Results of single-agent and combination chemotherapy for advanced soft tissue sarcomas. Implications for decision making in the clinic.

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Cancer statistics, 1994

1994 • 1,345 citations

The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts

1994 • 1,069 citations

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

1992 • 730 citations

Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Chemotherapy-Induced Myelosuppression

1988 • 689 citations

Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas.

1993 • 504 citations

An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas.

1993 • 473 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

American Society of Clinical Oncology. Recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines.

1994 • 438 citations

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.

1990 • 407 citations

Dose response evaluation of adriamycin in human neoplasia

1977 • 389 citations

A randomized clinical trial of adjuvant adriamycin in uterine sarcomas: a Gynecologic Oncology Group Study.

1985 • 387 citations

A randomized trial of two dose levels of cyclophosphamide, methotrexate, and fluorouracil chemotherapy for patients with metastatic breast cancer.

1988 • 354 citations

A randomized study of adriamycin with and without dimethyl triazenoimidazole carboxamide in advanced uterine sarcomas

1983 • 352 citations

Diagnostic Relevance of Clonal Cytogenetic Aberrations in Malignant Soft-Tissue Tumors

1991 • 322 citations

Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas.

1987 • 284 citations

Response to mesna, doxorubicin, ifosfamide, and dacarbazine in 108 patients with metastatic or unresectable sarcoma and no prior chemotherapy.

1989 • 273 citations

IMVP-16: an effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy

1982 • 272 citations

The use of granulocyte colony-stimulating factor to increase the intensity of treatment with doxorubicin in patients with advanced breast and ovarian cancer

1989 • 267 citations

Adjuvant CYVADIC chemotherapy for adult soft tissue sarcoma--reduced local recurrence but no improvement in survival: a study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group.

1994 • 245 citations

Cyclophosphamide versus ifosfamide: Final report of a randomized phase II trial in adult soft tissue sarcomas

1987 • 244 citations

Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma.

1989 • 242 citations

Altered Expression of the Retinoblastoma Gene Product in Human Sarcomas

1990 • 221 citations

Malignant peripheral neuroectodermal tumors.A retrospective analysis of 42 patients

1988 • 220 citations

Myeloablative radiochemotherapy and hematopoietic stem-cell rescue in poor-prognosis Ewing's sarcoma.

1993 • 220 citations

Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities

1983 • 210 citations

Treatment of recurrent or advanced uterine sarcoma. A randomized trial of doxorubicinVersus doxorubicin and cyclophosphamide (a phase III trial of the gynecologic oncology group)

1985 • 203 citations

Adjuvant chemotherapy for patients with high-grade soft-tissue sarcomas of the extremity.

1988 • 177 citations

A comparison of adriamycin versus vincristine and adriamycin, and cyclophosphamide versus vincristine, actinomycin-D, and cyclophosphamide for advanced sarcoma

1982 • 170 citations

Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: a phase II study.

1990 • 161 citations

A prospective randomized trial of adjuvant chemotherapy with bolus versus continuous infusion of doxorubicin in patients with high-grade extremity soft tissue sarcoma and an analysis of prognostic factors

1991 • 160 citations

Adjuvant chemotherapy with doxorubicin in high-grade soft tissue sarcoma: a randomized trial of the Scandinavian Sarcoma Group.

1989 • 154 citations

Granulocyte-macrophage colony-stimulating factor allows safe escalation of dose-intensity of chemotherapy in metastatic adult soft tissue sarcomas: a study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group.

1993 • 152 citations

High-dose ifosfamide with mesna uroprotection: a phase I study.

1990 • 144 citations

A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk

1985 • 139 citations

Cyvadic in advanced soft tissue sarcoma: A randomized study comparing two schedules: A study of the EORTC soft tissue and bone sarcoma group

1984 • 128 citations

A randomized trial for the treatment of high-grade soft-tissue sarcomas of the extremities: preliminary observations.

1986 • 128 citations

Treatment of peripheral neuroepithelioma in children and young adults.

1987 • 120 citations

Randomized study of systemic chemotherapy following complete excision of nonosseous sarcomas.

1984 • 104 citations

Combination chemotherapy using adriamycin, DTIC, cyclophosphamide, and actinomycin D for advanced soft tissue sarcomas: a randomized comparative trial. A phase III, Southwest Oncology Group Study (7613).

1987 • 95 citations

Ifosfamide plus doxorubicin in previously untreated patients with advanced soft tissue sarcoma

1990 • 86 citations

Preliminary results of a randomized trial of adjuvant doxorubicin for sarcomas: lack of apparent difference between treatment groups.

1984 • 85 citations

Goals of palliative cancer therapy.

1993 • 80 citations

Randomized comparison of doxorubicin and vindesine to doxorubicin for patients with metastatic soft-tissue sarcomas

1990 • 79 citations

Prospective evaluation of doxorubicin-induced cardiomyopathy resulting from postsurgical adjuvant treatment of patients with soft tissue sarcomas

2006 • 68 citations

Ifosfamide plus doxorubicin in metastatic adult sarcomas: a multi-institutional phase II trial.

1989 • 65 citations

Protected environment–Prophylactic antibiotic program for malignant sarcomas: Randomized trial during remission induction chemotherapy

1981 • 57 citations

Phase I clinical trial of carboplatin and 41.8 degrees C whole-body hyperthermia in cancer patients.

1993 • 55 citations

Effects of PIXY321, a granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein, on chemotherapy-induced multilineage myelosuppression in patients with sarcoma.

1994 • 55 citations

The N-domain of the biliary glycoprotein (BGP) adhesion molecule mediates homotypic binding: domain interactions and epitope analysis of BGPc

1994 • 52 citations

CHEMOTHERAPY OF SARCOMA

1978 • 44 citations

A phase I–II study of ifosfamide in combination with adriamycin in the treatment of adult soft tissue sarcoma

1988 • 40 citations

Combination Chemotherapy With Doxorubicin, Dacarbazine, and Ifosfamide in Advanced Adult Soft Tissue Sarcoma

1989 • 33 citations

A phase II study of ifosfamide/mesna with doxorubicin for adult soft tissue sarcoma

1988 • 24 citations

Phase II Trial of Carboplatin in Soft-Tissue Sarcoma

1990 • 22 citations

Hematopoietic growth factors: Current knowledge, future prospects

1992 • 21 citations

Alternatives to CYVADIC combination therapy of soft tissue sarcomas

1986 • 20 citations

Increased expression of the multidrug-resistance gene in undifferentiated sarcoma

1990 • 18 citations

High-dose cisplatin for metastatic soft tissue sarcoma

1990 • 14 citations

Epirubicin and DTIC (EDIC) for Advanced Soft-Tissue Sarcomas

1991 • 12 citations

The Use of Hematopoietic Growth Factors to Support Cytotoxic Chemotherapy for Patients with Breast Cancer

1994 • 7 citations

Treatment of advanced soft tissue sarcomas with ifosfamide (IFF) and adriamycin (ADM)

1986 • 6 citations