Unilateral MPTP-Lesioned Monkey as an Animal Model for Parkinson's Disease

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

REACTION TIME IN PARKINSON'S DISEASE

1981 • 512 citations

Hemiparkinsonism in monkeys after unilateral internal carotid artery artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1986 • 309 citations

Biochemical Events in the Development of Parkinsonism Induced by 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine

1987 • 246 citations

MPTP: current concepts and controversies.

1986 • 234 citations

Increased Dopamine Receptor Sensitivity After Estrogen Treatment Using the Rat Rotation Model

1980 • 222 citations

MPTP

1986 • 193 citations

Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP

1987 • 163 citations

Sniffing, rearing and locomotor responses to the D-1 dopamine agonist R-SK&F 38393 and to apomorphine: Differential interactions with the selective D-1 and D-2 antagonists SCH 23390 and metoclopramide

1985 • 158 citations

Evidence for neuromelanin involvement in MPTP-induced neurotoxicity

1987 • 120 citations

Differential effects of D ₁ and D ₂ agonists in MPTP‐treated primates

1990 • 99 citations

Hemiparkinsonism in a monkey after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is associated with regional ipsilateral changes in striatal dopamine D-2 receptor density

1986 • 98 citations

The D1 agonist SKF 38393 inhibits the antiparkinsonian activity of the D2 agonist LY 171555 in the MPTP-treated marmoset

1988 • 65 citations

The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1–methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) and structurally related compounds

1986 • 65 citations

Deficits in reaction times and movement times as correlates of hypokinesia in monkeys with MPTP-induced striatal dopamine depletion

1989 • 62 citations

Stereoselective reversal of MPTP-induced parkinsonism in the marmoset after dermal application of N-0437

1989 • 52 citations

NEUROPEPTIDES AND DOPAMINE IN THE MARMOSET

1986 • 47 citations

Further treatment with MPTP does not produce parkinsonism in marmosets showing behavioural recovery from motor deficits induced by an earlier exposure to the toxin

1989 • 40 citations

Recommended safe practices for using the neurotoxin MPTP in animal experiments.

1988 • 32 citations

Intracarotid 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Administration: Biochemical and Behavioral Observations in a Primate Model of Hemiparkinsonism

1990 • 32 citations

A double‐blind, placebo‐controlled, dose‐ranging study to investigate the safety and efficacy of CY 208‐243 in patients with Parkinson's disease

1989 • 32 citations

Chapter 63 Transplant improves hemiparkinsonian syndrome in nonhuman primate: intracerebral injection, rotometry, tyrosine hydroxylase immunohistochemistry

1988 • 31 citations

N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the monkey: neurochemical pathology and regional brain metabolism.

1986 • 25 citations

Behavioral and biochemical studies in monkeys made hemiparkinsonian by MPTP

1987 • 22 citations

NB-355

1989 • 10 citations

A new device for the quantitative assessment of dopaminergic drug effects in unilateral MPTP-lesioned monkeys

1988 • 8 citations

Pathophysiology and Biochemical Mechanisms Involved in MPTP‐Induced Parkinsonism

1987 • 4 citations

Cholinergic mechanism of acid secretion in the dog: An in vivo and in vitro comparison

1984 • 3 citations