Gallstones: The Present and Future of Medical Dissolution

Clofibrate and Niacin in Coronary Heart Disease

1975 • 1,660 citations

The physicochemical basis of cholesterol gallstone formation in man

1968 • 1,056 citations

Dissolution of Cholesterol Gallstones by Chenodeoxycholic Acid

1972 • 652 citations

Colonic Secretion of Water and Electrolytes Induced by Bile Acids: Perfusion Studies in Man

1971 • 578 citations

Cholesterol Solubility in Bile. EVIDENCE THAT SUPERSATURATED BILE IS FREQUENT IN HEALTHY MAN

1973 • 527 citations

Effects of obesity and caloric intake on biliary lipid metabolism in man.

1975 • 389 citations

Gallbladder Disease in Pima Indians

1970 • 385 citations

Diminished Bile Acid Pool Size in Patients with Gallstones

1970 • 378 citations

Regulation of Cholesterol Metabolism

1970 • 358 citations

Regulation of Cholesterol Metabolism

1970 • 341 citations

Effects of dietary cholesterol on the regulation of total body cholesterol in man

1971 • 321 citations

A Simple Calculation of the Litho-Genic Index of Bile: Expressing Biliary Lipid Composition on Rectangular Coordinates

1973 • 307 citations

DISSOLUTION OF CHOLESTEROL GALLSTONES BY URSODEOXYCHOLIC ACID

1977 • 305 citations

The solubility of cholesterol in aqueous solutions of bile salts and lecithin

1971 • 291 citations

Efficacy and Specificity of Chenodeoxycholic Acid Therapy for Dissolving Gallstones

1973 • 287 citations

Management of Choledocholithiasis

1972 • 272 citations

GALLSTONE DISSOLUTION IN MAN USING CHENODEOXYCHOLIC ACID

1972 • 259 citations

Cholesterol Production in Obesity

1971 • 259 citations

Effects of controlled interruption of the enterohepatic circulation of bile salts by biliary diversion and by ileal resection on bile salt secretion, synthesis, and pool size in the rhesus monkey

1970 • 248 citations

Biliary lipid output during three meals and an overnight fast. I. Relationship to bile acid pool size and cholesterol saturation of bile in gallstone and control subjects.

1975 • 245 citations

Active and Passive Bile Acid Absorption in Man. PERFUSION STUDIES OF THE ILEUM AND JEJUNUM

1974 • 241 citations

Increased Prevalence of Cholelithiasis in Men Ingesting a Serum-Cholesterol-Lowering Diet

1973 • 241 citations

Mechanisms of Lithogenic Bile Formation in American Indian Women with Cholesterol Gallstones

1972 • 235 citations

Bile acid sulfates. I. Synthesis of lithocholic acid sulfates and their identification in human bile

1971 • 224 citations

Induced Alterations in Composition of Bile of Persons Having Cholelithiasis

1971 • 216 citations

ORAL CONTRACEPTIVES AND VENOUS THROMBOEMBOLIC DISEASE, SURGICALLY CONFIRMED GALLBLADDER DISEASE, AND BREAST TUMOURS

1973 • 205 citations

Metabolism of lethocholate in healthy man. I. Biotransformation and biliary excretion of intravenously administered lithocholate, lithocholylglycine, and their sulfates.

1975 • 194 citations

Chenodeoxycholic Acid Treatment of Gallstones

1975 • 194 citations

Gall Stones in Patients with Disorders of the Terminal Ileum and Disturbed Bile Salt Metabolism

1969 • 194 citations

Effects of Clofibrate and of an Estrogen-Progestin Combination on Fasting Biliary Lipids and Cholic Acid Kinetics in Man

1974 • 179 citations

The Enterohepatic Circulation

1972 • 178 citations

Source of Abnormal Bile in Patients with Cholesterol Gallstones

1970 • 176 citations

Studies on the influence of dietary cholesterol on cholesterol metabolism in the isotopic steady state in man.

1965 • 169 citations

Hepatic Cholesterol Metabolism in Patients with Gallstones

1975 • 168 citations

Effect of chenodeoxycholic acid and phenobarbital on the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in patients with gallstones.

1976 • 162 citations

Effect of primary bile acid ingestion on bile acid metabolism and biliary lipid secretion in gallstone patients.

1975 • 161 citations

Duodenoscopic Sphincterotomy and Gallstone Removal

1977 • 160 citations

Some Unique Biologic Characteristics of the Masai of East Africa

1971 • 155 citations

Bile Acid Pools, Kinetics and Biliary Lipid Composition before and after Cholecystectomy

1973 • 151 citations

The quantification of cholesterol excretion and degradation in the isotopic steady state in the rat: the influence of dietary cholesterol

1964 • 146 citations

Effects of Low Dose Chenodeoxycholic Acid Feeding on Biliary Lipid Metabolism

1975 • 142 citations

Lithogenic bile in patients with ileal dysfunction

1972 • 134 citations

The effect of wheat bran upon bile salt metabolism and upon the lipid composition of bile in gallstone patients

1976 • 133 citations

Metabolism of Lithocholate in Healthy Man

1975 • 132 citations

Pigment vs cholesterol cholelithiasis: Clinical and epidemiological aspects

1975 • 132 citations

Gallstones after ileostomy and ileal resection.

1975 • 128 citations

The effect of dietary cholesterol on the composition of human bile.

1973 • 127 citations

Significance of the Liver in the Production of Lithogenic Bile in Man

1970 • 124 citations

Biliary lipid output during three meals and an overnight fast. II. Effect of chenodeoxycholic acid treatment in gallstone subjects.

1975 • 123 citations

Bile acid stimulation of colonic adenylate cyclase and secretion in the rabbit

1976 • 116 citations

The mechanism of increased gallstone formation in obese human subjects.

1976 • 111 citations

Intestinal Digestion and Absorption of Cholesterol and Lecithin in the Human

1969 • 110 citations

Evaluation of Radiographic Lucency or Opaqueness of Gallstones as a Means of Identifying Cholesterol or Pigment Stones

1975 • 108 citations

TRIGLYCERIDE-LOWERING EFFECT OF CHENODEOXYCHOLIC ACID IN PATIENTS WITH ENDOGENOUS HYPERTRIGLYCERIDÆMIA

1974 • 108 citations

Bile Composition at and after Surgery in Normal Persons and Patients with Gallstones

1972 • 105 citations

A catamnestic investigation of Danish twins; a preliminary report.

1956 • 104 citations

Biliary lipid outputs in young women with cholesterol gallstones

1974 • 103 citations

The lithogenic index--a numerical expression for the relative lithogenicity of bile.

1972 • 98 citations

The value of radiology in predicting gallstone type when selecting patients for medical treatment.

1975 • 96 citations

The Lithogenic Index—-A Numerical Expression for the Relative Lithogenicity of Bile

1972 • 93 citations

Serum Lipids in Cholelithiasis: Effect of Chenodeoxycholic Acid Therapy

1973 • 91 citations

Lithocholate metabolism during chemotherapy for gallstone dissolution. 2. Absorption and sulphation.

1976 • 90 citations

Impaired Lithocholate Sulfation in the Rhesus Monkey: A Possible Mechanism for Chenodeoxycholate Toxicity

1976 • 87 citations

Evidence for the absorption of bile acids in the proximal small intestine of normo- and hyperlipidaemic subjects.

1976 • 87 citations

Gallstones in inflammatory bowel disease

1974 • 85 citations

Mechanism of secretion of biliary lipids. I. Role of bile canalicular and microsomal membranes in the synthesis and transport of biliary lecithin and cholesterol.

1975 • 81 citations

The autopsy incidence of gallstones.

1959 • 80 citations

Hepatic Toxicity in the Rhesus Monkey Treated with Chenodeoxycholic Acid for 6 Months: Biochemical and Ultrastructural Studies

1976 • 76 citations

The effect of bile salts upon lecithin synthesis.

1971 • 73 citations

A CATAMNESTIC INVESTIGATION OF DANISH TWINS

1958 • 72 citations

Treatment of Gallstones with Chenodeoxycholic Acid and Phenobarbital

1975 • 71 citations

Alterations in Hepatic Bile Composition After Cholecystectomy

1972 • 70 citations

The Medical Treatment of Cholesterol Gallstones: Experience with Chenodeoxycholic Acid

1976 • 68 citations

Analysis of gallbladder bile in morbid obesity

1975 • 64 citations

The treatment of retained stones in the common bile duct with sodium cholate infusion

1974 • 63 citations

Lithocholate metabolism during chenotherapy for gallstone dissolution. 1. Serum levels of sulphated and unsulphated lithocholates.

1976 • 62 citations

Speed of change in biliary lipids and bile acids with chenodeoxycholic acid--is intermittent therapy feasible?

1977 • 61 citations

Toxicity of chenodeoxycholic acid in the nonhuman primate.

1975 • 60 citations

Effect of varying doses of chenodeoxycholic acid on bile lipid and biliary bile acid composition in gallstone patients: A dose-response study

1977 • 60 citations

Relationship of Bile Acid Pool Size to Biliary Lipid Excretion and the Formation of Litho Genic Bile in Man

1971 • 56 citations

Propranolol Inhibits Bile Acid and Fatty Acid Stimulation of Cyclic AMP in Human Colon

1977 • 53 citations

CLINICAL RELATIONSHIPS OF GALLSTONES

1971 • 49 citations

Increased lithogenicity of bile on fasting in normal subjects

1977 • 43 citations

CHOLIC-ACID TURNOVER AND BILIARY BILE-ACID COMPOSITION IN HUMANS WITH ABNORMAL THYROID FUNCTION. BILE ACIDS AND STEROIDS 139.

1964 • 43 citations

Current status of heparin dissolution of gallstones

1975 • 42 citations

Biliary Lipid Secretion Before and After Cholecystectomy in American Indians with Cholesterol Gallstones

1974 • 41 citations

NON-SURGICAL REMOVAL OF RETAINED BILIARY CALCULI

1971 • 41 citations

Effect of bile acid feeding on cholesterol metabolism in gallstone patients.

1974 • 40 citations

Synthesis of Phospholipids and Triglycerides in Human Liver Slices III. Influence of Bile Acids, Choline, and Linoleic Acid

1972 • 34 citations

Gallstone prevalence and biliary lipid composition in inflammatory bowel disease

1977 • 33 citations

Presence or absence of inhibitors of crystal growth in bile. 1. Effect of bile on the formation of calcium phosphate, a constituent of gallstones.

1976 • 33 citations

The sequential deposition of crystalline material in gallstones: Evidence for changing gallbladder bile composition during the growth of some stones

1974 • 32 citations

Changes in canine bile-flow and composition after vagotomy

1969 • 31 citations

Composition of biliary lipids and kinetics of bile acids after cholecystectomy in man

1976 • 30 citations

Effects of Long Term Feeding of Chenodeoxycholic Acid on Biosynthesis and Metabolism of Bile Acids in the Rat

1974 • 27 citations

Relationship of Biliary Phospholipid and Cholesterol Concentrations to the Occurrence and Dissolution of Human Gallstones

1970 • 27 citations

Inheritance of gall-bladder disease.

1959 • 24 citations

PREVENTION OF CHENODEOXYCHOLIC-ACID TOXICITY WITH LINCOMYCIN

1975 • 23 citations

A scanning electron microscopic study of gallstone development in man.

1974 • 21 citations

Insignificance of the Enterobiliary Circulation of Lecithin in Man

1970 • 21 citations

Feasibility of low-dose and intermittent chenodeoxycholic acid therapy of gallstones

1977 • 20 citations

Studies on calculus versus milieu: gallstone and bile.

1971 • 19 citations

Dissolution of Stones in the Common Bile Duct with Bile‐Salt Solutions¹

1974 • 18 citations

Dissolution of gallstones with bile salts, lecithin, and heparin.

1974 • 18 citations

Criteria for Selection of Patients for Medical Treatment (Chenodeoxycholic Acid Therapy) of Gallstones

1977 • 17 citations

Synthesis of Phospholipids and Triglycerides in Human Liver Slices

1970 • 17 citations

Dissolution of human gallstones: The efficacy of bile salt, bile salt plus lecithin and heparin solutions

1975 • 17 citations

Effect of dietary fibre on gallstone formation in hamsters

1975 • 17 citations

Dietary Cholesterol Affects Chenodeoxycholic Acid Action on Biliary Lipids

1977 • 16 citations

Biliary Lipids during Vitamin C Feeding in Healthy Persons

1975 • 16 citations

The Effect of a Hydrocholeret Agent (Zanchol) on Biliary Lipids in Post Cholecystectomy Patients

1976 • 16 citations

Cheno and Urso: What the Goose and the Bear Have in Common

1975 • 15 citations

Can a Cholesterol-Lowering Diet Cause Gallstones?

1973 • 14 citations

The composition of human gall-stones

1968 • 14 citations

Canine Gallbladder Bile

1975 • 14 citations

EFFECT OF GLYCEROPHOSPHATE ON LITHOGENIC BILE

1974 • 13 citations

Heparin and gallstones

1974 • 13 citations

Gallstone dissolution in vitro by bile acids, heparin, and quanternary amines.

1974 • 13 citations

The effect of phenobarbital on biliary lipid metabolism and hepatic microsomal drug metabolism in patients with cholesterol cholelithiasis

1976 • 12 citations

Gallstone Formation Secondary to a Foreign Body

1971 • 12 citations

Stratification of bile in gallbladder and gallstone formation.

1975 • 11 citations

Cancer: Delay in Its Surgical Treatment

1924 • 9 citations

Cholelithiasis: Familial Predisposition

1952 • 8 citations

Semiquantitative Measurement of Lithocholic Acid Compounds in Bile from Patients with Gallstones, before and during Treatment with Chenodeoxycholic Acid

1976 • 8 citations

Metabolism of Lysolecithin by Rat Small Intestine

1968 • 7 citations

Gastric ulcer and gastritis.

1971 • 5 citations

Rapid feedback inhibition of endogenous cholic and chenodeoxycholic acid synthesis by exogenous chenodeoxycholic acid in man

1975 • 5 citations

Effect of a Hydrocholeretic Agent (Zanchol) on Sterol Metabolism in Rats

1977 • 4 citations