MDM2 Amplification, P53 Mutation, and Accumulation of the P53 Gene Product in Malignant Fibrous Histiocytoma

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Malignant fibrous histiocytoma.An Analysis of 200 Cases

1978 • 1,494 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

The Treatment of Soft-tissue Sarcomas of the Extremities

1982 • 1,285 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

1991 • 712 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases

1984 • 513 citations

Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.

1994 • 512 citations

MDM2 gene amplification in metastatic osteosarcoma.

1993 • 340 citations

The tumore suppressor p53

1993 • 336 citations

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

1993 • 321 citations

Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.

1992 • 305 citations

Mechanisms of p53 loss in human sarcomas.

1990 • 273 citations

Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities

1983 • 210 citations

Detection of amplified oncogenes by differential polymerase chain reaction.

1989 • 209 citations

Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene

1986 • 174 citations

Prognostic Implications of p53 Nuclear Overexpression and High Proliferation Index of Ki-67 in Adult Soft-Tissue Sarcomas

1994 • 169 citations

p53 allele losses, mutations and expression in breast cancer and their relationship to clinico‐pathological parameters

1992 • 152 citations

p53 abnormalities in different subtypes of human sarcomas.

1993 • 139 citations

Prospective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft-tissue sarcomas.

1978 • 133 citations

Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53

1993 • 128 citations

Nuclear immunoreaction of p53 protein in soft tissue sarcomas. A possible prognostic factor

1994 • 122 citations

High Incidence of p53 Gene Mutation in Human Ovarian Cancer and Its Association with Nuclear Accumulation of p53 Protein and Tumor DNA Aneuploidy

1992 • 101 citations

Pattern of p53 Gene Mutations in Breast Cancers of Women of the Midwestern United States

1992 • 94 citations

Radiation therapy technique in soft tissue sarcomas of the extremity—policies of treatment at the national cancer institute

1982 • 73 citations

Detection of Epstein-Barr virus sequences in Hodgkin's disease by the polymerase chain reaction.

1991 • 67 citations

Extremity soft tissue sarcomas: Analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher‐grade sarcomas

1989 • 64 citations

Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer

1994 • 54 citations

p53 Gene alterations and p53 protein accumulation in infiltrating ductal breast carcinomas: correlation between immunohistochemical and molecular biology techniques.

1994 • 51 citations

Cytometry and Morphometry of Malignant Fibrous Histiocytoma of the Extremities

1991 • 30 citations

Correlation between p53 mutations and antibody staining in breast carcinoma

1993 • 28 citations