Megakaryocytic maturation in murine long-term bone marrow culture: role of interleukin-6

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

The biology of interleukin-6

1989 • 1,964 citations

[1] Preparation of monoclonal antibodies: Strategies and procedures

1981 • 1,787 citations

Monoclonal Antibodies: Principles and Practice

1996 • 928 citations

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1987 • 847 citations

Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.

1989 • 470 citations

Functional discrimination between interleukin 6 and interleukin 1

1988 • 443 citations

Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro.

1989 • 430 citations

Interleukin-6 is a potent thrombopoietic factor in vivo in mice

1989 • 422 citations

Regulation of megakaryocytopoiesis

1989 • 305 citations

Cholinesterase as a Possible Marker for Early Cells of the Megakaryocytic Series

1973 • 297 citations

Enzymatic treatment of long-term human marrow cultures reveals the preferential location of primitive hemopoietic progenitors in the adherent layer

1983 • 296 citations

In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets

1990 • 280 citations

Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice

1990 • 226 citations

Human recombinant erythropoietin promotes differentiation of murine megakaryocytes in vitro.

1987 • 191 citations

Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.

1988 • 174 citations

Human interleukin-6 supports granulocytic differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSF

1989 • 157 citations

Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic, erythroid, myeloid, and multipotential progenitor cells

1989 • 156 citations

Stimulation of thrombopoiesis in mice by human recombinant interleukin 6.

1990 • 151 citations

Regulation of thrombopoiesis: effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume

1987 • 150 citations

Regulation of megakaryopoiesis in long-term murine bone marrow cultures

1978 • 144 citations

Recombinant murine granulocyte macrophage colony-stimulating factor has megakaryocyte colony-stimulating activity and augments megakaryocyte colony stimulation by interleukin 3.

1987 • 139 citations

Type beta transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro

1987 • 129 citations

Interleukin-6 and its receptor are expressed by human megakaryocytes: in vitro effects on proliferation and endoreplication

1991 • 123 citations

Megakaryocytopoiesis and platelet production: a review.

1987 • 114 citations

Flow cytometric analysis of normal human megakaryocytes

1988 • 104 citations

Interleukin-1 beta (IL-1 beta) induces thrombocytosis in mice: possible implication of IL-6

1990 • 87 citations

Monoclonal antibodies: Principles and practice : production and application of monoclonal antibodies in cell biology, biochemistry, and immunology

1983 • 81 citations

Stromal cells in myeloid and lymphoid long-term bone marrow cultures can support multiple hemopoietic lineages and modulate their production of hemopoietic growth factors

1986 • 75 citations

Interleukin 6 is a differentiation factor for human megakaryocytes in vitro

1990 • 73 citations

Megakaryocytopoiesis in the mouse: Response to varying platelet demand

1981 • 67 citations

The role of interleukin 6 and interleukin 1 in megakaryocyte development.

1989 • 65 citations

Synergistic regulation of human megakaryocyte development.

1988 • 64 citations

Maturation and regulation of megakaryocytopoiesis.

1979 • 49 citations

Regulators of thrombopoiesis: their biochemistry and physiology.

1989 • 48 citations

Control of Platelet Production

1983 • 44 citations

Recombinant gibbon interleukin‐3 stimulates megakaryocyte colony growth in vitro from human peripheral blood progenitor cells

1988 • 40 citations

Human Megakaryocyte Production: Cell Biology and Clinical Considerations

1990 • 32 citations

The effect of lithium on growth factor production in long-term bone marrow cultures

1987 • 32 citations

Clonal growth of murine pre-B colony-forming cells and their targeted infection by a retroviral vector: dependence on interleukin-7

1990 • 26 citations

The relationship of stromal cells to hemopoietic cells in marrow.

1984 • 19 citations

The role and composition of the adherent layer in long-term bone marrow culture.

1984 • 12 citations

Megakaryocytopoiesis and granulopoiesis of W/Wv mice studied in long- term bone marrow cultures

1985 • 5 citations

Role of the microenvironment on hematopoiesis. II. Regulation of cell kinetics in vitro during granulopoiesis and megakaryocytopoiesis.

1989 • 5 citations

Independence of megakaryocyte number and size in long-term cultures of normal mouse marrow.

1985 • 5 citations

Colony-stimulating factors and their relevance to long-term bone marrow cultures.

1984 • 3 citations

Separate factors control terminal cytoplasmic maturation of human megakaryocytes.

1986 • 3 citations

The differentiation of hematopoietic cells in long-term bone marrow culture.

1984 • 2 citations