Biosynthesis of Milk Fat

Mechanism of fatty acid synthesis

1961 • 434 citations

MALIC ENZYME AND LIPOGENESIS

1964 • 431 citations

PHOSPHORYLATION COUPLED TO OXIDATION OF DIHYDRODIPHOSPHOPYRIDINE NUCLEOTIDE

1951 • 423 citations

Studies on the mechanism of fatty acid synthesis

1960 • 408 citations

Studies on the Metabolism of Adipose Tissue

1964 • 390 citations

Metabolic Control of Enzymes Involved in Lipogenesis and Gluconeogenesis^*

1964 • 360 citations

A MALONIC ACID DERIVATIVE AS AN INTERMEDIATE IN FATTY ACID SYNTHESIS

1958 • 338 citations

Fatty Acid Synthesis in Adipose Tissue

1961 • 307 citations

Lipoprotein lipase activity of adipose and mammary tissue and plasma triglyceride in pregnant and lactating rats

1970 • 303 citations

Oxygen in the Animal Organism

1964 • 303 citations

The relative significance of acetate and glucose as precursors for lipid synthesis in liver and adipose tissue from ruminants

1967 • 294 citations

Carnitine and derivatives in rat tissues

1967 • 292 citations

Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes

1966 • 285 citations

The role of biotin-dependent carboxylations in biosynthetic reactions

1967 • 283 citations

Evidence for the participation of biotin in the enzymic synthesis of fatty acids

1958 • 282 citations

The Supply of Precursors for the Synthesis of Fatty Acids

1962 • 277 citations

Effect of (—)-Hydroxycitrate on Fatty Acid Synthesis by Rat Liver in Vivo

1971 • 272 citations

The Effect of Palmityl Coenzyme A on Glucose 6-Phosphate Dehydrogenase and Other Enzymes

1966 • 272 citations

Handbook of Physiology, Section 5, Adipose Tissue

1966 • 269 citations

THE BIOSYNTHESIS OF FATTY ACIDS IN RAT LIVER

1957 • 264 citations

Tricarballylate and hydroxycitrate: Substrate and inhibitor of ATP: Citrate oxaloacetate lyase

1969 • 259 citations

Citrate and the Conversion of Carbohydrate into Fat

1970 • 236 citations

Changes in lipid synthesis in rat liver during development

1967 • 230 citations

Acetyl Coenzyme A Carboxylase

1969 • 218 citations

The Purification and Properties of the Fatty Acid Synthetase of Pigeon Liver

1965 • 217 citations

The oxidation and utilization of palmitate, stearate, oleate and acetate by the mammary gland of the fed goat in relation to their overall metabolism, and the role of plasma phospholipids and neutral lipids in milk-fat synthesis

1967 • 200 citations

CITRATE AND THE CONVERSION OF CARBOHYDRATE INTO FAT. THE ACTIVITIES OF CITRATE-CLEAVAGE ENZYME AND ACETATE THIOKINASE IN LIVERS OF STARVED AND RE-FED RATS

1965 • 197 citations

Mode of formation of milk fatty acids from acetate in the goat

1951 • 195 citations

Liver Acetyl Coenzyme A Carboxylase

1968 • 192 citations

Pathways of fatty acid synthesis and reducing equivalent generation in mammary gland of rat, sow, and cow

1970 • 183 citations

Utilization of acetate for milk-fat synthesis in the lactating goat

1951 • 181 citations

Carbohydrate metabolism of mammary tissuf

1958 • 174 citations

THE REQUIREMENT OF TRIPHOSPHOPYRIDINE NUCLEOTIDE IN FATTY ACID SYNTHESIS¹

1955 • 168 citations

Metabolic Roles of Citrate

1967 • 168 citations

Comparative studies of the rat and pigeon liver fatty acid synthetases

1968 • 167 citations

Inhibition of Enzyme Activities by Free Fatty Acids

1968 • 154 citations

Die Synthese verschiedener Carbonsäuren durch den Multienzymkomplex der Fettsäuresynthese aus Hefe und die Erklärung ihrer Bildung

1969 • 154 citations

Availability and Metabolism of Various Substrates in Ruminants. V. Entry Rate into the Body and Incorporation into Milk Fat of d(−)β-Hydroxybutyrate

1969 • 148 citations

Biosynthesis of fatty acids in cell-free preparations. 5. Synthesis of fatty acids from acetate in extracts of lactating-rat mammary gland

1962 • 147 citations

A Study of the Role of Palmityl Coenzyme A in Fatty Acid Synthesis by the Pigeon Liver System

1958 • 146 citations

Studies on the Mechanism of Fatty Acid Synthesis

1968 • 143 citations

Regulation of fatty acid synthesis at the acetyl-CoA carboxylation step

1965 • 142 citations

Biosynthesis of glycerides in subcellular fractions of intestinal mucosa

1961 • 140 citations

The Metabolism of Tritiated Glucose by Rat Adipose Tissue

1966 • 139 citations

Enzymatic Changes Associated with the Initiation and Maintenance of Lactation in the Rat

1966 • 138 citations

Biosynthesis of fatty acids: IV. Studies with inhibitors

1963 • 138 citations

Palmityl-coenzyme a inhibition of the citrate-condensing enzyme

1965 • 137 citations

Comparative biochemical studies of milks—IV. Constituent fatty acids of milk fats

1967 • 136 citations

The intermediary metabolism of the mammary gland. 3. Acetate metabolism of lactating mammary gland slices with special reference to milk fat synthesis

1950 • 135 citations

Studies on the Mechanism of Fatty Acid Synthesis

1968 • 134 citations

Molecular characteristics of liver acetyl CoA carboxylase.

1966 • 134 citations

LIPID SYNTHESIS, INTRACELLULAR TRANSPORT, AND SECRETION

1967 • 129 citations

A modification of the Ellman procedure for the estimation of protein sulfhydryl groups

1967 • 129 citations

Fatty Acid Synthetase from Lactating Rat Mammary Gland

1970 • 126 citations

Lipogenesis in the Ruminant: in vitro Study of Tissue Sites, Carbon Source and Reducing Equivalent Generation for Fatty Acid Synthesis

1972 • 122 citations

The Molecular Physiology of Citrate

1965 • 120 citations

The Relation between Intra- and Extramitochondrial Pyridine Nucleotides

1961 • 117 citations

The Effect of Palmityl Coenzyme A on Pigeon Liver Fatty Acid Synthetase

1968 • 114 citations

The Role of Phosphatidate Phosphohydrolase in Glyceride Biosynthesis

1967 • 113 citations

The Localization of Acyl Coenzyme A-Carnitine Acyltransferases in Rat Liver Cells

1967 • 113 citations

Pathways of Hydrogen Transport in the Oxidation of Extramitochondrial Reduced Diphosphopyridine Nucleotide in Flight Muscle

1962 • 110 citations

Factors involved in synthesis of fatty acids from acetate by a soluble fraction obtained from lactating rat mammary gland

1961 • 109 citations

Quantitative gas-liquid chromatographic analysis of rodent milk triglycerides

1968 • 109 citations

Liver Acetyl Coenzyme A Carboxylase

1968 • 108 citations

Studies on the origin of milk fat. 2. The secretion of dietary long-chain fatty acids in milk fat by ruminants

1956 • 108 citations

Lipid Metabolism

1964 • 107 citations

Triglyceride Structure of Cows’ Milk Fat. I. Preliminary Observations on the Fatty Acid Composition of Positions 1, 2, and 3

1967 • 107 citations

Specific distribution of short-chain fatty acids in molecular distillates of bovine milk fat

1968 • 106 citations

Acetyl CoA carboxylase. I. Requirement for two protein fractions.

1968 • 105 citations

Fatty acid activation and acyl transfer in organs from rats in different nutritional states

1971 • 102 citations

Lactogenesis in the rat. Changes in metabolic parameters at parturition

1967 • 101 citations

Hydrogen transfer in fatty acid synthesis by rat liver and mammary-gland cell-free preparations studied with tritium-labelled pyridine nucleotides and glucose

1963 • 96 citations

Citrate content of liver and kidney of rat in various metabolic states and in fluoroacetate poisoning

1967 • 96 citations

Metabolic adaptations during lactogenesis. Fatty acid and lactose synthesis in cow mammary tissue

1973 • 96 citations

Metabolism of Fatty Acids

1969 • 95 citations

Citrate and the conversion of carbohydrate into fat. A comparison of citrate and acetate incorporation into fatty acids

1964 • 94 citations

Fatty acid biosynthesis V. Purification and characterisation of fatty acid synthetase from lactating-rabbit mammary gland

1970 • 91 citations

The origin of hydrogen in fatty acids formed by lactating rat mammary gland

1963 • 90 citations

Acetyl Coenzyme A Carboxylase: Filamentous Nature of the Animal Enzymes

1969 • 90 citations

LIVER ACETYL COA CARBOXYLASE: THE DISSOCIATION-REASSOCIATION PROCESS AND ITS RELATION TO CATALYTIC ACTIVITY

1966 • 89 citations

SECRETION OF INTRAVENOUSLY ADMINISTERED TRIPALMITIN-1-C14 AND OCTANOATE-1-C14 INTO MILK BY THE LACTATING RAT

1958 • 87 citations

The intracellular distribution of the enzymes catalysing the biosynthesis of glycerides in the intestinal mucosa

1965 • 86 citations

The incorporation of citrate carbon into fatty acids

1963 • 84 citations

The balance of pyridine nucleotides and ATP in adipose tissue.

1966 • 84 citations

Effects of carnitine on acetyl-CoA oxidation by heart muscle mitochondria

1964 • 83 citations

Fat metabolism in higher plants

1966 • 83 citations

Fatty acid synthesis by chain elongation in rat-liver mitochondria

1968 • 79 citations

The Pathway of Hydrogen in Biosyntheses

1961 • 79 citations

Activation of palmityl-CoA:carnitine palmityltransferase in livers from fasted, fat-fed, or diabetic rats

1965 • 78 citations

ACETYL COA CARBOXYLASE, II. DEMONSTRATION OF BIOTIN-PROTEIN AND BIOTIN CARBOXYLASE SUBUNITS

1969 • 77 citations

Studies on the mechanism of fatty acid synthesis XV. Preparation and general properties of β-ketoacyl acyl carrier protein reductase from Escherichia coli

1966 • 76 citations

The Partial Dissociation and the Reassociation of the Pigeon Liver Fatty Acid Synthetase Complex

1967 • 75 citations

The effect of glucose and acetate on milk secretion by the perfused goat udder

1961 • 74 citations

Interrelationships between liver composition, plasma glucose and ketones, and hepatic acetyl-CoA and citric acid during prolonged starvation in the male rat

1968 • 71 citations

Mammary metabolism in lactating sows: arteriovenous differences of milk precursors and the mammary metabolism of [¹⁴C]glucose and [¹⁴C]acetate

1969 • 71 citations

Relative utilization of glucose and acetate carbon for lipogenesis by mammary-gland slices, studied with tritium, 13C and 14C

1954 • 71 citations

The metabolism of acetate and glucose by the isolated perfused udder. 2. The contribution of acetate and glucose to carbon dioxide and milk constituents

1963 • 71 citations

Rat Mammary Acetyl Coenzyme A Carboxylase

1969 • 70 citations

Factors effecting the chain-length of fatty acids synthesized by lactating-rabbit mammary glands

1964 • 70 citations

Effects of insulin and of glycerol in vitro on the incorporation of [carboxy-14C]acetate into the fatty acids of lactating mammary gland slices with special reference to species differences

1952 • 69 citations

The desaturase activity of goat and sow mammary tissue

1970 • 67 citations

The mechanism of synthesis of fatty acids by the pigeon liver enzyme system

1970 • 65 citations

Fatty acid biosynthesis and the role of the acyl carrier protein.

1967 • 65 citations

Desaturation of saturated fatty acids by rat liver microsomes

1970 • 64 citations

Carnitine-coenzyme A transacetylase in mitochondria from various organs

1964 • 63 citations

Enzymatic Activities in Mammary Glands of Several Species

1966 • 63 citations

Steroid influences on respiration, glycolysis, and levels of pyridine nucleotide-linked dehydrogenases of experimental mammary cancers.

1960 • 63 citations

Transferts et synthèse du cholestérol chez le rat au cours de sa croissance

1964 • 62 citations

Stimulation of Biosynthesis of Glyceride

1967 • 62 citations

Structure and Synthesis of Milk Fat. V. A Postulated Sequence of Events from Analyses of Mammary Tissue Lipids

1963 • 62 citations

The relationship of milk phospholipids to membranes of the secretory cell

1971 • 61 citations

Fatty acid biosynthesis

1966 • 61 citations

Fatty Acid Synthetase from Lactating Rat Mammary Gland

1971 • 60 citations

The magnitude and mechanisms of the uptake of milk precursors by the mammary gland

1968 • 60 citations

Factors affecting the chain length of fatty acids synthesised by lactating-rabbit mammary glands

1966 • 60 citations

Enzyme and Metabolite Levels in Mammary and Abdominal Adipose Tissue of Lactating Dairy Cows

1969 • 59 citations

Fatty Acid Synthetase from Lactating Rat Mammary Gland

1971 • 59 citations

The intermediary metabolism of the mammary gland. 1. Respiration of lactating mammary gland slices in presence of carbohydrates

1949 • 58 citations

Studies on the Mechanism of Fatty Acid Synthesis

1968 • 57 citations

Light and Electron Microscopic Radioautography of Lipids: Techniques and Biological Applications

1971 • 56 citations

The fate of acetyl groups derived from glucose in the isolated perfused goat udder

1966 • 55 citations

Pathway for the Synthesis of Fatty Acids in Mammalian Tissues

1972 • 55 citations

Structure and Synthesis of Milk Fat. II. Fatty Acid Distribution in the Triglycerides of Milk and Other Animal Fats

1960 • 55 citations

Citrate and the conversion of carbohydrate into fat. Citrate cleavage in obesity and lactation

1966 • 54 citations

Metabolism of stearate-l-C14 in the isolated cow's udder

1961 • 54 citations

The Effect of Glycerol 3-Phosphate on Fatty Acid Synthesis

1965 • 54 citations

The incorporation of acetate, stearate and <scp>d</scp>(-)-β-hydroxybutyrate into milk fat by the isolated perfused mammary gland of the goat

1967 • 54 citations

Uptake of free fatty acids and chylomicron glycerides by guinea pig mammary gland in pregnancy and lactation

1964 • 53 citations

Specific distribution of fatty acids in the milk fat triglycerides of goat and sheep

1969 • 53 citations

The Role of Carnitine and Carnitine Acyltransferase in Biological Acetylations and Fatty Acid Synthesis

1966 • 52 citations

The Effect of Carnitine on the Rate of Incorporation of Precursors into Fatty Acids

1965 • 52 citations

The pattern of fatty acid synthesis in lactating rabbit mammary gland studied in vivo

1972 • 51 citations

Origin of milk cholesterol in the rat: dietary versus endogenous sources

1966 • 50 citations

The incorporation of [14C3]glycerol into lipids by dispersed bovine mammary cells

1968 • 50 citations

Identification of the sites of binding of acetyl and malonyl groups to the pigeon liver fatty acid synthetase complex

1970 • 50 citations

A QUANTITATIVE BALANCE BETWEEN SUBSTRATES AND METABOLIC PRODUCTS OF THE MAMMARY GLAND

1964 • 50 citations

Fatty Acid Biosynthesis and the Role of the Acyl Carrier Protein1 1This investigation was supported in part by grants from the United States Public Health Service, AM-10550, HE-10406, the National Science Foundation, GB-5056X, GB-5142X, and the American Cancer Society PRA-33.

1967 • 49 citations

Biosynthesis of milk-fat in the rabbit from acetate and glucose. The mode of conversion of carbohydrate into fat

1953 • 47 citations

Levels of enzymes of the direct oxidative pathway of carbohydrate metabolism in the mammary gland of the rat

1953 • 47 citations

Studies on the substrate binding sites of the pigeon liver fatty acid synthetase

1968 • 45 citations

Fatty acid biosynthesis VI. Specificity for termination of fatty acid biosynthesis by fatty acid synthetase from lactating-rabbit mammary gland

1970 • 44 citations

Acetyl-CoA carboxylase and citrate cleavage enzymein the rat mammary gland

1965 • 44 citations

Biosynthesis of short-chain fatty acids in lactating mammary supernatant

1965 • 44 citations

The effects of weaning and milk on mammary fatty acid synthesis

1964 • 43 citations

Estimation of the pentose cycle in the perfused cow's udder

1965 • 43 citations

Primer Specificity of Mammary Fatty Acid Synthetase and the Role of the Soluble β-Oxidative Enzymes

1971 • 42 citations

β-Hydroxybutyrate and Acetate Metabolism of the Perfused Bovine Udder

1959 • 42 citations

Enzymic changes in rabbit and rat mammary gland during the lactation cycle

1969 • 42 citations

Pyridine Nucleotide Requirements of Fatty Acid Synthetases

1971 • 41 citations

Triglyceride synthesis by small-intestinal epithelium of the pig, sheep and chicken

1969 • 41 citations

Utilization of volatile fatty acids in ruminants. IV. Relative activities of acetyl CoA synthetase and acetyl CoA hydrolase in mitochondria and intracellular localization of acetyl CoA synthetase

1972 • 41 citations

Biosynthesis of fatty acids in mammary tissue

1969 • 41 citations

Cholesterol esters of milk and mammary tissue

1970 • 41 citations

The metabolic fate of the products of citrate cleavage. Adenosine triphosphate citrate lyase and nicotinamide–adenine dinucleotide phosphate-linked malate dehydrogenase in foetal and adult liver from ruminants and non-ruminants

1968 • 40 citations

Fatty acid biosynthesis VII. Substrate control of chain-length of products synthesised by rat liver fatty acid synthetase

1970 • 39 citations

Changes in the enzyme pattern of the mammary gland of the lactating rat after hypophysectomy and weaning

1967 • 38 citations

ピオチンの生化学的機能 VIII カルボキシル化アセチル-CoAカルボキミラーゼにおける炭酸結合

1964 • 38 citations

Incorporation of short- and long-chain fatty acids into glycerides by lactating-goat mammary tissue

1964 • 38 citations

Acceptors of fatty acid for glyceride synthesis in guinea pig mammary gland

1964 • 37 citations

Acetyl CoA Carboxylase: The Purified Transcarboxylase Component

1971 • 37 citations

Lactose Synthesis

1958 • 37 citations

Paths of palmitic acid incorporation into milk fat triglycerides

1966 • 37 citations

Comparative biochemistry of fatty acid synthesizing enzyme systems: A review

1972 • 36 citations

Mechanisms of fatty acid synthesis in rat-liver microsomes

1970 • 35 citations

Factors influencing the pattern of fatty acids synthesized by cell-free preparations of lactating rat mammary gland

1967 • 35 citations

Presence of glycerokinase in guinea pig mammary gland and the incorporation of glycerol into glycerides

1964 • 35 citations

The uptake of doubly labeled chylomicrons by guinea pig mammary gland and liver

1964 • 35 citations

Short communications. Chain-length specificity for termination of atty acid biosynthesis by fatty acid synthetase complexes from lactating rabbit mamary gland and rat liver

1970 • 35 citations

Fatty Acid Synthesis in Sheep Mammary Tissue

1973 • 35 citations

Metabolism of DL-1,2-Propanediol-2-14C in a Lactating Cow

1967 • 35 citations

Esterification of glycerol 3-phosphate in lactating guinea-pig mammary gland

1967 • 34 citations

The pathway of hydrogen in biosyntheses. II. Extramitochondrial isocitrate dehydrogenase.

1961 • 34 citations

Rat mammary-gland acetyl-coenzyme A carboxylase. Interaction with milk fatty acids

1970 • 33 citations

Activity Patterns of Several Enzymes of Liver, Adipose Tissue, and Mammary Gland of Virgin, Pregnant, and Lactating Mice.

1966 • 32 citations

Lipid composition and secretory activity of bovine mammary cells in vitro

1968 • 32 citations

Origin of milk cholesterol in the rabbit and guinea pig

1967 • 31 citations

Physicochemical studies of fatty acid synthetase a multienzyme complex from pigeon liver

1965 • 31 citations

Some factors involved in the control of fatty acid synthesis in the lactating bovine mammary gland

1966 • 31 citations

Effect of biotin and avidin on conversion of acetate to fatty acids and acetoacetate by preparations from rat liver and lactating rat mammary gland

1961 • 30 citations

Recent Developments in the Mechanism of Fat Absorption

1963 • 29 citations

Biosynthesis of fatty acids in mammary tissue

1969 • 29 citations

The Uptake of Plasma Lipid and Some Non-Lipid Constituents by the Mammary Gland of the Cow

1964 • 29 citations

Synthesis of milk fat from β-hydroxybutyrate and acetate in mammary tissue in the cow

1969 • 28 citations

Triglyceride synthesis in goat and sow mammary tissue

1971 • 28 citations

Structure and Synthesis of Milk Fat. VIII. Unique Positioning of Palmitic Acid in Milk Fat Triglycerides

1965 • 27 citations

The Pathway of Hydrogen in Biosyntheses

1961 • 27 citations

Metabolism of phospholipid in mammary gland: I. The supply of phospholipid for milk synthesis in the rat and goat

1971 • 26 citations

Characteristics of fatty acid esterification by homogenates of bovine mammary tissue.

1971 • 25 citations

Fatty acid specificity of glyceride synthesis by homogenates of bovine mammary tissue

1971 • 25 citations

Intermediates of fatty acid synthesis: Sites of binding to the pigeon liver fatty acid synthetase

1970 • 25 citations

Pyruvate carboxylase in lactating rat and rabbit mammary gland

1968 • 24 citations

The Action of Pancreatic Lipase on Milk Fat

1960 • 23 citations

Synthesis of milk fat from β-hydroxybutyrate and acetate by ruminant mammary tissue in vitro

1972 • 23 citations

Characteristics of fatty acid esterification by homogenates of bovine mammary tissue

1971 • 22 citations

Fatty acid biosynthesis. IV Properties of acetyl-CoA carboxylase in lactating-rabbit mammary gland

1968 • 21 citations

Incorporation of 14C-labelled fatty acids into the mammary-gland lipids of the lactating rabbit

1965 • 21 citations

Regulation of triglyceride synthesis in the parturient guinea-pig mammary gland

1967 • 21 citations

Position of Endogenous Radioactive Fatty Acids in Mammary Triglycerides

1971 • 21 citations

The component fatty acids of the colostral fat and milk fat of the sow

1966 • 20 citations

Glutamic Acid Metabolism in the Lactating Dairy Cow

1968 • 20 citations

The relationship between milk accumulation and enzyme activities in the involuting rat mammary gland

1969 • 20 citations

Quantitative importance of plasma glucose for synthesis of milk fat glycerol

1961 • 19 citations

Pyruvate carboxylase in lactating rat and rabbit mammary gland

1969 • 19 citations

The uptake of glycerol ethers by the lactating goat mammary gland

1970 • 18 citations

Synthesis of Butyric and Other Short-Chain Acids by a Partially Purified Enzyme Preparation^*

1965 • 17 citations

Incorporation of [1-¹⁴C] and [3-¹⁴C] butyrate into milk constituents by the perfused cow's udder

1960 • 16 citations

Direct Incorporation of β-Hydroxybutyric Acid into Milk Fat Butyric and Hexanoic Acids in Vivo

1966 • 16 citations

Incorporation of Carbon from Acetate and Butyrate into Milk Components

1968 • 16 citations

Fatty acid biosynthesis. VIII. The fate of malonyl-CoA in fatty acid biosynthesis by purified enzymes from lactating-rabbit mammary gland

1971 • 16 citations

Fatty acid biosynthesis. II. Fate of fatty acids synthesised by subcellular fractions of lactating-rabbit mammary gland.

1966 • 14 citations

Fatty acid biosynthesis

1966 • 14 citations

Metabolism of Glycerol by the Mammary Gland

1964 • 8 citations

The metabolism of phospholipids in the lactating mammary gland of the rabbit

1955 • 7 citations

Metabolism of 3H-labelled lactate by rat adipose tissue

1971 • 5 citations

Metabolism of [U-¹⁴C]D-fructose by the isolated perfused udder

1969 • 4 citations

Biosynthesis of fatty acids in cell‐free homogenates of lactating gerbil mammary gland

1969 • 1 citations