A hypothesis for the local control of osteoclast function by Ca2+, nitric oxide and free radicals

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

1989 • 977 citations

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1988 • 887 citations

Marrow stromal stem cells

1988 • 835 citations

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

1990 • 827 citations

Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers

1991 • 690 citations

Ciba Foundation Symposium 117

1987 • 518 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

The discovery of nitric oxide as the endogenous nitrovasodilator.

1988 • 486 citations

The Effect of Calcium-Regulating Hormones and Prostaglandins on Bone Resorption by Osteoclasts Disaggregated from Neonatal Rabbit Bones*

1985 • 419 citations

Detection of superoxide generated by endothelial cells.

1984 • 398 citations

Cellular Biology and Biochemical Mechanism of Bone Resorption

1988 • 383 citations

Increased superoxide anion release from human endothelial cells in response to cytokines.

1986 • 365 citations

Cloning and sequence analysis of a cDNA encoding rat preprocholecystokinin.

1984 • 355 citations

Activation of a Cytosolic ADP-ribosyltransferase by Nitric Oxide-generating Agents

1989 • 349 citations

Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP.

1991 • 307 citations

HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINT

1989 • 290 citations

Free radicals in molecular biology, aging, and disease

1985 • 271 citations

Free radicals in biological systems—a review orientated to inflammatory processes

1987 • 235 citations

Control of Cytosolic Free Calcium in Rat and Chicken Osteoclasts

1989 • 227 citations

Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption.

1990 • 225 citations

Evidence that the Head of Kinesin Is Sufficient for Force Generation and Motility in Vitro

1990 • 225 citations

‘Calcium-activated’ intracellular calcium elevation: A novel mechanism of osteoclast regulation

1989 • 208 citations

Stimulation of osteoclastic bone resorption by hydrogen peroxide

1992 • 206 citations

Free Radicals in Molecular Biology, Aging, and Disease

1985 • 203 citations

Peptides from the calcitonin genes: molecular genetics, structure and function

1988 • 187 citations

Evidence that agonists stimulate bivalent-cation influx into human endothelial cells

1988 • 177 citations

Superoxide anion release by human endothelial cells: Synergism between a phorbol ester and a calcium ionophore

1986 • 165 citations

Evidence that the action of calcitonin on rat osteoclasts is mediated by two G proteins acting via separate post-receptor pathways

1990 • 151 citations

Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALBc 3T3 fibroblasts by a cyclic GMP-independent mechanism

1990 • 149 citations

Calcium regulation in sub-mammalian vertebrates

1980 • 131 citations

Cell Proliferation and Oxidative Stress

1989 • 124 citations

Endothelin inhibits osteoclastic bone resorption by a direct effect on cell motility: implications for the vascular control of bone resorption.

1992 • 122 citations

Intracellular regulation of enzyme secretion from rat osteoclasts and evidence for a functional role in bone resorption.

1990 • 118 citations

Oxygen derived free radicals in osteoclasts: The specificity and location of the nitroblue tetrazolium reaction

1990 • 118 citations

Stimulus-secretion coupling in bovine parathyroid cells. Dissociation between secretion and net changes in cytosolic Ca2+.

1986 • 114 citations

BIOLOGY OF PEPTIDES FROM THE CALCITONIN GENES

1987 • 110 citations

Divalent cations mimic the inhibitory effect of extracellular ionised calcium on bone resorption by isolated rat osteoclasts: Further evidence for a “calcium receptor”

1991 • 95 citations

The Calcitonin Gene Peptides: Biology and Clinical Relevance

1990 • 86 citations

Free radical yields from the homolysis of peroxynitrous acid

1992 • 86 citations

The effect of extracellular calcium elevation on morphology and function of isolated rat osteoclasts

1989 • 77 citations

500-Kilodalton calcium sensor regulating cytoplasmic Ca2+ in cytotrophoblast cells of human placenta.

1990 • 60 citations

Xanthine oxidoreductase is present in human synovium.

1987 • 50 citations

Selective antagonism of calcitonin-induced osteoclastic quiescence (Q effect) by human calcitonin gene-related peptide-(Val8Phe37)

1991 • 46 citations

Localisation of xanthine oxidase to synovial endothelium.

1991 • 44 citations

“Calcium receptors” on eukaryotic cells with special reference to the osteoclast

1990 • 41 citations

A real receptor-operated calcium channel?

1988 • 40 citations

Generation of reactive oxygen metabolites by phagocytosing endothelial cells

1988 • 40 citations

Osteoclast Differentiation

1991 • 40 citations

Is the osteoclast calcium “receptor” a receptor-operated calcium channel?

1992 • 38 citations

The Regulation of Osteoclastic Development and Function

2007 • 37 citations

Intracellular calcium in the control of osteoclast function. II. Paradoxical elevation of cytosolic free calcium by verapamil

1990 • 33 citations

Are Changes in Intracellular Free Calcium Necessary for Regulating Secretion in Parathyroid Cells?

1987 • 26 citations

Activation and inactivation of the osteoclast Ca2+ receptor by the trivalent cation, La3+

1992 • 23 citations

Correlates of osteoclast function in the presence of perchlorate ions in the rat

1991 • 22 citations

Evidence for an immunological and functional relationship between superoxide dismutase and a high molecular weight osteoclast plasma membrane glycoprotein

1991 • 20 citations

Osteoclasts from medullary bone of egg‐laying Japanese quail do not express the putative calcium ‘receptor’

1992 • 10 citations