Prediction of Recurrence for Advanced Breast Cancer

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up

1991 • 5,979 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases

1989 • 2,245 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors

1989 • 1,471 citations

Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells

1984 • 1,416 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

Diagnostic Histopathology of the Breast

1988 • 1,083 citations

The Nottingham prognostic index in primary breast cancer

1992 • 1,051 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Effects of Adjuvant Tamoxifen and of Cytotoxic Therapy on Mortality in Early Breast Cancer

1988 • 921 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Treatment of Early-Stage Breast Cancer

1991 • 763 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

The value of estrogen and progesterone receptors in the treatment of breast cancer

1980 • 735 citations

Cloning of the human estrogen receptor cDNA.

1985 • 720 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

A prognostic index in primary breast cancer

1982 • 687 citations

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization.

1966 • 680 citations

Assessment of response to therapy in advanced breast cancer.A project of the programme on clinical oncology of the International Union against Cancer, Geneva, Switzerland

1977 • 633 citations

Estrogen Receptors in Human Breast Cancer

1976 • 621 citations

Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer.

1990 • 602 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

Prediction of Relapse or Survival in Patients with Node-Negative Breast Cancer by DNA Flow Cytometry

1989 • 571 citations

Predicting Response to Endocrine Therapy in Human Breast Cancer: A Hypothesis

1975 • 570 citations

Microvessel quantitation and prognosis in invasive breast carcinoma

1992 • 566 citations

Adjuvant Therapy of Cancer

1990 • 534 citations

Cancer of the breast: Size of neoplasm and prognosis

1969 • 491 citations

HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma.

1992 • 466 citations

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA

1987 • 419 citations

Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node negative breast cancer patients: findings from National Surgical Adjuvant Breast and Bowel Project Protocol B-06.

1988 • 415 citations

A Randomized Clinical Trial Evaluating Sequential Methotrexate and Fluorouracil in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor-Negative Tumors

1989 • 400 citations

A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma.

1989 • 385 citations

Progesterone Receptors as a Prognostic Factor in Stage II Breast Cancer

1983 • 372 citations

Ten year follow-up results of patients with carcinoma of the breast in a co-operative clinical trial evaluating surgical adjuvant chemotherapy.

1975 • 367 citations

Heat Shock Protein hsp70 in Patients With Axillary Lymph Node-Negative Breast Cancer: Prognostic Implications

1993 • 361 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

Efficacy of Adjuvant Chemotherapy in High-Risk Node-Negative Breast Cancer

1989 • 359 citations

Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years.

1989 • 357 citations

Breast cancer: Relationship between the size of the primary tumour and the probability of metastatic dissemination

1984 • 354 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Indicators of Prognosis in Node-Negative Breast Cancer

1990 • 348 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

Inhibition of human mammary and prostatic cancers by adrenalectomy.

1952 • 327 citations

Micrometastases to axillary lymph nodes from carcinoma of breast: Detection by immunohistochemistry and prognostic significance

1987 • 311 citations

DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens

1988 • 301 citations

Expression of the Antimetastatic Gene nm23 in Human Breast Cancer: An Association WIth Good Prognosis

1991 • 298 citations

Association of DNA index and S-phase fraction with prognosis of nodes positive early breast cancer.

1987 • 263 citations

Ki-67 immunostaining in human breast tumors and its relationship to prognosis

1991 • 258 citations

Pathologic findings from the national surgical adjuvant project for breast cancers (protocol no. 4) X. Discriminants for tenth year treatment failure

1984 • 252 citations

Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.

1989 • 250 citations

Maintenance of p53 alterations throughout breast cancer progression.

1991 • 244 citations

Localization of Progesterone Receptor with Monoclonal Antibodies to the Human Progestin Receptor*

1988 • 230 citations

Prediction of early course of breast carcinoma by thymidine labeling

1983 • 230 citations

Steroid receptors and other prognostic factors in primary breast cancer.

1988 • 227 citations

Improving the prognostic value of DNA flow cytometry in breast cancer by combining DNA index and S-phase fraction: A proposed classification of DNA histograms in breast cancer

1988 • 226 citations

The long‐term prognostic significance of the thymidine labelling index in breast cancer

1984 • 225 citations

Nuclear structure in cancer tissues.

1957 • 222 citations

Mitosis counting in tumors

1990 • 213 citations

Histologic grading of breast carcinoma. A reproducibility study

1994 • 212 citations

Risk of Internal Mammary Lymph Node Metastases and Its Relevance on Prognosis of Breast Cancer Patients

1983 • 211 citations

Consensus review of the clinical utility of dna cytometry in carcinoma of the breast

1993 • 196 citations

Epidermal growth factor receptors in human breast cancer

1984 • 190 citations

Prognosis in Carcinoma of the Breast

1950 • 184 citations

Monoclonal antibodies as probes for estrogen receptor detection and characterization

1982 • 181 citations

Histologic grading of breast cancer.

1980 • 177 citations

Tumour DNA ploidy as an independent prognostic factor in breast cancer

1987 • 174 citations

Amplification of the int-2 gene in primary human breast tumors.

1988 • 172 citations

Ki-67 immunostaining in node-negative stage I/II breast carcinoma. Significant correlation with prognosis

1991 • 172 citations

Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival

1990 • 171 citations

STUDIES WITH TRITIUM-LABELLED HEXŒSTROL IN ADVANCED BREAST CANCER

1961 • 167 citations

Karnofsky memorial lecture. Conceptual and practical advances in the management of breast cancer.

1989 • 166 citations

Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival.

1991 • 166 citations

Mutations in the p53 gene in primary human breast cancers.

1991 • 165 citations

The immunocytochemical detection of axillary micrometastases in breast cancer

1984 • 157 citations

Correlation of Pretreatment Proliferative Activity of Breast Cancer With the Response to Cytotoxic Chemotherapy

1989 • 156 citations

correlation between histologic grade of malignancy and copy number of c-erbb-2 gene in breast carcinoma. A retrospective analysis of 176 cases

1990 • 152 citations

Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study

1990 • 150 citations

Relation between p53 overexpression and established prognostic factors in breast cancer.

1991 • 149 citations

Distribution of an estrogen-induced protein with a molecular weight of 24,000 in normal and malignant human tissues and cells.

1983 • 148 citations

Analysis of reproducibility of subjective grading systems for breast carcinoma.

1979 • 144 citations

Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.

1987 • 143 citations

Pathologic correlates of survival in 378 lymph node-negative infiltrating ductal breast carcinomas. Mitotic count is the best single predictor

1991 • 143 citations

SIGNIFICANCE OF INTERNAL MAMMARY LYMPH NODE METASTASES IN BREAST CANCER

1971 • 142 citations

P-Glycoprotein expression in treated and untreated human breast cancer

1989 • 133 citations

Varying Degrees of Malignancy in Cancer of the Breast

1925 • 131 citations

Haptoglobin-Related Protein (Hpr) Epitopes in Breast Cancer as a Predictor of Recurrence of the Disease

1989 • 129 citations

Significance of quantitative assessment of estrogen receptors for endocrine therapy in advanced breast cancer

1977 • 129 citations

Immunohistochemical analysis of P-glycoprotein expression correlated with chemotherapy resistance in locally advanced breast cancer

1990 • 127 citations

pS2 expression and response to hormonal therapy in patients with advanced breast cancer.

1991 • 123 citations

The prognostic significance of nuclear DNA content in invasive breast cancer – a study with long-term follow-up

1989 • 120 citations

Cathepsin D expression detected by immunohistochemistry has independent prognostic value in axillary node-negative breast cancer.

1993 • 118 citations

Predictive value of nuclear DNA content in breast cancer in relation to clinical and morphologic factors. A retrospective study of 227 consecutive cases

1988 • 117 citations

The 1982 national survey of carcinoma of the breast in the United States by the American College of Surgeons.

1984 • 115 citations

Quantitative estrogen receptor analyses: The response to endocrine and cytotoxic chemotherapy in human breast cancer and the disease-free interval

1980 • 111 citations

DNA index, S-phase fraction, histological grade and prognosis in breast cancer

1990 • 110 citations

The relation of flow cytometry to clinical and biologic characteristics in women with node negative primary breast cancer

1989 • 105 citations

Pathologic findings from the national surgical adjuvant breast project (protocol no. 4) vi. discriminants for five-year treatment failure

1980 • 105 citations

Pathologic findings from the national surgical adjuvant breast and bowel projects (NSABP) prognostic discriminants for 8-year survival for node-negative invasive breast cancer patients

1990 • 101 citations

Correlation of primary breast cancer histopathology and estrogen receptor content

1981 • 101 citations

Estrogen receptors in human breast cancer tissue

1972 • 100 citations

The morphometric prognostic index is the strongest prognosticator in premenopausal lymph node-negative and lymph node-positive breast cancer patients

1991 • 99 citations

THE ASSESSMENT OF HISTOLOGICAL DIFFERENTIATION IN BREAST CANCER*

1984 • 98 citations

DNA flow cytometric analysis of primary operable breast cancer. Relation of ploidy and S-Phase fraction to outcome of patients in NSABP B-04

1991 • 97 citations

The value of estrogen and progesterone receptor determinations in advanced breast cancer. Estrogen receptor level but not progesterone receptor level correlates with response to tamoxifen

1991 • 92 citations

Current status of Milan adjuvant chemotherapy trials for node-positive and node-negative breast cancer.

1986 • 87 citations

Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression or gene amplification.

1989 • 86 citations

Further Studies on Prognosis of Breast Carcinoma

1950 • 85 citations

Estrogen and progesterone receptors in cytology: A comprehensive review

1992 • 84 citations

Prognostic significance of flow cytometric DNA analysis in node-negative breast cancer patients

1990 • 84 citations

Practical breast carcinoma cell kinetics: Review and update

1984 • 82 citations

Prognostic significance of image morphometric microvessel enumeration in breast carcinoma.

1993 • 81 citations

Oestrogen Receptor in Human Breast Cancer Tissue and Response to Endocrine Therapy

1973 • 80 citations

Prognostic factors in recurrent breast cancer: relationships to site of recurrence, disease-free interval, female sex steroid receptors, ploidy and histological malignancy grading

1990 • 80 citations

Tritiated Thymidine Labeling Index and Response in Human Breast Cancer

1979 • 79 citations

Carcinoma of the breast.The prognostic significance of extranodal extension of axillary disease

1977 • 77 citations

p53 mutations and overexpression in locally advanced breast cancers

1994 • 74 citations

A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol

1993 • 74 citations

Predictability of Response to Endocrine Ablation in Advanced Breast Carcinoma

1973 • 73 citations

Factors predicting for response, time to treatment failure, and survival in women with metastatic breast cancer treated with DAVTH: a prospective Eastern Cooperative Oncology Group study.

1991 • 72 citations

DNA analysis by flow cytometry, response to endocrine treatment and prognosis in advanced carcinoma of the breast

1987 • 70 citations

Prognostic value of DNA ploidy and S-phase fraction in relation to estrogen receptor content and clinicopathological variables in primary breast cancer

1989 • 70 citations

Is DNA ploidy an independent prognostic indicator in infiltrative node-negative breast adenocarcinoma?

1990 • 66 citations

Flow cytometry in primary breast cancer: improving the prognostic value of the fraction of cells in the S-phase by optimal categorisation of cut-off levels

1990 • 62 citations

Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry. No correlation with survival at 5 years.

1992 • 61 citations

Elevated ras oncogene expression correlates with lymph node metastases in breast cancer patients.

1986 • 60 citations

Prognostic value of total cathepsin D in breast tumors

1991 • 55 citations

Cathepsin D concentration in breast cancer cytosols: correlation with biochemical, histological, and clinical findings

1991 • 54 citations

Effects of tamoxifen on estrogen and progesterone receptors in human breast cancer.

1981 • 53 citations

Use of monoclonal antibody for assessment of estrogen receptor content in fine-needle aspiration biopsy specimen from patients with breast cancer.

1989 • 51 citations

Prognostic and therapeutic significance of pathological features of breast cancer.

1986 • 50 citations

Correlations between certain biochemical properties of breast cancer and response to therapy: A preliminary report

1974 • 50 citations

Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers

1991 • 47 citations

Histological grade, elastosis, DNA ploidy and the response to chemotherapy of breast cancer

1987 • 44 citations

Improvement of the Quantification of Estrogen and Progesterone Receptors in Paraffin-Embedded Tumors by Image Analysis

1993 • 44 citations

Vascular Relationships of Tumor and Host*

2015 • 44 citations

Tumor factors predicting for prognosis in metastatic breast cancer: The presence of P24 predicts for response to treatment and duration of survival

1990 • 41 citations

The significance of supraclavicular fossa node recurrence after radical mastectomy

1986 • 40 citations

Relationships between oestrogen receptor, epidermal growth factor receptor, ER‐D5, and P24 oestrogen regulated protein in human breast cancer

1988 • 36 citations

Receptor and centriole pathways of steroid action in normal and neoplastic cells.

1978 • 35 citations

Bilateral adrenalectomy in metastatic mammary cancer:An analysis of sixty-four cases

1969 • 35 citations

Appearance and detection of multiple copies of the mdr‐1 gene in clinical samples of mammary carcinoma

1992 • 34 citations

Immunohistochemical Detection of Cathepsin D in T2N0M0 Breast Carcinoma

1994 • 31 citations

The prognostic significance of palpable lymph nodes in cancer of the breast

1969 • 31 citations

Immunohistochemical and other features of breast carcinomas presenting clinically compared with those detected by cancer screening

1991 • 29 citations

Immunocytochemical Analysis of Progesterone Receptors in Breast Cancer

1991 • 28 citations

Biological factors of prognostic significance in locally advanced breast cancer

1994 • 26 citations

Steroid-hormone receptors in nonpalpable and more advanced stages of breast cancer. A contribution to the biology and natural history of carcinoma of the female breast

1990 • 25 citations

Prognostic factors for recurrence and survival in axillary node-negative breast cancer

1989 • 25 citations

Evaluation of Rotter's lymph nodes in radical mastectomy specimens as a guide to prognosis

1965 • 23 citations

Specific protein synthesis regulated by estrogen in human breast cancer

1981 • 23 citations

Immunohistochemical localisation of pS2 protein in ductal carcinoma in situ and benign lesions of the breast

1993 • 22 citations

Immunocytochemical localization of estrogen and progesterone receptors in imprint preparations of breast carcinomas

1992 • 22 citations

Prognostic Factors in Node-Negative Breast Cancer

1992 • 20 citations

An observation of DNA ploidy, histological grade, and immunoreactivity for tumour‐related antigens in primary and metastatic breast carcinoma

1989 • 20 citations

Expression of Haptoglobin-related Protein in Primary and Metastatic Breast Cancers: A Longitudinal Study of 48 Fatal Tumors

1991 • 19 citations

Scalene node biopsy in locally advanced primary breast cancer of questionable operability

1964 • 18 citations

Prognostic Factors in Primary Breast Cancer

1986 • 18 citations

Response to second-line hormone treatment for advanced breast cancer. Predictive value of ploidy determination

1990 • 17 citations

Influence of S-phase fraction on metastatic pattern and post-recurrence survival in a randomized mammography screening trial

1989 • 15 citations

Use of monoclonal antibody for assessment of estrogen and progesterone receptors in malignant effusions

1992 • 14 citations

Interlaboratory Comparison of Estrogen Receptor Analysis in Paraffin Sections by a Monoclonal Antibody to Estrophilin (H222)

1993 • 14 citations

Tumor grade in the prognosis of breast cancer.

1970 • 14 citations

The significance of hyperemia around tumor implants.

1946 • 12 citations

Standardization of immunobioassays as surrogate endpoints.

1994 • 11 citations

Metastatic Pattern and DNA Ploidy in Stage IV Breast Cancer at Initial Diagnosis

1993 • 7 citations

Multidrug Resistance Phenotype: A Potential Marker of Chemotherapy Resistance in Breast Cancer?

1993 • 6 citations