Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study.

Microdialysis—Theory and application

1990 • 651 citations

A microdialysis method allowing characterization of intercellular water space in humans

1987 • 649 citations

Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro

1990 • 501 citations

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies

1997 • 317 citations

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study

1991 • 303 citations

Application of microdialysis in pharmacokinetic studies.

1997 • 300 citations

Mass transfer in brain dialysis devices—a new method for the estimation of extracellular amino acids concentration

1985 • 299 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Quantitative microdialysis of neurotransmitters

1993 • 276 citations

In vivo calibration of microdialysis probes for exogenous compounds

1992 • 218 citations

Intracerebral microdialysis: I. Experimental studies of diffusion kinetics

1989 • 218 citations

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method.

1997 • 176 citations

Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.

1989 • 164 citations

A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis

1991 • 161 citations

Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man

1995 • 155 citations

The simultaneous estimation of the influx and efflux blood-brain barrier permeabilities of gabapentin using a microdialysis-pharmacokinetic approach.

1996 • 127 citations

Central nervous system effects of subdissociative doses of (S)-ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers*

1995 • 121 citations

Learning deficits induced by chronic intraventricular infusion of quinolinic acid — protection by MK-801 and memantine

1996 • 103 citations

Protection after Transient Focal Cerebral Ischemia by the N-Methyl-d-Aspartate Antagonist Dextrorphan is Dependent upon Plasma and Brain Levels

1991 • 60 citations

Structure-anti-Parkinson activity relationships in the aminoadamantanes. Influence of bridgehead substitution

1982 • 59 citations

The effects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis

1996 • 53 citations

Microdialysis studies of the distribution of stavudine into the central nervous system in the freely-moving rat.

1997 • 51 citations

Practical aspects of using microdialysis for determination of brain interstitial concentrations

1991 • 47 citations

Evidence for Lysosomotropism of Memantine in Cultured Human Cells: Cellular Kinetics and Effects of Memantine on Phospholipid Content and Composition, Membrane Fluidity and β‐Adrenergic Transmission

1993 • 41 citations

The use of microdialysis in pharmacokinetics and pharmacodynamics

1991 • 39 citations

Determination of extracellular methotrexate tissue levels by microdialysis in a rat model

1996 • 21 citations

Determination of serum and brain concentrations of neuroprotective and non-neuroprotective doses of MK-801

1993 • 17 citations