Inactivation of human gamma interferon by Pseudomonas aeruginosa proteases: elastase augments the effects of alkaline protease despite the presence of alpha 2-macroglobulin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The interaction of α2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

1973 • 1,062 citations

The electrophoretically ‘slow’ and ‘fast’ forms of the α2-macroglobulin molecule

1979 • 530 citations

A new ultrasensitive method for the determination of proteolytic activity

1968 • 365 citations

STUDIES ON HUMAN PLASMA α2-MACROGLOBULIN-ENZYME INTERACTIONS

1973 • 362 citations

[54] α2-Macroglobulin

1981 • 316 citations

Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.

1986 • 198 citations

Macroglobulin from Human Plasma Which Forms an Enzymatically Active Compound with Trypsin

1964 • 166 citations

Functional modifications of alpha 2-macroglobulin by primary amines. I. Characterization of alpha 2 M after derivatization by methylamine and by factor XIII.

1981 • 152 citations

Evidence for similar conformational changes in α2-macroglobulin on reaction with primary amines or proteolytic enzymes

1982 • 120 citations

Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: extracellular protease and elastase as in vivo virulence factors

1979 • 96 citations

Pseudomonas aeruginosa alkaline protease degrades human gamma interferon and inhibits its bioactivity

1988 • 95 citations

Pancreatic elastase in human serum. Determination by radioimmunoassay.

1977 • 88 citations

Production of protease and elastase by Pseudomonas aeruginosa strains isolated from patients

1977 • 87 citations

A monoclonal antibody to a neo-antigen on alpha 2-macroglobulin complexes inhibits receptor-mediated endocytosis.

1981 • 83 citations

Inhibition of human lymphocyte proliferation and cleavage of interleukin-2 by Pseudomonas aeruginosa proteases

1988 • 76 citations

Increased susceptibility to lethal Candida infections in burned mice preinfected with Pseudomonas aeruginosa or pretreated with proteolytic enzymes

1986 • 73 citations

Molecular alteration of α2-macroglobulin by aliphatic amines

1968 • 71 citations

In vitro inhibition of lymphocyte proliferation by Pseudomonas aeruginosa phenazine pigments

1983 • 69 citations

Studies on the mechanism of T cell inhibition by the Pseudomonas aeruginosa phenazine pigment pyocyanine.

1987 • 54 citations

Protease phenotypes of Pseudomonas aeruginosa isolated from patients with cystic fibrosis

1983 • 47 citations

Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients

1977 • 46 citations

Inactivation of human interleukin-2 (IL-2) by alpha 2-macroglobulin-trypsin complexes.

1986 • 42 citations

Proinsulin conversion to desalanyl insulin by α2-macroglobin-bound trypsin

1977 • 37 citations

Defective cellular immunity to gram-negative bacteria in cystic fibrosis patients

1979 • 37 citations

Phosphoramidon as an inhibitor of elastase from Pseudomonas aeruginosa.

1978 • 27 citations

Reaction of methylamine with human alpha 2-macroglobulin. Mechanism of inactivation.

1985 • 26 citations

Depression by Pseudomonas aeruginosa of Two T-Cell-Mediated Responses, Anti- Listeria Immunity and Delayed- Type Hypersensitivity to Sheep Erythrocytes

1982 • 25 citations

Variables which affect suppression of the immune response induced by Pseudomonas aeruginosa exotoxin A

1986 • 23 citations

Identification of the principal T lymphocyte-stimulating antigens of Pseudomonas aeruginosa.

1984 • 22 citations

Correlation of proteolytic activity of Pseudomonas aeruginosa with site of isolation

1980 • 21 citations

Experimental Studies of the Pathogenesis of Infections Due to Pseudomonas aeruginosa: Effect of Treatment with Protease Inhibitors

1983 • 21 citations

[77] A sandwich radioimmunoassay for human IFN-γ

1986 • 19 citations

Antigenic specificities of Pseudomonas aeruginosa alkaline protease and elastase defined by human T cell clones.

1986 • 15 citations

Suppression of the delayed-type hypersensitivity and cell-mediated immune responses to Listeria monocytogenes induced by Pseudomonas aeruginosa

1987 • 10 citations

The antigenicity of a pulmonary pathogen defined by monoclonal T cells.

1987 • 4 citations