Regulation of Gene Expression by Thyroid Hormones and Retinoic Acid

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

1987 • 1,021 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

1986 • 834 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

Apolipoprotein B-48 Is the Product of a Messenger RNA with an Organ-Specific In-Frame Stop Codon

1987 • 746 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 • 672 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

A new retinoic acid receptor identified from a hepatocellular carcinoma

1988 • 613 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Retinoic acid and thyroid hormone induce gene expression through a common responsive element

1988 • 586 citations

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

1990 • 524 citations

Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer

1989 • 508 citations

Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific

1989 • 493 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

Tissue Differences in the Concentration of Triiodothyronine Nuclear Binding Sites in the Rat: Liver, Kidney, Pituitary, Heart, Brain, Spleen and Testis

1974 • 469 citations

Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing

1989 • 437 citations

Feeding Experiments on tadpoles

1912 • 430 citations

Identification of a Novel Thyroid Hormone Receptor Expressed in the Mammalian Central Nervous System

1987 • 429 citations

Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

1988 • 425 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma

1986 • 399 citations

Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product

1989 • 387 citations

Experimental Production of Congenital Malformations in Mammals by Metabolic Procedure

1959 • 383 citations

Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product

1985 • 368 citations

Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor

1989 • 358 citations

A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone

1987 • 347 citations

Thyroid Hormone Action in Cell Culture: Demonstration of Nuclear Receptors in Intact Cells and Isolated Nuclei

1973 • 337 citations

SPECIFIC NUCLEAR TRIIODOTHYRONINE BINDING SITES IN RAT LIVER AND KIDNEY¹

1972 • 336 citations

Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

1990 • 330 citations

A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.

1989 • 316 citations

A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene.

1989 • 314 citations

Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression.

1982 • 304 citations

A Domain Containing Leucine-Zipper-Like Motifs Mediate Novelin VivoInteractions between the Thyroid Hormone and Retinoic Acid Receptors

1989 • 293 citations

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

1987 • 282 citations

Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells.

1982 • 280 citations

Identification of a Rat c-erbAα-Related Protein Which Binds Deoxyribonucleic Acid but does not Bind Thyroid Hormone

1988 • 254 citations

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

1989 • 251 citations

Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone.

1985 • 245 citations

Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

1991 • 242 citations

A Novel Thyroid Hormone Receptor Encoded by a cDNA Clone from a Human Testis Library

1987 • 242 citations

Spatial distribution of cellular protein binding to retinoic acid in the chick limb bud

1988 • 241 citations

Thyroid Hormone Action IN VITRO CHARACTERIZATION OF SOLUBILIZED NUCLEAR RECEPTORS FROM RAT LIVER AND CULTURED GH1 CELLS

1974 • 229 citations

Retinoic acid. Inhibition of the clonal growth of human myeloid leukemia cells.

1982 • 224 citations

Involvement of the Chox-4 chicken homeobox genes in determination of anteroposterior axial polarity during limb development

1991 • 223 citations

Identification of Nuclear Factors that Enhance Binding of the Thyroid Hormone Receptor to a Thyroid Hormone Response Element

1989 • 219 citations

A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways.

1991 • 217 citations

Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor

1990 • 211 citations

The effect of neonatal thyroidectomy on myelination in the rat brain

1969 • 195 citations

Thyroid hormone modulates the introduction of a stop codon in rat liver apolipoprotein B messenger RNA.

1988 • 191 citations

Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis.

1991 • 189 citations

Thyroid hormone receptors. Binding characteristics and lack of hormonal dependency for nuclear localization

1975 • 182 citations

Regulation of growth hormone messenger RNA synthesis by dexamethasone and triiodothyronine

1985 • 173 citations

Tight Linkage between the Syndrome of Generalized Thyroid Hormone Resistance and the Human c-erbAβ Gene

1988 • 171 citations

Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression

1990 • 139 citations

Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone.

1989 • 129 citations

Liquid-like movements in crystalline insulin

1988 • 129 citations

Evidence for late Proterozoic subduction from 700-Myr-old blueschists in China

1990 • 121 citations

Triiodothyronine enhancement of neuronal differentiation in aggregating fetal rat brain cells cultured in a chemically defined medium

1980 • 118 citations

Effects of Altered Thyroid States on Myelinogenesis

1981 • 118 citations

Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.

1991 • 114 citations

Nuclear Triiodothyronine Receptor Sites in Brain: Probable Identity with Hepatic Receptors and Regional Distribution*

1978 • 113 citations

INFLUENCE OF THYROID ON FORMATION OF MYELIN LIPIDS ¹

1969 • 112 citations

v-erbA Oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action

1991 • 101 citations

Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells.

1989 • 100 citations

Thyroid Hormone Regulation of the Rat Glycoprotein Hormone α-Subunit Gene Promoter Activity

1989 • 99 citations

Thyroid Hormone Receptor Mutations that Interfere with Transcriptional Activation also Interfere with Receptor Interaction with a Nuclear Protein

1991 • 93 citations

EFFECT OF HYPOTHYROIDISM ON IONIC METABOLISM AND Na‐K ACTIVATED ATP PHOSPHOHYDROLASE ACTIVITY IN THE DEVELOPING RAT BRAIN¹

1969 • 90 citations

Cellular retinoic acid-binding protein and the role of retinoic acid in the development of the chick embryo

1989 • 89 citations

Differential binding to soluble nuclear receptors and effects on cell viability of retinol and retinoic acid in cultured retinoblastoma cells

1977 • 85 citations

Transcriptional activation and stabilization of malic enzyme mRNA precursor by thyroid hormone.

1988 • 84 citations

Cellular retinol-binding protein. Quantitation and distribution.

1984 • 81 citations

Novel Retinoic Acid Receptor- Transcripts in Acute Promyelocytic Leukemia Responsive to All-trans-Retinoic Acid

1990 • 80 citations

The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast

1990 • 80 citations

Identification of a novel in-frame translational stop codon in human intestine ApoB mRNA

1987 • 79 citations

Effects of thyroid state on brain development: Muscarinic acetylcholine and GABA receptors

1980 • 77 citations

Thyroid hormone regulates expression of a transfected alpha-myosin heavy-chain fusion gene in fetal heart cells.

1987 • 74 citations

Thyroid Hormones and the Biochemistry of Amphibian Metamorphosis

1967 • 73 citations

3,5,3′-Triiodothyronine Receptor Auxiliary Protein (TRAP) Enhances Receptor Binding by Interactions within the Thyroid Hormone Response Element

1991 • 73 citations

Mapping of a retinoic acid-responsive element in the promoter region of the complement factor H gene

1990 • 72 citations

Photoaffinity labeling of thyroid hormone nuclear receptors. Influence of n-butyrate and analysis of the half-lives of the 57,000 and 47,000 molecular weight receptor forms.

1984 • 70 citations

Binding of Thyroid Hormone Receptors to the Rat Thyrotropin-β Gene

1989 • 63 citations

Biochemical aspects of metamorphosis: transition from ammonotelism to ureotelism.

1966 • 60 citations

Effects of thyroid state on brain development: β-Adrenergic receptors and 5′-nucleotidase activity

1980 • 60 citations

Thyroid Hormone Control of Thyrotropin Gene Expression in Rat Anterior Pituitary Cells*

1987 • 57 citations

Synthesis of Carbamyl Phosphate Synthetase in Amphibian Liver in Vitro

1969 • 49 citations

Development of markers for cholinergic neurones in re‐aggregate cultures of foetal rat whole brain in serum‐containing and serum‐free media: effects of triiodothyronine (T₃)

1984 • 45 citations

Thyroid Hormone Regulation of Thyrotropin α- and β-Subunit Gene Transcription

1985 • 41 citations

Influence of thyroid hormones on myelin proteins in the developing rat brain

1975 • 39 citations

Effect of thyroid hormone and serum on the development of Na2+,K+-adenosine triphosphatase and associated ion fluxes in cultures from rat brain

1985 • 39 citations

Effect of neonatal hypothyroidism and delayed L-triiodothyronine treatment on behavioural activity and norepinephrine and dopamine biosynthetic systems in discrete regions of rat brain

1979 • 35 citations

Induction of a rapidly responsive hepatic gene product by thyroid hormone requires ongoing protein synthesis

1987 • 29 citations

Effect of thyroid status on the development of the different molecular forms of Na+,K+-ATPase in rat brain

1985 • 28 citations

Retinoid receptor antisense DNAs inhibit alkaline phosphatase induction and clonogenicity in malignant keratinocytes.

1989 • 27 citations

Triiodothyronine Rapidly Reverses Inhibition of S14 Gene Transcription by Glucagon*

1988 • 25 citations

Thyroxine regulates the activity and the concentration of synaptic plasma membrane Na,K-ATPase in the developing rat brain cortex

1984 • 23 citations

Stimulatory effect of retinoic acid on GH gene expression: the interaction of retinoic acid and tri-iodothyronine in rat pituitary cells

1990 • 18 citations

Effects of Thyroid Hormones on the Evolution of Monoamine Oxidase Activity in the Brain and Heart of the Developing Rat

1977 • 16 citations

Induction of a rapidly responsive hepatic gene product by thyroid hormone requires ongoing protein synthesis.

1987 • 15 citations

Retinoid binding protein activities in murine embryonal carcinoma cells and their differentiated derivatives.

1983 • 15 citations

Diazepam modifies L-triiodothyronine- stimulated changes in behaviour and the metabolism of brain norepinephrine, dopamine and 5-hydroxytrytamine—A possible mechanism of action

1979 • 11 citations

Wigner's phase-space density

1984 • 2 citations