • 64 citations

Interactions of Benzodiazepines with Warfarin

1972 • 62 citations

Drug Interactions with Warfarin: Studies with Dichloralphenazone, Chloral Hydrate and Phenazone (Antipyrine)

1971 • 60 citations

Stimulatory effect of N-phenylbarbital (phetharbital) on cortisol hydroxylation in man

1968 • 59 citations

Interaction between Doxycycline and Barbiturates

1974 • 58 citations

Altered Bile Acid Metabolism during Treatment with Phenobarbitone

1973 • 54 citations

Effect of heptabarbital on the response to bishydroxycoumarin in man.

1969 • 54 citations

ATMOSPHERIC POLLUTION AND PENTAZOCINE METABOLISM*1

1971 • 53 citations

REDUCTION OF SERUM-UNCONJUGATED-BILIRUBIN WITH PHENOBARBITONE IN ADULT CONGENITAL NON-HÆMOLYTIC UNCONJUGATED HYPERBILIRUBINÆMIA

1968 • 53 citations

γ-Glutamyl Transpeptidase: a Clinical and Experimental Study

1972 • 52 citations

THE EFFECT OF PHENOBARBITAL ADMINISTRATION ON THE CONTROL OF COAGULATION ACHIEVED DURING WARFARIN THERAPY IN MAN

1966 • 51 citations

Prediction of drug oxidation rates in man: Lack of correlation with serum gamma-glutamyl transpeptidase and urinary excretion of D-glucaric acid and 6?-hydroxycortisol

1974 • 50 citations

Drug Interactions With Warfarin

1968 • 49 citations

Interaction of Commonly Prescribed Drugs and Warfarin

1970 • 47 citations

Remission in Cushing's Syndrome with o,p′-DDD1

1966 • 46 citations

TREATMENT OF CHRONIC INTRAHEPATIC CHOLESTASIS WITH PHENOBARBITONE

1967 • 45 citations

Diphenylhydantoin effect on neonatal and adult rat hepatic drug metabolism.

1970 • 43 citations

PROGESTERONE EFFECTS ON GALACTOSE METABOLISM IN PREPUBERTAL PATIENTS WITH CONGENITAL GALACTOSEMIA AND IN RATS MAINTAINED ON HIGH GALACTOSE DIETS*

1960 • 42 citations

Effect of N-Phenylbarbital (Phetharbital) on the Metabolism of Testosterone and Cortisol in Man

1969 • 41 citations

Enzymatic regulation of bile acid synthesis

1971 • 41 citations

BACTERÆMIC SHOCK

1974 • 41 citations

Drug‐metabolizing capacity in states of drug dependence and withdrawal

1972 • 38 citations

Immediate decrease by hydrocortisone of the plasma half‐life of antipyrine

1973 • 35 citations

Effect of Phenobarbital and Glutethimide on Biological Half-Life of Warfarin

1966 • 34 citations

The measurement, excretion, and source of urinary 6-hydroxycortisol in humans

1969 • 34 citations

Induction of Increased Benzpyrene Hydroxylase Activity in Pulmonary Tissue in Vitro

1968 • 32 citations

Detoxication mechanisms in man

1963 • 32 citations

Spironolactone—a weak enzyme inducer in man

1972 • 31 citations

Effect of physicochemical and pharmacokinetic properties of barbiturates on the induction of drug metabolism

1973 • 28 citations

DRUG METABOLISM IN MAN: PAST, PRESENT, AND FUTURE

1971 • 22 citations

Progestational Activity of Certain Steroid-17-Spirolactones

1958 • 20 citations

Effect of butabarbital on orally administered anticoagulants.

1968 • 19 citations

Further observations on the interactions between phenobarbital and diphenyl-hydantoin during chronic treatment in the rat

1972 • 18 citations

Increased Glucuronidation of Bilirubin in Man and Rat by Administration of Antipyrine (Phenazone)

1974 • 17 citations

APPARENT RESISTANCE TO ORAL ANTICOAGULANT THERAPY AND INFLUENCE OF HYPNOTICS ON SOME COAGULATION FACTORS

1968 • 14 citations

Effect of Some Drugs on Lactonase Activity of Rat Liver

1961 • 10 citations

The effect of some sedatives (phenobarbital, gluthetimide, chlordiazepoxide, chloral hydrate) on the rate of disappearance of ethyl biscoumacetate from the plasma.

1967 • 8 citations

NON-SPECIFICITY OF PROLACTIN ASSAY BASED ON LUTEOTROPHIC EFFECT IN MATURE MICE

1968 • 5 citations