Cloning and characterization of human SHIP, the 145-kD inositol 5- phosphatase that associates with SHC after cytokine stimulation

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Protein modules and signalling networks

1995 • 2,447 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

High-Resolution Mapping of Human Chromosome 11 by in Situ Hybridization with Cosmid Clones

1990 • 1,357 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

A presynaptic inositol-5-phosphatase

1996 • 573 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase

1992 • 464 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Modes of DAPI banding and simultaneous in situ hybridization

1993 • 397 citations

Lipid second messengers

1994 • 357 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

Selective growth response to IL‐3 of a human leukaemic cell line with megakaryoblastic features

1988 • 314 citations

The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase.

1995 • 266 citations

Proline-rich sequences that bind to Src homology 3 domains with individual specificities.

1995 • 257 citations

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

1993 • 238 citations

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein

1993 • 203 citations

Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc.

1994 • 187 citations

The Many Roads That Lead to Ras

1993 • 185 citations

The GRB2/Sem‐5 adaptor protein

1994 • 182 citations

B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.

1994 • 169 citations

The role of p21ras in receptor tyrosine kinase signaling

1995 • 166 citations

Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.

1994 • 161 citations

Activation of Ras by receptor tyrosine kinases.

1994 • 160 citations

Brachydactyly and mental retardation: an Albright hereditary osteodystrophy-like syndrome localized to 2q37.

1995 • 135 citations

Properties of Type II Inositol Polyphosphate 5-Phosphatase

1995 • 127 citations

Phosphoinositide 3-kinases and membrane traffic

1996 • 124 citations

Shc, Grb2, Sosl, and a 150-Kilodalton Tyrosine-Phosphorylated Protein Form Complexes with Fms in Hematopoietic Cells

1994 • 119 citations

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

1996 • 104 citations

B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins.

1994 • 89 citations

A Single Point Mutation Switches the Specificity of Group III Src Homology (SH) 2 Domains to That of Group I SH2 Domains

1995 • 81 citations

Rapid physical mapping of cloned DNA on banded mouse chromosomes by fluorescence in situ hybridization

1992 • 78 citations

Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line

1992 • 77 citations

Deletion of the PEST-like Region of Photosystem Two Modifies the QB-binding Pocket but Does Not Prevent Rapid Turnover of D1

1995 • 76 citations

Affinity, Specificity, and Kinetics of the Interaction of the SHC Phosphotyrosine Binding Domain with Asparagine-X-X-Phosphotyrosine Motifs of Growth Factor Receptors

1996 • 68 citations

Cloning and Characterization of a Human cDNA (INPPL1) Sharing Homology with Inositol Polyphosphate Phosphatases

1995 • 43 citations

Isolation and initial characterization of a large repeat sequence element specific to mouse chromosome 8

1992 • 43 citations

Synergistic effects of inositol 1,3,4,5-tetrakisphosphate on inositol 2,4,5-triphosphate-stimulated Ca2+ release do not involve direct interaction of inositol 1,3,4,5-tetrakisphosphate with inositol triphosphate-binding sites

1996 • 41 citations

Single amino‐acid replacement is responsible for the stabilization of ornithine decarboxylase in HMO_A cells

1993 • 34 citations