Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients

The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.

1994 • 6,682 citations

Multiple Organ Dysfunction Score

1995 • 2,453 citations

Triggering and modulation of apoptosis by oxidative stress

2000 • 1,315 citations

Simultaneous determination of α-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography

1979 • 1,013 citations

Vitamin E Supplementation and In Vivo Immune Response in Healthy Elderly Subjects

1997 • 541 citations

Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome.

1996 • 517 citations

In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation.

1996 • 490 citations

Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction

1995 • 479 citations

Early Predictors of Postinjury Multiple Organ Failure

1994 • 470 citations

A Trial of Antioxidants N-acetylcysteine and Procysteine in ARDS

1997 • 409 citations

Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome.

1994 • 407 citations

Regulation of interleukin 8 gene expression by oxidant stress.

1993 • 395 citations

Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk

1996 • 342 citations

N-Acetylcysteine Enhances Recovery From Acute Lung Injury in Man

1994 • 322 citations

Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients

1996 • 314 citations

Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes.

1993 • 304 citations

Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome

1996 • 288 citations

Antioxidant status in patients with acute respiratory distress syndrome

1999 • 257 citations

Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome

1992 • 247 citations

Exhaled Breath Condensate Isoprostanes Are Elevated in Patients With Acute Lung Injury or ARDS

1998 • 236 citations

Increased Hydrogen Peroxide in the Expired Breath of Patients with Acute Hypoxemic Respiratory Failure

1989 • 225 citations

Oxidized Glutathione Is Increased in the Alveolar Fluid of Patients with the Adult Respiratory Distress Syndrome

1993 • 206 citations

Plasma antioxidant potential in severe sepsis

1996 • 201 citations

Vitamin E deficiency and lipoperoxidation during adult respiratory distress syndrome

1990 • 170 citations

Hydrogen peroxide-induced increase in endothelial adhesiveness is dependent on ICAM-1 activation

1993 • 166 citations

Safety of Bronchoalveolar Lavage in Patients with Adult Respiratory Distress Syndrome

1993 • 161 citations

Safety of antioxidant vitamins and beta-carotene

1995 • 137 citations

Circulating xanthine oxidase mediates lung neutrophil sequestration after intestinal ischemia-reperfusion

1992 • 130 citations

Vitamin C intake and susceptibility to pneumonia

1997 • 125 citations

Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial

1997 • 119 citations

Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome

1996 • 115 citations

Antioxidant Therapy in the Prevention of Organ Dysfunction Syndrome and Infectious Complications after Trauma: Early Results of a Prospective Randomized Study

1999 • 100 citations

Pyrrolidine Dithiocarbamate Attenuates Endotoxin-induced Acute Lung Injury

1997 • 88 citations

Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock.

1995 • 87 citations

N-ACETYL CYSTEINE ATTENUATES ACUTE LUNG INJURY IN THE RAT

1995 • 85 citations

Isoprostanes

1994 • 82 citations

N-ACETYL CYSTEINE ATTENUATES ACUTE LUNG INJURY IN THE RAT

1997 • 76 citations

Plasma redox status relates to severity in critically ill patients

2000 • 73 citations

Differences in tocopherol-lipid ratios in ARDS and non-ARDS patients

1989 • 60 citations

Refilling the inositol 1,4,5-trisphosphate-sensitive Ca2+ store in neuroblastoma x glioma hybrid NG108-15 cells

1993 • 40 citations

Enteral Vitamin E Supplementation Inhibits the Cytokine Response to Endotoxin

1997 • 37 citations

A Randomized Trial of Replacement Antioxidant Vitamin Therapy for Neutrophil Locomotory Dysfunction in Blunt Trauma

1991 • 35 citations

Effect of vitamin E deficiency and supercritical fluid aerosolized vitamin E supplementation on interleukin-1-induced oxidative lung injury in rats

1995 • 34 citations

A Randomized Trial of Replacement Antioxidant Vitamin Therapy for Neutrophil Locomotory Dysfunction in Blunt Trauma

1991 • 30 citations

The effect of N-acetylcysteine on total serum anti-oxidant potential and urinary albumin excretion in critically ill patients

1998 • 30 citations