Unsaturated fatty acids activate glycogen phosphorylase in cultured rat hepatocytes

THE GLUCOSE FATTY-ACID CYCLE ITS ROLE IN INSULIN SENSITIVITY AND THE METABOLIC DISTURBANCES OF DIABETES MELLITUS

1963 • 5,061 citations

Effect of fatty acids on glucose production and utilization in man.

1983 • 1,056 citations

Albumin—An important extracellular antioxidant?

1988 • 643 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Fluorometric Determination of Corticosterone and Cortisol in 0.02–0.05 Milliliters of Plasma or Submilligram Samples of Adrenal Tissue1

1964 • 540 citations

The effects of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations

1975 • 357 citations

The Stimulation of Liver Phosphorylase b by AMP, Fluoride and Sulfate

1975 • 313 citations

Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

1986 • 310 citations

Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids.

1986 • 309 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Control of hepatic glycogenolysis.

1980 • 288 citations

Free–Fatty Acid Inhibition of Insulin Binding, Degradation, and Action in Isolated Rat Hepatocytes

1990 • 252 citations

Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects

1987 • 240 citations

Stimulation of inositol trisphosphate formation in hepatocytes by vasopressin, adrenaline and angiotensin II and its relationship to changes in cytosolic free Ca2+

1985 • 212 citations

The Sequential Inactivation of Glycogen Phosphorylase and Activation of Glycogen Synthetase in Liver after the Administration of Glucose to Mice and Rats

1974 • 206 citations

Regulation of protein kinase C activity by lipids

1988 • 155 citations

Oleic acid promotes the activation and translocation of phosphatidate phosphohydrolase from the cytosol to particulate fractions of isolated rat hepatocytes

1984 • 153 citations

Polyunsaturated free fatty acids stimulate an increase in cytosolic Ca2+ by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in T cells through a mechanism independent of phosphoinositide turnover.

1990 • 144 citations

Membrane Adenosinetriphosphatase: A Digitalis Receptor?

1977 • 143 citations

INFLUENCE OF FREE FATTY ACID CONCENTRATION ON DRUG BINDING TO PLASMA ALBUMIN*

1973 • 133 citations

Release of calcium from the endoplasmic reticulum by bile acids in rat liver cells.

1988 • 127 citations

The role of extracellular Ca2+ in the response of the hepatocyte to Ca2+-dependent hormones.

1985 • 117 citations

Complications of Diabetes

1983 • 113 citations

Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum

1981 • 99 citations

Hormone-Calcium Interactions with the Plasma Membrane of Rat Liver Cells

1972 • 92 citations

Effects of cyclic AMP, glucocorticoids and insulin on the activities of phosphatidate phosphohydrolase, tyrosine aminotransferase and glycerol kinase in isolated rat hepatocytes in relation to the control of triacylglycerol synthesis and gluconeogenesis

1985 • 88 citations

The effects of glucocorticoids on insulin-stimulated lipogenesis in primary cultures of rat hepatocytes

1983 • 84 citations

A possible molecular mechanism of the action of digitalis: ouabain action on calcium binding to sites associated with a purified sodium-potassium-activated adenosine triphosphatase from kidney.

1977 • 83 citations

Metabolic responses of the heart in acute myocardial infarction in man

1978 • 82 citations

The involvement of glucocorticoids in regulating the activity of phosphatidate phosphohydrolase and the synthesis of triacylglycerols in the liver. Effects of feeding rats with glucose, sorbitol, fructose, glycerol and ethanol

1979 • 66 citations

Glucagon and vasopressin interactions on Ca2+ movements in isolated hepatocytes

1986 • 66 citations

Effect of plasma albumin on sodium reabsorption in patients with nephrotic syndrome

1972 • 60 citations

Effects of chronic modification of dietary fat and carbohydrate on the insulin, corticosterone and metabolic responses of rats fed acutely with glucose, fructose or ethanol

1981 • 58 citations

Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes

1984 • 50 citations

Inhibition of receptor-mediated calcium influx in T cells by unsaturated non-esterified fatty acids

1990 • 50 citations

fatty acids modulate calcium-induced calcium release from skeletal muscle heavy sarcoplasmic reticulum fractions: implications for mallignant hyperthermia

1990 • 47 citations

Fatty acid specificity for the synthesis of triacylglycerol and phosphatidylcholine and for the secretion of very-low-density lipoproteins and lysophosphatidylcholine by cultures of rat hepatocytes

1988 • 45 citations

Liver Phosphorylase b Kinase

1979 • 44 citations

Control of glycogen phosphorylase interconversion by phorbol esters, diacylglycerols, Ca2+ and hormones in isolated rat hepatocytes

1985 • 43 citations

Mechanism of arachidonic acid-induced Ca2+ mobilization from rat liver microsomes

1987 • 40 citations

Inactivation and reactivation of liver phosphorylase kinase

1977 • 37 citations

Arachidonic acid‐induced release of calcium in permeabilized human neutrophils

1987 • 34 citations

Control of hepatic triacylglycerol synthesis. Diurnal variations in hepatic phosphatidate phosphohydrolase activity and in the concentrations of circulating insulin and corticosterone in rats

1979 • 33 citations

Rapid activation of glycogen phosphorylase by steroid hormones in cultured rat hepatocytes

1989 • 32 citations

Estrogen Stimulation of Phosphatidylinositol Metabolism in Mouse Uterine Tissue

1987 • 32 citations

On the mechanism by which glucocorticoids cause the activation of glycogen synthase in mouse and rat livers

1983 • 30 citations

Mechanisms of hormonal regulation of liver metabolism.

1981 • 29 citations

Regulation of transmembrane ion transport by reaction products of phospholipase A2. II. Effects of arachidonic acid and other fatty acids on mitochondrial Ca2+ transport

1989 • 24 citations

Interactions of insulin and dexamethasone in the control of pyruvate kinase activity and glucose metabolism in sheep adipose tissue

1987 • 24 citations

Characterization of cortisol binding sites in chicken liver plasma membrane

1987 • 23 citations

Dexamethasone affects phosphatidylinositol synthesis and degradation in cultured human embryonic cells

1983 • 22 citations

Evidence for Ca2+ mobilizing action of arachidonic acid in human platelets

1989 • 20 citations

Mechanisms of catecholamine actions on liver carbohydrate metabolism.

1978 • 19 citations

Control of Glycogen Synthase and Phosphorylase in Hepatocytes From Diabetic Rats: Effects of Glucagon, Vasopressin, and Vanadate

1989 • 16 citations

Inhibition of human neutrophil aggregation by albumin. Relationship with cytoskeleton reorganization

1989 • 11 citations

Palmitic acid stimulates glucose incorporation in the adipocyte by a mechanism likely involving intracellular calcium.

1989 • 11 citations

Altered regulation of glycogen metabolism by vasopressin and phenylephrine in hepatocytes from insulin-resistant obese (fa/fa) rats. Role of protein kinase C

1990 • 9 citations

Fatty acid alters glycogen metabolism in contracting vascular smooth muscle

1989 • 6 citations

cAMP-independent stimulation of glycogen phosphorylase in newborn rat hepatocytes

1985 • 6 citations

Transient changes in phospholipid methylation induced by dexamethasone in lymphoid cells.

1983 • 5 citations