The Control of Gene Expression in Somatic Cell Hybrids

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Doctoral Dissertation

1987 • 2,700 citations

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1970 • 759 citations

Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei

1970 • 699 citations

Propagation in Tissue Cultures of Cytopathogenic Agents from Patients with Measles.

1954 • 664 citations

A method for high-frequency intergeneric fusion of plant protoplasts

1974 • 623 citations

Hybrid Cells Derived from Mouse and Man : Artificial Heterokaryons of Mammalian Cells from Different Species

1965 • 608 citations

Two Types of Ribosome in Mouse–Hamster Hybrid Cells

1971 • 577 citations

Production of mammalian somatic cell hybrids by means of polyethylene glycol treatment

1975 • 549 citations

The Cell Nucleus

1966 • 522 citations

Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes.

1967 • 517 citations

Differentiation in erythroleukemic cells and their somatic hybrids.

1975 • 447 citations

Ouabain-resistant mutants of mouse and hamster cells in culture

1974 • 393 citations

Lysolecithin and Cell Fusion

1970 • 350 citations

Artificial heterokaryons of animal cells from different species

1966 • 340 citations

The fusion of erythrocytes by fatty acids, esters, retinol and α-tocopherol

1973 • 282 citations

Location of the genes coding for 18S and 28S ribosomal RNA in the human genome

1974 • 278 citations

Analysis of giant polynuclear cell formation caused by HVJ virus from Ehrlich's ascites tumor cells

1962 • 266 citations

Hybridization of Somatic Cells

2015 • 258 citations

Enucleation of mammalian cells with cytochalasin B

1972 • 246 citations

CONTROLLED PRODUCTION OF PROLIFERATING SOMATIC CELL HYBRIDS

1970 • 239 citations

Fusion of mammalian cells by unilamellar lipid vesicles: Influence of lipid surface charge, fluidity and cholesterol

1973 • 236 citations

Transfer of Genetic Information by Purified Metaphase Chromosomes

1973 • 236 citations

Genetics of somatic mammalian cells. V. Treatment with 5-bromodeoxyuridine and visible light for isolation of nutritionally deficient mutants.

1967 • 222 citations

Linkage Analysis in Man by Somatic Cell Genetics

1973 • 184 citations

GENE EXPRESSION IN SOMATIC CELL HYBRIDS

1974 • 183 citations

Genetic Dissection of Neural Properties using Somatic Cell Hybrids

1972 • 178 citations

Mechanisms of Virus-Induced Cell Fusion

1972 • 171 citations

High activity of choline acetyltransferase induced in neuroblastoma X glia hybrid cells

1974 • 164 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids: Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Fibroblast Hybrids

1972 • 158 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids: Reappearance of Tyrosine Aminotransferase Inducibility after the Loss of Chromosomes

1971 • 154 citations

Social Values and Research in Human Embryology

1971 • 149 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids, I. Tyrosine Aminotransferase in Hepatoma-Fibroblast Hybrids

1971 • 146 citations

MAMMALIAN CELL GENETICS I. SELECTION AND CHARACTERIZATION OF MUTATIONS AUXOTROPHIC FOR L-GLUTAMINE OR RESISTANT TO 8-AZAGUANINE IN CHINESE HAMSTER CELLS IN VITRO

1969 • 145 citations

Genetics of Somatic Mammalian Cells: Linkage Studies with Human–Chinese Hamster Cell Hybrids

1970 • 141 citations

The Synthesis and Stability of Cytoplasmic Messenger RNA During Myoblast Differentiation in Culture

1974 • 140 citations

Temperature Sensitive Mutants of BHK 21 Cells

1972 • 138 citations

NUCLEO‐CYTOPLASMIC INTERACTIONS IN THE ACHIEVEMENT OF NUCLEAR SYNCHRONY IN DNA SYNTHESIS AND MITOSIS IN MULTINUCLEATE CELLS

1971 • 133 citations

RETENTION OF MULTIPLE DEVELOPMENTAL POTENTIALITIES BY CELLS OF A MOUSE TESTICULAR TERATOCARCINOMA DURING PROLONGED CULTURE in vitro AND THEIR EXTINCTION UPON HYBRIDIZATION WITH CELLS OF PERMANENT LINES

1967 • 129 citations

Genes for Neuronal Properties Expressed in Neuroblastoma × L Cell Hybrids

1971 • 128 citations

Assignment of the Gene for Adenine Phosphoribosyltransferase to Human Chromosome 16 by Mouse-Human Somatic Cell Hybridization

1974 • 123 citations

Genetics of Somatic Mammalian Cells: Lethal Antigens as Genetic Markers for Study of Human Linkage Groups

1971 • 121 citations

Preparation of microcells by enucleation of micronucleate cells

1974 • 121 citations

Somatic cell hybridization

1975 • 121 citations

Transfer of the human gene for hypoxanthine-guanine phosphoribosyltransferase via isolated human metaphase chromosomes into mouse L-cells.

1975 • 120 citations

Ribosomal RNA synthesis in human-mouse hybrid cells

1969 • 114 citations

Human × Mouse Somatic Cell Hybrid Clone secreting Immunoglobulins of both Parental Types

1973 • 110 citations

Antimitotic Action of Griseofulvin does not Involve Disruption of Microtubules

1973 • 108 citations

Properties and Uses of Human–Mouse Hybrid Cell Lines

1968 • 108 citations

Induction of Directional Chromosome Elimination in Somatic Cell Hybrids

1971 • 106 citations

Human chromosome 19 carries a poliovirus receptor gene

1974 • 100 citations

MAPPING OF A HUMAN GENETIC REGULATOR ELEMENT BY SOMATIC CELL GENETIC ANALYSIS

1970 • 99 citations

Human Serum Albumin Phenotype Activation in Mouse Hepatoma-Human Leukocyte Cell Hybrids

1974 • 96 citations

Effect of Environmental pH on the Efficiency of Cellular Hybridization

1972 • 94 citations

MACROPHAGE-MELANOCYTE HETEROKARYONS

1970 • 91 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids: High Frequency of Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Lymphoblast Hybrids

1974 • 88 citations

A New Reduced Human-Mouse Somatic Cell Hybrid Containing the Human Gene for Adenine Phosphoribosyltransferase

1971 • 87 citations

Induction of Auxotrophic Mutations by Treatment of Chinese Hamster Cells with 5-Bromodeoxyuridine and Black Light

1972 • 86 citations

Reconstruction of Mammalian Cells from Nuclear and Cytoplasmic Components Separated by Treatment with Cytochalasin B

1974 • 81 citations

Gene Dosage Dependence of Pigment Synthesis in Melanoma x Fibroblast Hybrids

1972 • 81 citations

EVIDENCE FOR INTERGENIC COMPLEMENTATION IN HYBRID CELLS DERIVED FROM TWO HUMAN DIPLOID STRAINS EACH CARRYING AN X-LINKED MUTATION

1969 • 81 citations

Expression of differentiated functions in hepatoma cell hybrids

1972 • 78 citations

Expression of neuronal phenotypes in neuroblastoma cell hybrids

1974 • 78 citations

STUDIES OF INTERSPECIFIC (RAT x MOUSE) SOMATIC HYBRIDS. I. ISOLATION, GROWTH AND EVOLUTION OF THE KARYOTYPE

1966 • 78 citations

Expression of differentiated functions in hepatoma cell hybrids: IX extinction and reexpression of liver-specific enzymes in rat hepatoma-Chinese hamster fibroblast hybrids

1975 • 78 citations

Somatic cell hybridization

1974 • 70 citations

Studies on chemically induced cell fusion

1972 • 70 citations

Human gene expression in rodent cells after uptake of isolated metaphase chromosomes.

1975 • 69 citations

The mammalian cell as a microorganism

1960 • 68 citations

Regulation of Melanin Synthesis in Mammalian Cells: Effect of Gene Dosage on the Expression of Differentiation

1972 • 67 citations

Hybridization of a malignant melanoma cell line with L cells in vitro.

1967 • 67 citations

Human Regulatory Gene for Inducible Tyrosine Aminotransferase in Rat-Human Hybrids

1973 • 66 citations

Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization

1969 • 65 citations

Suppression of Immunoglobulin Synthesis by Cellular Hybridization

1971 • 65 citations

Regulation of Specific Functions of Glial Cells in Somatic Hybrids, II. Control of Inducibility of Glycerol-3-Phosphate Dehydrogenase

1970 • 63 citations

Characterization of minicells (nuclei) obtained by cytochalasin enucleation

1974 • 62 citations

Premature chromosome condensation: a mechanism for the elimination of chromosomes in virus-fused cells

1972 • 62 citations

Human x mouse hybrid cells segregating mouse chromosomes and isozymes

1974 • 60 citations

A temperature‐sensitive function in a Chinese hamster line affecting DNA synthesis

1973 • 60 citations

Detection of Human and Chick Nuclear Antigens in Nuclei of Chick Erythrocytes during Reactivation in Heterokaryons with HeLa Cells

1971 • 59 citations

Hybrid Cell Line from a Cloned Immunoglobulin-Producing Mouse Myeloma and a Nonproducing Mouse Lymphoma

1971 • 59 citations

Interspecific hybridization between human and mouse somatic cells: Enzyme and linkage studies

1969 • 57 citations

Incorporation of isolated chromosomes and induction of hypoxanthine phosphoribosyltransferase in chinese hamster cells

1975 • 57 citations

Preferential retention of the human chromosome C-7 in human-(thymidine kinase deficient) mouse hybrid cells

1973 • 56 citations

Genetics of somatic mammalian cells XII: Mutagenesis by carcinogenic nitroso compounds

1971 • 56 citations

Genetic analysis of the cell surface: association of human chromosome 5 with sensitivity to diphtheria toxin in mouse-human somatic cell hybrids.

1975 • 55 citations

Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase

1972 • 54 citations

Control Mechanisms in Developmental Processes

1968 • 54 citations

Introduction of nuclei and micronuclei into cells and enucleated cytoplasms by sendai virus induced fusion

1974 • 52 citations

Genetics of somatic mammalian cells. XIV. Genetic analysis in vitro of auxotrophic mutants

1972 • 52 citations

Lack of expression of differentiation in mouse teratoma-fibroblast somatic cell hybrids

1973 • 52 citations

Use of somatic cell hybrids for analysis of the differentiated state.

1973 • 51 citations

Influence of Noradrenalin, Prostaglandin E₁and Inhibitors of Phosphodiesterase Activity on Levels of the Cyclic Adenosine 3′:5′-monophosphate in Somatic Cell Hybrids

1973 • 50 citations

Expression of Genes for Metabolism of Cyclic Adenosine 3′:5′-Monophosphate in Somatic Cells

1973 • 50 citations

Dopamine‐β‐hydroxylase activity in cholinergic neuroblastoma × glioma hybrid cells; increase of activity by N⁶,O²′‐dibutyryl adenosine 3′: 5′‐cyclic monophosphate

1974 • 49 citations

ISOLATION AND PROPERTIES OF HYBRIDS BETWEEN SOMATIC MOUSE AND CHINESE HAMSTER CELLS

1967 • 49 citations

Hybridization of somatic cells derived from mouse and Syrian hamster: Evolution of karyotype and enzyme studies

1968 • 48 citations

Cell cycles and chromosome replication patterns in interspecific somatic hybrids

1972 • 47 citations

THE RIBOSOMAL RNA OF HAMSTER-MOUSE HYBRID CELLS

1972 • 46 citations

INDUCTION AND ANALYSIS OF GENE MUTATIONS IN CULTURED MAMMALIAN SOMATIC CELLS

1974 • 46 citations

Chinese hamster cells exhibiting a temperature dependent alteration in purine transport

1974 • 45 citations

IgG Synthesis in Hybrid Cells from an Antibody-producing Mouse Myeloma and an L Cell Substrain

1970 • 44 citations

DNA synthesis in rabbit spermatozoa after treatment with lysolecithin and fusion with somatic cells

1972 • 43 citations

Expression of Differentiated Functions in Hepatoma Cell Hybrids: Alanine Aminotransferase

1973 • 43 citations

Non–random loss of human markers from man–mouse somatic cell hybrids

1974 • 42 citations

Mitosis in Hybrid Cells Derived from Mouse and Man

1965 • 42 citations

Selection of chromosomal segregants in a “hybrid” line of syrian hamster fibroblasts

1969 • 42 citations

Recombination and Segregation in Somatic Cell Hybrids

1969 • 41 citations

Griseofulvin: A potential agent of chromosomal segregation in cultured cells

1974 • 41 citations

Chapter 3 Cell Fusion and Its Application to Studies on the Regulation of the Cell Cycle

1972 • 40 citations

Cell Cycle Changes and the Ability of Cells to Undergo Virus-Induced Fusion

1972 • 39 citations

Isolation and characterization of hybrids between mouse and Chinese hamster cell lines

1970 • 37 citations

Loss of growth hormone production following hybridization of a functional rat pituitary cell strain with a mouse fibroblast line*1

1971 • 37 citations

The Selection of Hybrid Mouse Fibroblasts

1964 • 37 citations

Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. II. The level of regulation of 3,4-dihydroxyphenylalanine oxidase.

1968 • 37 citations

Human intraspecific somatic cell hybrids: A genetic and karyotypic analysis of crosses between lymphocytes and D98/AH-2

1975 • 36 citations

Genetics of somatic mammalian cells. XV. Evidence for linkage between human genes for lactic dehydrogenase B and serine hydroxymethylase

1972 • 35 citations

Regulation of specific functions of glial cells in somatic hybrids. I. Control of S100 protein

1971 • 34 citations

Directed Chromosome Loss by Laser Microirradiation

1974 • 33 citations

Chromosome Assignment of the Human Gene for Galactose-1-phosphate Uridyltransferase

1974 • 33 citations

SURFACE ANTIGENS OF MAMMALIAN CELLS AS GENETIC MARKERS. II

1973 • 33 citations

Preferential segregation of homospecific groups of chromosomes in heterospecific somatic cell hybrids

1972 • 32 citations

Ribosomal RNA synthesis in human-mouse hybrid cells

1971 • 32 citations

Expression of Aryl Hydrocarbon Hydroxylase Induction and Suppression of Tyrosine Aminotransferase Induction in Somatic-Cell Hybrids

1972 • 32 citations

Expression of Genes for Metabolism of Cyclic Adenosine 3′:5′-Monophosphate in Somatic Cells

1973 • 30 citations

Lysolecithin-induced fusion of fibroblasts

1972 • 30 citations

A human-mouse somatic hybrid line selected for human deoxycytidine deaminase

1975 • 30 citations

Expression of the neuron‐specific protein, 14‐3‐2, and steroid sulfatase in neuroblastoma cell hybrids

1974 • 28 citations

Electrical excitability and chemosensitivity of mouse neuroblastoma x mouse or human fibroblast hybrids

1973 • 26 citations

Localization of the 5S Ribosomal RNA Genes in the Human Genome

1974 • 26 citations

Fusion of Mammalian Somatic Cells by Microsurgery

1972 • 25 citations

Karyological Properties of Human-Mouse Somatic Hybrids

1971 • 24 citations

Immunoglobulin G and Free Kappa-Chain Synthesis in Different Clones of a Hybrid Cell Line

1971 • 24 citations

Dna synthesis and mitosis in fused cells: III. HeLa-Ehrlich heterokaryons

1969 • 23 citations

Location of the Genes for 5S RNA in the Human Chromosome Complement

1974 • 22 citations

Tabulation of somatic cell hybrids formed between lines of cultured cells

1972 • 20 citations

Genetics and the Animal Cell

1975 • 20 citations

Some aspects of somatic cell hybridization

1970 • 19 citations

Establishment of a Tetraploid, Immunoglobulin-Producing Cell Line from the Hybridization of Two Human Lymphocyte Lines

1974 • 18 citations

Glyceryl monooleate as a fusogen for the formation of heterokaryons and interspecific hybrid cells

1974 • 18 citations

Biochemical and Cytological Evidence for Triple Hybrid Cell Line Formed from Fusion of Three Different Cells

1971 • 18 citations

Genetics and the animal cell

1974 • 17 citations

Lambda-Chain Production in Human Lymphoblast-Mouse Fibroblast Hybrids

1973 • 15 citations

Patterns of late chromosomal DNA replication in unbalanced chinese hamster-mouse somatic cell hybrids*1

1974 • 15 citations

Microsurgically Fused Human Somatic Cell Hybrids: Analysis and Cloning

1973 • 14 citations

Expression of the myosin gene in a hybrid cell derived from a rat myoblast and a mouse fibroblast

1975 • 14 citations

Somatic cell hybridization: Pattern of chromosome replication in viable Chinese hamster X Armenian hamster hybrids

1970 • 12 citations

6-Hydroxydopamine sensitivity in mouse neuroblastoma and neuroblastoma x L-cell hybrids.

1974 • 11 citations

Relationship between the ratio of parental chromosomes and parental doubling times in chinese hamster‐mouse somatic cell hybrids

1973 • 11 citations

Some observations on the Formation of Giant Cells in Tissue Cultures of Chicken Macrophages

1958 • 11 citations

Induction of somatic fusion and heterokaryosis in two incompatible strains ofPhysarum polycephalum

1974 • 8 citations

Heterokaryons in the analysis of genes and gene regulation

1975 • 8 citations

Expression of differentiated properties in fetal liver cells and their somatic cell hybrids

1973 • 7 citations

Introduction of mouse L cell nucleus into heterologous mammalian cells

1974 • 5 citations

Endogenic Cratering Distribution on the Moon

1973 • 4 citations

Cytoplasmic ribosomal RNA of hamster-mouse hybrid cells

1973 • 4 citations

The Expression of Hepatic Functions in Mouse Hepatoma × Human Leukocyte Hybrids

1974 • 4 citations

Somatic Cell Hybridization: studies on genetics and development

1974 • 4 citations