Glutamate Dehydrogenase Deficiency in Cerebellar Degenerations: Clinical, Biochemical and Molecular Genetic Aspects

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

PCR protocols — A guide to methods and applications

1990 • 10,078 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

L-Glutamate Dehydrogenases* *Research work cited in this review which originates in the author's laboratory was supported in part by research grant AM 13332, United States Public Health Service and research grant GB 26583X from the National Science Foundation.

1971 • 533 citations

Glutamate acting on NMDA receptors stimulates neurite outgrowth from cerebellar granule cells

1987 • 316 citations

AMPLIFICATION OF GENOMIC DNA

1990 • 267 citations

Effects of 3-acetylpyridine on the central nervous system of the rat, as demonstrated by silver methods

1974 • 240 citations

Abnormal Glutamate Metabolism in an Adult-Onset Degenerative Neurological Disorder

1982 • 227 citations

Stimulation of the receptor has a trophic effect on differentiating cerebellar granule cells

1988 • 212 citations

Neurological disorders associated with deficiency of glutamate dehydrogenase

1984 • 183 citations

DNA amplification by the polymerase chain reaction

1990 • 168 citations

Regional distribution of astrocytes with intense immunoreactivity for glutamate dehydrogenase in rat brain: implications for neuron-glia interactions in glutamate transmission

1987 • 159 citations

Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol‐rich liposomes

1988 • 149 citations

HIGH AFFINITY UPTAKE OF L‐GLUTAMATE AND L‐ASPARTATE BY GLIAL CELLS

1977 • 132 citations

Glutamate dehydrogenase deficiency in three patients with spinocerebellar syndrome

1980 • 111 citations

Purification and Characterization of a Soluble and a Particulate Glutamate Dehydrogenase from Rat Brain

1986 • 106 citations

Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family.

1988 • 92 citations

Characterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines

1989 • 86 citations

THE PURIFICATION AND PROPERTIES OF RAT BRAIN GLUTAMATE DEHYDROGENASE

1979 • 80 citations

Glutamate dehydrogenase deficiency in patients with olivopontocerebellar atrophy

1983 • 76 citations

Spinocerebellar ataxia in a large kindred

1984 • 72 citations

The Human Glutamate Dehydrogenase Gene Family: Gene Organization and Structural Characterization

1993 • 64 citations

Spinocerebellar ataxia: localization of an autosomal dominant locus between two markers on human chromosome 6.

1987 • 51 citations

Crossed cerebellar and uncrossed basal ganglia and thalarnic diaschisis in Alzheimer's disease

1989 • 45 citations

Autoradiographic localization of inhibitory and excitatory amino acid neurotransmitter receptors in human normal and olivopontocerebellar atrophy cerebellar cortex

1990 • 41 citations

Functional Disorders of the Brain Induced by Synthesis of Nucleotides Containing 3-Acetylpyridine

1968 • 41 citations

Glutamate dehydrogenase deficiency in spinocerebellar degenerations

1982 • 38 citations

Glutamate dehydrogenase in olivopontocerebellar atrophies: leukocytes,fibroblasts, and muscle mitochondria

1986 • 36 citations

Glutamate dehydrogenase and its isozyme activity in olivopontocerebellar atrophy

1986 • 34 citations

Morphological changes of olivopontocerebellar atrophy in computed tomography and comments on its pathogenesis.

1984 • 34 citations

Neurophysiologic study of olivopontocerebellar atrophy with or without glutamate dehydrogenase deficiency

1985 • 32 citations

Leukocyte glutamate dehydrogenase activity in patients with degenerative neurological disorders.

1988 • 29 citations

Abnormal platelet glutamate dehydrogenase activity and activation in dominant and nondominant olivopontocerebellar atrophy

1986 • 29 citations

Partially deficient glutamate dehydrogenase activity and attenuated oscillatory potentials in patients with spinocerebellar degeneration.

1992 • 28 citations

Metabolism of Glutamate and Glutamine in Neurons and Astrocytes in Primary Cultures

2018 • 27 citations

Isolation of a Human Brain cDNA for Glutamate Dehydrogenase

1987 • 27 citations

Lymphocyte Glutamate Dehydrogenase Activity in Normal Aging and Neurological Diseases

1989 • 26 citations

Low leukocyte glutamate dehydrogenase activity does not correlate with a particular type of multiple system atrophy.

1988 • 23 citations

Decreased glutamate dehydrogenase protein in spinocerebellar degeneration.

1988 • 20 citations

L-Glutamate binding sites of normal and atrophic human cerebellum

1989 • 20 citations

Presence of a TaqI polymorphism in the human glutamate dehydrogenase (GLUD) gene on chromosome 10

1987 • 18 citations

Staphylococcal meningitis

1985 • 17 citations

Abnormalities of mitochondrial enzymes in hereditary ataxias

1989 • 16 citations

Abnormal metabolism of neuroexcitatory amino acids in olivopontocerebellar atrophy.

1984 • 15 citations

Degenerative neurological disorders associated with deficiency of glutamate dehydrogenase

1989 • 13 citations

Isolation and characterization of the two distinct genes for human glutamate dehydrogenase

1990 • 11 citations

Quantitative autoradiographic study of L‐glutamate binding sites in normal and atrophic human cerebellum

1991 • 10 citations

Classification and Epidemiology of Cerebellar Degenerations

1992 • 10 citations

Glutamate dehydrogenase deficiency in three patients with spinocerebellar ataxia: a new enzymatic defect?

1979 • 9 citations

Glutamate dehydrogenase (GDH) deficiency in different types of progressive hereditary cerebellar ataxia

1988 • 9 citations

Decreased viability of skin fibroblasts from patients with glutamate dehydrogenase deficiency

1989 • 9 citations

Oral glutamate loading in disorders with spinocerebellar and extrapyramidal involvement: effect on plasma glutamate, aspartate and taurine.

1983 • 9 citations

Leukocyte glutamate dehydrogenase and CSF amino acids in late onset ataxias

2009 • 8 citations

Assignment of the GDH loci to human chromosomes 10q23 and Xq24 by in situ hybridization.

1989 • 8 citations

Cerebellar ataxia with glutamic aciduria

1991 • 5 citations

The value of computerized tomography in the diagnosis of cerebellar atrophy

1983 • 3 citations