Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety

Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors

1981 • 848 citations

Mechanism of Action of Benzodiazepines

1976 • 437 citations

Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology

1987 • 421 citations

Serotonergic Responsivity in Obsessive-Compulsive Disorder

1987 • 378 citations

Evidence that mCPP may have behavioural effects mediated by central 5‐HT_1C receptors

1988 • 299 citations

Serotonergic Responsivity in Obsessive-Compulsive Disorder

1988 • 299 citations

Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists

1989 • 285 citations

Evidence that hypophagia induced bymCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors

1988 • 257 citations

Serotonin and anxiety revisited

1988 • 253 citations

Tryptophan-5-hydroxylase: function and control.

1974 • 237 citations

A subfamily of 5-HT1D receptor genes

1992 • 230 citations

The Influence of Ritanserin, a Serotonin Antagonist, in Anxiety Disorders: A Double-blind Placebo-controlled Study versus Lorazepam

1985 • 223 citations

Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors.

1987 • 217 citations

An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

1989 • 192 citations

Cloning and functional characterization of the rat stomach fundus serotonin receptor.

1992 • 192 citations

5-HT1B agonists induce anorexia at a postsynaptic site

1987 • 176 citations

Zacopride: anxiolytic profile in rodent and primate models of anxiety

1988 • 170 citations

Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist?

1989 • 168 citations

Distribution of serotonin 5‐HT_1C receptor mRNA in adult rat brain

1989 • 161 citations

Potencies of antagonists indicate that 5‐HT_1C receptors mediate 1–3(chlorophenyl)piperazine‐induced hypophagia

1991 • 150 citations

Effects of benzodiazepines on central serotonergic mechanisms.

1975 • 143 citations

Behavioral and 5-HT antagonist effects of ritanserin: A pure and selective antagonist of LSD discrimination in rat

1985 • 143 citations

Specific binding of 3H-mepyramine to histamine H1 receptors in intestinal smooth muscle

1977 • 141 citations

[3H]-BRL 43694 (granisetron), a specific ligand for 5-HT3 binding sites in rat brain cortical membranes

1989 • 138 citations

The mechanism(s) of action of the benzodiazepines

1981 • 117 citations

LY53857, a selective and potent serotonergic (5-HT2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat.

1983 • 115 citations

Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder

1991 • 114 citations

Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

1989 • 109 citations

Increased food intake in satiated rats induced by the 5-HT antagonists methysergide, metergoline and ritanserin

1988 • 106 citations

The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxiety

1992 • 103 citations

Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects

1991 • 102 citations

Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes.

1989 • 99 citations

5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity

1989 • 96 citations

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

1990 • 96 citations

Evidence that blockade of post-synaptic 5-HT1 receptors elicits feeding in satiated rats

1989 • 92 citations

Effect of metergoline on human anxiety

1985 • 82 citations

Characterization of 5-hydroxytryptamine receptors in rat stomach fundus.

1985 • 82 citations

Tryptamine antagonists and punished behavior.

1974 • 77 citations

Structure of the mouse 5-HT 1c 5-HT 2 and stomach fundus serotonin receptor genes

1992 • 72 citations

Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study

1989 • 70 citations

5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model

1992 • 69 citations

Mechanism of action of the benzodiazepines: behavioral aspect.

1980 • 66 citations

Comparison of the effects of the benzodiazepine midazolam and three serotonin antagonists on a consummatory conflict paradigm

1986 • 57 citations

In vitro studies with ICI 169,369, a chemically novel 5-HT antagonist

1988 • 54 citations

Behavioral pharmacology of antagonists at 5-HT2/5-HT1C receptors

1992 • 52 citations

Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol

1987 • 50 citations

Comparative studies on the anti-punishment effects of chlordiazepoxide, buspirone and ritanserin in the pigeon, Geller-Seifter and Vogel conflict procedures

1990 • 46 citations

Serotonin S2 receptors blockage and generalized anxiety disorders. A double-blind study on ritanserin and lorazepam.

1987 • 40 citations

Mianserin in the treatment of depressive illness and anxiety states in general practice.

1978 • 40 citations

Comparative double‐blind trial of mianserin hydrochloride (Organon GB94) and diazepam in patients with depressive illness.

1978 • 38 citations

Comparison of chlordiazepoxide, methysergide, and cinanserin as modifiers of punished behavior and as antagonists of N,N-dimethyltryptamine.

1972 • 33 citations

Ritanserin in the treatment of generalized anxiety disorders: A placebo‐controlled trial

1988 • 33 citations

Two tests in rats for antianxiety effect of clinically anxiety attenuating antidepressants

1987 • 31 citations

Pharmacological and molecular evidence that the contractile response to serotonin in rat stomach fundus is not mediated by activation of the 5-hydroxytryptamine1C receptor.

1990 • 28 citations

An in vivo model for investigating alpha 1- and alpha 2-receptors in the CNS: studies with mianserin.

1979 • 27 citations

A Controlled Comparative Trial of Mianserin and Diazepam in the Treatment of Anxiety States in Psychiatric Out-Patients

1979 • 27 citations

Serotonin-Influencing Drugs in the Treatment of Panic Disorder

1989 • 27 citations

Role of 5-hydroxytryptamine in amphetamine effects on punished and unpunished behaviour

1983 • 20 citations

The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxiety

1992 • 18 citations

Hypersensitivity to m-chlorophenylpiperazine in a subject with subclinical panic attacks

1990 • 17 citations

Competitive antagonism by recognised 5-HT2 receptor antagonists at 5-HT1C receptors in pig choroid plexus

1991 • 14 citations

Mianserin and doxepin in the treatment of outpatient depression with anxiety.

1983 • 13 citations