Autoantibodies Against Nuclear, Nucleolar, and Mitochondrial Antigens in Systemic Sclerosis (Scleroderma)

Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)

1972 • 1,816 citations

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus

1979 • 1,178 citations

Autoantibody to centromere (kinetochore) in scleroderma sera.

1980 • 721 citations

Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis

1988 • 568 citations

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis.

1987 • 557 citations

Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus

2001 • 551 citations

Diversity of antinuclear antibodies in progressive systemic sclerosis

1980 • 520 citations

Fibrillarin: a new protein of the nucleolus identified by autoimmune sera

1985 • 488 citations

SnRNAs, SnRNPs, and RNA Processing

1982 • 458 citations

Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus

1966 • 452 citations

Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen

1987 • 420 citations

The CREST syndrome: A distinct serologic entity with anticentromere antibodies

1980 • 369 citations

Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein

1983 • 333 citations

Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry.

1984 • 313 citations

Kinetochore structure, duplication, and distribution in mammalian cells: analysis by human autoantibodies from scleroderma patients.

1981 • 312 citations

High Titers of Autoantibodies to Topoisomerase I (Scl-70) in Sera from Scleroderma Patients

1986 • 307 citations

Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.

1985 • 282 citations

VARIATIONS IN THE MORPHOLOGICAL PATTERNS OF "AUTOIMMUNE" NUCLEAR FLUORESCENCE

1961 • 281 citations

Identification of a nuclear protein (Scl-70) as a unique target of human antinuclear antibodies in scleroderma.

1979 • 279 citations

Monoclonal autoantibody from a (new zealand black x new zealand white)F₁ mouse and some human scleroderma sera target an MT_r 34,000 nucleolar protein of the U3 RNP particle

1987 • 252 citations

Autoantibody to RNA polymerase I in scleroderma sera.

1987 • 241 citations

Differentiation of antinuclear antibodies giving speckled staining patterns in immunofluorescence

1972 • 238 citations

Clinical and laboratory associations of anticentromere antibody in patients with progressive systemic sclerosis

1984 • 232 citations

Clinical associations of anticentromere antibodies and antibodies to topoisomerase i. a study of 355 patients

1988 • 223 citations

Primary biliary cirrhosis with scleroderma, Raynaud's phenomenon and telangiectasia

1971 • 221 citations

Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma)

1988 • 213 citations

Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies.

1986 • 206 citations

Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis.

1982 • 201 citations

Different antibody patterns and different prognoses in patients with scleroderma with various extent of skin sclerosis.

1986 • 196 citations

Structural analysis of the human U3 ribonucleoprotein particle reveal a conserved sequence available for base pairing with pre-rRNA.

1987 • 190 citations

Antibodies to a nuclear/nucleolar antigen in patients with polymyositis overlap syndromes

1984 • 184 citations

Detection of a nucleolar 7-2 ribonucleoprotein and a cytoplasmic 8-2 ribonucleoprotein with autoantibodies from patients with scleroderma.

1983 • 177 citations

Serological markers in progressive systemic sclerosis: clinical correlations.

1983 • 176 citations

Scleroderma and Primary Biliary Cirrhosis

1970 • 147 citations

Distribution of kinetochore (centromere) antigen in mammalian cell nuclei.

1981 • 147 citations

Serum antinuclear antibodies in progressive systemic sclerosis (scleroderma)

1968 • 143 citations

Anticentromere and Anticentriole Antibodies in the Scleroderma Spectrum

1983 • 133 citations

Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I

1986 • 133 citations

Human autoantibodies: probes for nucleolus structure and function

1987 • 128 citations

Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/scleroderma overlap syndromes.

1986 • 124 citations

Human anticentromere antibodies: Distribution, characterization of antigens, and effect on microtubule organization

1983 • 120 citations

Molecular characterization of ribonucleoprotein antigens bound by antinuclear antibodies. A diagnostic evaluation

1982 • 117 citations

Sequential association of nucleolar 7-2 RNA with two different autoantigens.

1983 • 117 citations

Enzymes of Nucleic Acid Synthesis and Modification

2018 • 116 citations

Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice.

1989 • 114 citations

Antibodies against distinct nuclear matrix proteins are characteristic for mixed connective tissue disease.

1983 • 114 citations

Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription

1988 • 113 citations

Immunolocalization of 7-2-ribonucleoprotein in the granular component of the nucleolus

1988 • 111 citations

Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud's phenomenon.

1982 • 111 citations

Inhibition of nucleolar reformation after microinjection of antibodies to RNA polymerase I into mitotic cells.

1987 • 110 citations

Antinuclear antibodies in patients with Raynaud's phenomenon: clinical significance of anticentromere antibodies.

1982 • 110 citations

Topoisomerase I identified by scleroderma 70 antisera: enrichment of topoisomerase I at the centromere in mouse mitotic cells before anaphase.

1986 • 108 citations

Anticentromere antibody

1983 • 104 citations

Evolution of primary raynaud's phenomenon (raynaud's disease) to connective tissue disease

1985 • 103 citations

Anti-NOR 90. A new autoantibody in scleroderma that recognizes a 90-kDa component of the nucleolus-organizing region of chromatin.

1987 • 94 citations

Human anti-centromere sera recognise a 19.5 kD non-histone chromosomal protein from HeLa cells.

1984 • 94 citations

A long‐term longitudinal study of anticentromere antibodies

1984 • 90 citations

ANTINUCLEAR AND PRECIPITATING AUTOANTIBODIES IN PROGRESSIVE SYSTEMIC SCLEROSIS

1963 • 89 citations

Scl 70 antibody—a specific marker of systemic sclerosis

1986 • 87 citations

Scl-86, a marker antigen for diffuse scleroderma.

1985 • 85 citations

Ribonucleoprotein antibodies: frequency and clinical significance in systemic lupus erythematosus, scleroderma, and mixed connective tissue disease.

1973 • 80 citations

Antinucleolar Antibodies in Human Sera

1973 • 76 citations

Protein antigens of the RNA-protein complexes detected by anti-SM and anti-RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders.

1982 • 74 citations

Antinuclear Antibodies. I. Patterns of Nuclear Immunofluorescence

1974 • 73 citations

Antinucleolar Antibodies

1970 • 71 citations

Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease.

1982 • 70 citations

The Immunofluorescent Tumor Imprint Technique

1966 • 69 citations

Murine lupus monoclonal antibodies define five epitopes on two different Sm polypeptides.

1986 • 61 citations

Nucleolar localization of the PM‐Scl antigen

1985 • 56 citations

Speckled pattern antinuclear antibodies resembling anticentromere antibodies

1984 • 53 citations

The PBC-specific antigen

1985 • 52 citations

Autoantibodies to mitochondria in systemic sclerosis. frequency and characterization using recombinant cloned autoantigen

1988 • 44 citations

Nucleolar changes after microinjection of antibodies to RNA polymerase I into the nucleus of mammalian cells

1988 • 41 citations

Human anticentriole autoantibody in patients with scleroderma and Raynaud's phenomenon

1983 • 41 citations

Identification and characterization of mitochondria autoantigens in progressive systemic sclerosis: identity with the 72,000 dalton autoantigen in primary biliary cirrhosis.

1986 • 36 citations

Variability of tissue-localizing properties of serum from patients with different disease states.

1962 • 35 citations

Polypeptide components of human small nuclear ribonucleoproteins.

1983 • 35 citations

Precipitating autoantibodies to mitochondrial proteins in progressive systemic sclerosis.

1984 • 34 citations

Anticentromere antibody: an immunological marker of a subset of systemic sclerosis

1985 • 34 citations

High prevalence of anti-mitochondrial antibodies among patients with some well-defined connective tissue diseases.

1986 • 30 citations

Antinuclear Antibodies as Immunologic Markers for a Benign Subset and Different Clinical Characteristics of Scleroderma

1982 • 29 citations

Immunofluorescence studies in progressive systemic sclerosis (scleroderma) and mixed connective tissue disease

1983 • 28 citations

Autoantibodies to nonhistone nuclear antigens and their clinical significance

1983 • 24 citations

Clinical association of autoantibodies to fibrillarin with diffuse scleroderma and disseminated telangiectasia

1990 • 23 citations

Scl-95/100: doublet of endothelial marker autoantigens in progressive systemic sclerosis.

1986 • 23 citations

Anticentriole antibody in a patient with progressive systemic sclerosis

1986 • 16 citations

Intracellular Autoantigens: Diagnostic Fingerprints but Aetiological Dilemmas

2007 • 9 citations

CIBA Foundation Symposium 129: Autoimmunity and Autoimmune Disease

1988 • 2 citations

Characterization of Nucleolar 7-2 RNP Recognized by Sera from Patients with Autoimmune Diseases

1989 • 1 citations

The TH Ribonucleoprotein Particle: Identity with RNase MRP and Association with RNase P

1989 • 1 citations