Comparative studies of four monoclonal antibodies to phenylalanine hydroxylase exhibiting different properties with respect to substrate-dependence, species-specificity and a range of effects on enzyme activity

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

Purification with monoclonal antibody of a predominant leukocyte‐common antigen and glycoprotein from rat thymocytes

1979 • 282 citations

A simple purification of phenylalanine hydroxylase by substrate-induced hydrophobic chromatography.

1979 • 191 citations

Substrate activation of phenylalanine hydroxylase. A kinetic characterization.

1980 • 133 citations

Rat Liver Phenylalanine Hydroxylase

1969 • 78 citations

Activation of phenylalanine hydroxylase by phenylalanine

1971 • 56 citations

Genetics of the mammalian phenylalanine hydroxylase system. Studies of human liver phenylalanine hydroxylase subunit structure and of mutations in phenylketonuria

1979 • 42 citations

Functional diversity of antibodies elicited by bacterial beta-D-galactosidase. Monoclonal activating, inactivating, protecting, and null antibodies to normal enzyme.

1980 • 40 citations

Phenylalanine Hydroxylase of Macaca irus

1975 • 30 citations

Isolation and characterization of a myeloma–spleen-cell hybrid producing antibody to phenylalanine hydroxylase

1980 • 24 citations

Genetics of the mammalian phenylalanine hydroxylase system. II. Immunological and two-dimensional gel electrophoretic studies of phenylalanine hydroxylase in cultured normal and mutant rat hepatoma cells

1979 • 20 citations

Observations indicating the nature of the mutation in phenylketonuria

1979 • 15 citations

Isolation of phenylalanine hydroxylase-stimulating monoclonal antibody by rat-myeloma–rat-spleen-cell fusion

1980 • 12 citations