Comparison of conformation-sensitive gel electrophoresis and single-strand conformation polymorphism analysis for detection of mutations in the BRCA1 gene using optimized conformation analysis protocols

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE.

1991 • 931 citations

Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes.

1993 • 685 citations

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

1994 • 626 citations

Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families.

1988 • 510 citations

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

1995 • 497 citations

Rapid detection of BRCA1 mutations by the protein truncation test

1995 • 317 citations

Polymerase chain reaction amplification products separated on rehydratable polyacrylamide gels and stained with silver.

1989 • 300 citations

Mutations and Polymorphisms in the familial early-onset breast cancer (BRCA1) gene

1996 • 288 citations

Current methods of mutation detection

1993 • 263 citations

Optimization of the single-strand conformation polymorphism (SSCP) technique for detection of point mutations

1993 • 238 citations

Sensitivity of single-strand conformation polymorphism and heteroduplex method for mutation detection in the cystic fibrosis gene

1994 • 190 citations

Screening for mutations by RNA single-strand conformation polymorphism (rSSCP): comparison with DNA-SSCP

1992 • 167 citations

Optimization of single-strand conformation polymorphism analysis in the presence of polyethylene glycol

1997 • 54 citations

Detection of mutations in multi-exon genes: Comparison of conformation sensitive gel electrophoresis and sequencing strategies with respect to cost and time for finding mutations

1997 • 24 citations