Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

1988 • 845 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment

1987 • 636 citations

Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro

1995 • 505 citations

The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma.

1986 • 492 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Circulating Activated Suppressor T Lymphocytes in Aplastic Anemia

1985 • 349 citations

Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo.

1985 • 343 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer

1991 • 292 citations

Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus.

1992 • 243 citations

Interferon‐γ and tumor necrosis factor‐α suppress both early and late stages of hematopoiesis and induce programmed cell death

1995 • 232 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta

1990 • 227 citations

Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver.

1994 • 217 citations

Studies of interferon as a regulator of hematopoietic cell proliferation.

1985 • 195 citations

The treatment of severe acquired aplastic anemia

1995 • 190 citations

Involvement of interferon‐γ and macrophage colony‐stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults

1994 • 169 citations

Increased transforming growth factor‐β, interleukin‐4, and interferon‐γ in multiple sclerosis

1994 • 162 citations

Tumor necrosis factor-alpha and hematopoietic progenitors: effects of tumor necrosis factor on the growth of erythroid progenitors CFU-E and BFU-E and the hematopoietic cell lines K562, HL60, and HEL cells.

1987 • 155 citations

Measurement of serum cytokine levels in patients with myelodysplastic syndromes.

1992 • 150 citations

Gamma-Interferon Gene Expression in the Bone Marrow of Patients with Aplastic Anemia

1994 • 133 citations

Interleukin-1, tumor necrosis factor, and the production of colony- stimulating factors by cultured mesenchymal cells

1988 • 125 citations

The hematopoietic microenvironment

1991 • 121 citations

Phenotypic and functional analysis of bone marrow progenitor cell compartment in bone marrow failure

1994 • 113 citations

Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure.

1994 • 108 citations

In vitro assessment of marrow ‘stem cell’and stromal cell function in aplastic anaemia

1991 • 107 citations

Identification of the lymphokines, interferon-gamma and interleukin-2, in inflammatory eye diseases.

1988 • 105 citations

An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures

1994 • 88 citations

Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1

1988 • 79 citations

Interferon-gamma gene expression in unstimulated bone marrow mononuclear cells predicts a good response to cyclosporine therapy in aplastic anemia

1992 • 77 citations

Interferon-gamma enhances factor-dependent myeloid proliferation of human CD34+ hematopoietic progenitor cells

1992 • 69 citations

Functionally abnormal marrow stromal cells in aplastic anemia.

1985 • 68 citations

Interferon gamma selectively inhibits very primitive CD342+CD38- and not more mature CD34+CD38+ human hematopoietic progenitor cells.

1994 • 67 citations

Aplastic anemia: analysis of stromal cell function in long-term marrow cultures

1994 • 62 citations

Functional Changes in Marrow Stromal Cells in Aplastic Anaemia

1985 • 60 citations

Synergistic effect of recombinant interferon-gamma and interleukin-3 on the growth of immature human hematopoietic progenitors

1991 • 58 citations

Type-I Diabetes: A Chronic Autoimmune Disease Of Human, Mouse, And Rat

1990 • 47 citations

Acute hematologic effects of interferon alpha, interferon gamma, tumor necrosis factor alpha and Interleukin 2

1991 • 44 citations

Analysis at the clonal level of T-cell phenotype and functions in severe aplastic anemia patients

1991 • 43 citations

Gamma-interferon in aplastic anemia: inability to detect significant levels in sera or demonstrate hematopoietic suppressing activity

1987 • 40 citations

Long-term marrow culture in patients with aplastic anemia compared with marrow transplant recipients and normal controls.

1992 • 39 citations

Intermittent interferonemia and interferon responses in multiple sclerosis

1991 • 32 citations

The biology of long-term bone marrow cultures and its application to bone marrow transplantation

1991 • 25 citations

Interferon and autoimmunity.

1983 • 24 citations

Expression of stem cell inhibitor (SCI) gene in patients with bone marrow failure.

1992 • 19 citations

Studies on the regulation of hemopoiesis.

1985 • 17 citations

Different haematopoietic growth factors have different capacity in overcoming the in vitro interferon gamma-induced suppression of bone marrow progenitor cells

1990 • 16 citations

Colony stimulating activity in normal human serum tested against human bone marrow.

1980 • 15 citations

An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures

1994 • 6 citations

Interferon-gamma enhances factor-dependent myeloid proliferation of human CD34+ hematopoietic progenitor cells

1992 • 6 citations

Synergistic effect of recombinant interferon-gamma and interleukin-3 on the growth of immature human hematopoietic progenitors

1991 • 3 citations

Gamma-interferon in aplastic anemia: inability to detect significant levels in sera or demonstrate hematopoietic suppressing activity

1987 • 3 citations

Analysis at the clonal level of T-cell phenotype and functions in severe aplastic anemia patients

1991 • 1 citations