Clinical Pharmacology of Antihypertensive Drugs in Children

Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg

1967 • 1,318 citations

Effects Morbidity of Treatment on in Hypertension

1970 • 1,278 citations

Effects of Treatment on Morbidity in Hypertension

1967 • 1,068 citations

Propranolol Inhibition of Renin Secretion

1972 • 729 citations

Hyperuricemia in Primary and Renal Hypertension

1966 • 506 citations

Treatment of hypertensive vascular disease with rice diet

1948 • 496 citations

Report of the task force on blood pressure control in children.

1977 • 431 citations

Role of blood pressure in cardiovascular morbidity and mortality

1974 • 418 citations

Uric acid nephrolithiasis

1968 • 324 citations

Late toxicity to hydralazine resembling systemic lupus erythematosus or rheumatoid arthritis

1973 • 322 citations

Treatment of Essential Hypertension with Combined Vasodilation and Beta-Adrenergic Blockade

1972 • 274 citations

Antihypertensive beta blocking action as related to renin and age: A pharmacologic tool to identify pathogenetic mechanisms in essential hypertension

1975 • 273 citations

The pharmacodynamics and metabolism of propranolol in man

1970 • 272 citations

Hemodynamic and Hypotensive Effects of Long-term Therapy with Chlorothiazide

1960 • 258 citations

Relationship of acetyl transferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine.

1970 • 257 citations

Propranolol in hypertension: A study of long-term therapy, 1964–1970

1972 • 218 citations

Long-Term Thiazide Therapy in Essential Hypertension

1970 • 215 citations

Combined Therapy with Vasodilator Drugs and Beta-Adrenergic Blockade in Hypertension

1972 • 200 citations

Relationship Between Plasma and Extracellular Fluid Volume Depletion and the Antihypertensive Effect of Chlorothiazide

1959 • 184 citations

Adverse reactions to propranolol in hospitalized medical patients: A report from the Boston Collaborative Drug Surveillance Program

1973 • 182 citations

Proposed Mechanisms of Propranolol's Antihypertensive Effect in Essential Hypertension

1976 • 179 citations

The central action of antihypertensive drugs, mediated via central α -receptors

1973 • 170 citations

Absorption, metabolism, and excretion of hydrochlorothiazide

1976 • 167 citations

Dependence of Arterial Pressure on Intravascular Volume in Treated Hypertensive Patients

1972 • 161 citations

Propranolol

1975 • 159 citations

Relation of hydralazine plasma concentration to dosage and hypotensive action

1972 • 153 citations

High blood pressure, other risk factors and longevity: The insurance viewpoint

1973 • 141 citations

A review of the animal pharmacology of labetalol, a combined alpha- and beta-adrenoceptor-blocking drug.

1976 • 138 citations

Immune Responses to Hydralazine and Nuclear Antigens in Hydralazine-Induced Lupus Erythematosus

1972 • 135 citations

The Value of Aggressive Therapy in the Hypertensive Patient with Azotemia

1969 • 133 citations

Hydralazine elimination in man

1973 • 133 citations

Effects of Clonidine Withdrawal: Possible Mechanisms and Suggestions for Management

1973 • 132 citations

Brain concentration of propranolol in relation to hypotensive effect in the rabbit with observations on brain propranolol levels in man.

1975 • 132 citations

Effect of Thiazides on Carbohydrate Metabolism in Patients with Hypertension

1961 • 127 citations

DIETARY TREATMENT OF HYPERTENSION. CLINICAL AND METABOLIC STUDIES OF PATIENTS ON THE RICE-FRUIT DIET

1950 • 126 citations

CENTRAL α‐ AND β‐ADRENOCEPTORS MODIFYING ARTERIAL BLOOD PRESSURE AND HEART RATE IN CONSCIOUS CATS

1974 • 119 citations

CARDIOVASCULAR AND RENAL ADJUSTMENTS TO A HYPOTENSIVE AGENT

1952 • 117 citations

β-Adrenergic Blockade in Diuretic-Treated Patients with Essential Hypertension

1975 • 116 citations

Clonidine, a New Antihypertensive Drug

1975 • 115 citations

Pharmacokinetics of oral propranolol in chronic renal disease

1974 • 113 citations

Changes in Plasma and Extracellular Fluid Volumes in Patients with Essential Hypertension During Long-Term Treatment with Hydrochlorothiazide

1970 • 111 citations

Disposition of propranolol VI. Independent variation in steady‐state circulating drug concentrations and half‐life as a result of plasma drug binding in man

1973 • 110 citations

Recent Advances in Renal Physiology and Pharmacology

1975 • 109 citations

Thiazide-Induced Hypercalcemia

1971 • 108 citations

Pharmacokinetics of orally administered furosemide

1974 • 108 citations

Methyldopa hepatitis

1976 • 106 citations

Partial Reduction of Blood Pressure and Prevention of Complications in Hypertension

1974 • 104 citations

Assessment of alpha‐ and beta‐adrenoceptor blocking actions of labetalol.

1976 • 104 citations

Pharmacokinetics of furosemide in normal subjects and functionally anephric patients

1974 • 100 citations

Pharmacokinetic studies of minoxidil

1972 • 95 citations

ASSESSMENT OF CADAVERIC KIDNEYS FOR TRANSPLANTATION

1975 • 94 citations

A Comparison of the Effects of Hydrochlorothiazide and of Frusemide in the Treatment of Hypertensive Patients

1971 • 93 citations

Analysis of the hypotensive action of prazosin.

1975 • 91 citations

ONE SWITCH TOO MANY

1964 • 90 citations

Influence of extracellular fluid volume on response to antihypertensive drugs.

1970 • 89 citations

Pharmacokinetics of furosemide in advanced renal failure

1974 • 87 citations

The Antihypertensive Actions of Benzothiadiazines

1961 • 83 citations

SALT INTAKE AND EATING PATTERNS OF INFANTS AND CHILDREN IN RELATION TO BLOOD PRESSURE

1974 • 81 citations

Depressive Reactions in Hypertensive Patients

1959 • 76 citations

Duration of hydralazine action in hypertension

1975 • 76 citations

Pharmacokinetics of methyldopa in man.

1976 • 74 citations

Hypertension in children and adolescents. I. Causes and diagnostic studies

1969 • 71 citations

The mechanism of the antihypertensive action of α-methyldopa in hypertensive rats

1973 • 69 citations

THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS.

1964 • 68 citations

Juvenile hypertension

1978 • 63 citations

Minoxidil therapy in children with severe hypertension

1977 • 63 citations

Individualization of Propranolol Therapy

1974 • 59 citations

PROPRANOLOL GIVEN TWICE DAILY IN HYPERTENSION

1973 • 57 citations

Relationship of extracellular fluid volume to the development of drug resistance in the hypertensive patient

1971 • 53 citations

Gynecomastia and Impotence Complications of Spironolactone Therapy

1973 • 52 citations

SODIUM RESTRICTION AND THIAZIDE DIURETICS IN THE TREATMENT OF HYPERTENSION

1975 • 52 citations

Toxicity of ethacrynic acid and furosemide

1973 • 52 citations

Frusemide-induced pancreatitis.

1975 • 51 citations

EVALUATION OF BETA BLOCKADE, BENDROFLUAZIDE, AND PRAZOSIN IN SEVERE HYPERTENSION

1977 • 50 citations

Anticonvulsant-induced antinuclear antibodiesand lupus-like disease in children

1973 • 49 citations

The effects of alpha-methyldopa on renal function in hypertensive patients

1968 • 49 citations

RAUWOLFIA DERIVATIVES AND BREAST CANCER IN HYPERTENSIVE WOMEN

1976 • 49 citations

Long-Term Effects of Furosemide and Hydrochlorothiazide in Patients With Essential Hypertension

1977 • 48 citations

Treatment of Low-Renin Essential Hypertension

1974 • 45 citations

Hypertension: Mechanisms and management

1982 • 44 citations

Low-Renin Hypertension

1974 • 43 citations

Prolonged treatment with clonidine: Comparative antihypertensive effects alone and with a diuretic agent

1972 • 42 citations

Potassium-sparing Agents during Diuretic Therapy in Hypertension

1971 • 41 citations

Clinical toxicity of reserpine in hospitalized patients: a report from the Boston Collaborative Drug Surveillance Program

1976 • 40 citations

Management of severe childhood hypertension with minoxidil: A controlled clinical study

1977 • 38 citations

Some observations on the pharmacology of hydrochlorothiazide

1959 • 37 citations

CENTRAL ADRENORECEPTORS AND THE CONTROL OF ARTERIAL BLOOD PRESSURE

1974 • 36 citations

High pressure liquid chromatography in clinical chemistry

1977 • 33 citations

EXPERIENCE WITH PRAZOSIN IN THE TREATMENT OF PATIENTS WITH SEVERE HYPERTENSION

1962 • 32 citations

Immunologic findings in patients receiving methyldopa: a prospective study.

1971 • 32 citations

Effects of large and small doses of hydrochlorothiazide in hypertensive patients

1970 • 31 citations

Spironolactone and hydrochlorothiazide in normal‐renin and low‐renin essential hypertension

1977 • 29 citations

Diuretic-Induced Interstitial Nephritis

1976 • 29 citations

Central inhibitory effect of α-methyldopa on blood pressure, heart rate and body temperature of renal hypertensive rats

1975 • 29 citations

OTOTOXICITY OF INTRAVENOUS FRUSEMIDE

1971 • 28 citations

Adverse reactions to beta-blocking drugs: a review.

1976 • 28 citations

Bioavailability of potassium from a slow‐release tablet

1973 • 28 citations

The effect of dosage regimen on the diuretic efficacy of chlorothiazide in human subjects.

1961 • 27 citations

Prazosin in hypertension: a double-blind evaluation with methyldopa and placebo.

1974 • 26 citations

Hydralazine-Induced Lupus Erythematosus-Like Syndrome

1975 • 24 citations

Minoxidil in refractory hypertension

1975 • 23 citations

Effect of methyldopa, reserpine and guanethidine on hindleg vascular resistance.

1968 • 22 citations

Large dose furosemide therapy for hypertension

1974 • 22 citations

Effect of dosage regimen on natriuretic response to furosemide

1975 • 22 citations

Treatment of high-renin hypertension with propranolol in children after renal transplantation

1977 • 21 citations

A loading-maintenance regimen for more rapid initiation of the effect of guanethidine

1975 • 21 citations

Vasodilation for Vasospastic Hypertension

1973 • 20 citations

Hydralazine therapy in hypertensive patients with idiopathic systemic lupus erythematosus

1975 • 19 citations

Effect of Treatment on Longevity in Spontaneously Hypertensive Rats

1975 • 18 citations

Colitis and Hepatitis Caused by Methyldopa

1976 • 18 citations

Clinical evaluation of prazosin as the sole agent for the treatment of hypertension: a double-blind cross-over study with methyldopa.

1975 • 17 citations

Clonidine Poisoning

1976 • 17 citations

GASTRIC SECRETION AS INFLUENCED BY RAUWOLFIA ALKALOIDS

1957 • 16 citations

BENEFIT—RISK FACTORS ASSOCIATED WITH SUPPLEMENTAL POTASSIUM THERAPY

1976 • 16 citations

Altered Vascular Responsiveness: Initial Hypotensive Mechanism of Thiazide Diuretics

1972 • 16 citations

Furosemide in Essential Hypertension

1971 • 15 citations

Use and abuse of diuretics

1975 • 13 citations

Diuretic effect of furosemide in acute glomerulonephritis

1976 • 12 citations

Hypertension and Seizures Following Methyldopa Infusion

1967 • 12 citations

Similar effects of hydrochlorothiazide and spironolactone on plasma renin activity in essential hypertension

1972 • 10 citations

Interference in the Measurement of Plasma 11-Hydroxycorticosteroids Caused by Spironolactone Administration

1970 • 10 citations

TREATMENT OF SEVERE HYPERTENSION WITH CATAPRES® (St 155)

1971 • 8 citations

RESERPINE-INDUCED GASTROINTESTINAL HEMORRHAGE

1959 • 8 citations

HYDROCHLOROTHIAZIDE (HCT) THERAPY IN HYPERTENSIVE (HT) AND RENAL INSUFFICIENT (RI) CHILDREN: ELIMINATION KINETICS AND METABOLIC EFFECTS

1977 • 7 citations

Unusual complication of high-dose frusemide.

1975 • 7 citations

The Origins and Evils of Essential Hypertension

1971 • 7 citations

Peripheral Vascular Actions of -Methyl-DOPA and Its Mode of Action on Arterioles

1974 • 6 citations

Methyldopa in the management of hypertension

1972 • 5 citations

The Effect of Triamterene on Plasma and Extracellular Fluid Volume and Blood Pressure in Ten Thiazide-Treated Hypokalemic Patients with Essential Hypertension

1972 • 3 citations