RECENT ADVANCES IN THE CHEMOTHERAPY OF LEPROSY

THE EXPERIMENTAL DISEASE THAT FOLLOWS THE INJECTION OF HUMAN LEPROSY BACILLI INTO FOOT-PADS OF MICE

1960 • 590 citations

Structure-activity relationships of the fluoroquinolones

1989 • 280 citations

Enhanced Susceptibility of Thymectomized and Irradiated Mice to Infection with Mycobacterium leprae

1966 • 120 citations

A rapid method for the detection of potentially viable Mycobacterium leprae in human biopsies: a novel application of PCR

1989 • 108 citations

Clinical trial of pefloxacin and ofloxacin in the treatment of lepromatous leprosy.

1990 • 92 citations

Drug resistance in leprosy - a review

1985 • 89 citations

Growth of Mycobacterium leprae and M. marinum in congenitally athymic (nude) mice

1976 • 87 citations

Oxidation of palmitic acid by Mycobacterium leprae in an axenic medium

1988 • 71 citations

In vitro and in vivo activities of macrolides against Mycobacterium leprae

1988 • 66 citations

Activity of Minocycline in Mycobacterium leprae--Infected Mice

1987 • 62 citations

Effect of Several Anti-Leprosy Drugs on Multiplication of Human Leprosy Bacilli in Foot-Pads of Mice

1962 • 53 citations

Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system

1989 • 50 citations

Rifampicin for lepromatous leprosy: nine years' experience.

1978 • 46 citations

Comparative in vitro activities of 20 fluoroquinolones against Mycobacterium leprae

1990 • 46 citations

A kinetic method for the study of activity of drugs against Mycobacterium leprae in mice.

1967 • 45 citations

The "Proportional Bactericidal Test": A Method for Assessing Bactericidal Activity of Drugs AgainsMycobacterium lepraein Mice

1978 • 39 citations

Activity of ofloxacin against Mycobacterium leprae in the mouse.

1988 • 39 citations

A brief review of experiences with short-term clinical trials monitored by mouse-foot-pad inoculation

1981 • 35 citations

Structure-activity relationships of tetramethylpiperidine-substituted phenazines against Mycobacterium leprae in vitro

1989 • 35 citations

Rapid in vitro metabolic screen for antileprosy compounds

1987 • 33 citations

Structure-activity relationships of selected phenazines against Mycobacterium leprae in vitro

1988 • 33 citations

Activities of pefloxacin and ciprofloxacin against Mycobacterium leprae in the mouse.

1987 • 32 citations

Lepromatoid Lesion Developed in Nude Mouse Inoculated with Mycobacterium leprae

1976 • 27 citations

Relapse or late reversal reaction?

1990 • 26 citations

In vitro and in vivo activities of ofloxacin against Mycobacterium leprae infection induced in mice.

1986 • 24 citations

Preliminary appraisal of a WHO-recommended multiple drug regimen in paucibacillary leprosy patients in Malawi.

1988 • 24 citations

Effectiveness of pefloxacin in the treatment of lepromatous leprosy.

1990 • 24 citations

Rapid, radiolabeled macrophage culture method for detection of dapsone-resistant Mycobacterium leprae

1982 • 23 citations

Clofazimine and dapsone compliance in leprosy

1988 • 22 citations

Uptake of radioactive DOPA by M. leprae

1974 • 22 citations

Metabolism of Mycobacterium leprae in macrophages

1987 • 22 citations

Kinetic Testing of Drugs Against Mycobacterium Leprae in Mice

1971 • 20 citations

Metabolism in Mycobacterium leprae: its relation to other research on M. leprae and to aspects of metabolism in other mycobacteria and intracellular parasites.

1984 • 19 citations

Operational aspects of multidrug therapy.

1989 • 18 citations

Neonatally thymectomized Lewis rats infected with Mycobacterium leprae: response to primary infection, secondary challenge, and large inocula

1976 • 17 citations

Axenic incorporation of [U-¹⁴C]palmitic acid into the phenolic glycolipid-I ofMycobacterium leprae

1987 • 14 citations

Susceptibility of strains of Mycobacterium leprae isolated prior to 1977 from patients with previously untreated lepromatous leprosy.

1986 • 14 citations

Inhibition of phenolic glycolipid-I synthesis in extracellular Mycobacterium leprae as an indicator of antimicrobial activity.

1988 • 13 citations

Antimycobacterial activities of two newer ansamycins, R-76-1 and DL 473.

1986 • 13 citations

Adenosine triphosphate content of Mycobacterium leprae from leprosy patients.

1984 • 12 citations

Impact of MDT on leprosy as measured by selective indicators

1988 • 11 citations

Relapse or late reversal reaction?

1989 • 11 citations

The bactericidal activity of various aminoglycoside antibiotics against Mycobacterium leprae in mice

1984 • 10 citations

Measurement of hypoxanthine incorporation in purified suspensions of Mycobacterium leprae: a suitable method to screen for anti-leprosy agents in vitro

1988 • 10 citations

Wall biosynthesis: a possible site of action for new antimycobacterial drugs.

1984 • 9 citations

Primary and secondary dapsone resistance of M. leprae in Martinique, Guadeloupe, New Caledonia, Tahiti, Senegal, and Paris between 1980 and 1985.

1987 • 9 citations

Detection of persisting Mycobacterium leprae by inoculation of the neonatally thymectomized rat.

1987 • 8 citations

Further studies of the killing of M. leprae by aminoglycosides: reduced dosage and frequency of administration.

1987 • 8 citations

Host-pathogen interaction-new in vitro drug test systems againstMycobacterium leprae- possibilities and limitations

1986 • 6 citations

Evaluation of the Activity of Streptomycin onMycobacterium lepraein Mice

1978 • 5 citations

Further studies of the killing of M. leprae by aminoglycosides: reduced dosage and frequency of administration.

1987 • 5 citations

The use of rodent models in assessing antimicrobial activity againstMycobacterium leprae

1986 • 5 citations

Axenic incorporation of [U-14C]palmitic acid into the phenolic glycolipid-I of Mycobacterium leprae

1987 • 4 citations

Single bacterial cell mass analysis: a rapid test method in leprosy therapy control

1986 • 4 citations

Primary dapsone resistance in China

1989 • 3 citations

Screening of drugs for activity against Mycobacterium leprae.

1987 • 2 citations