Opiates as Immunosuppressive and Genotoxic Agents

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

Surface Modulation in Cell Recognition and Cell Growth

1976 • 1,062 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Binding of HTLV-III/LAV to T4 ⁺ T Cells by a Complex of the 110K Viral Protein and the T4 Molecule

1986 • 988 citations

Acquired Immune Deficiency Syndrome

1983 • 861 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity

1984 • 611 citations

Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes

1979 • 574 citations

Enhancement of natural cytotoxicity by beta-endorphin.

1983 • 457 citations

beta-Endorphin enhances lymphocyte proliferative responses.

1982 • 393 citations

Caffeine-Induced Uncoupling of Mitosis from the Completion of DNA Replication in Mammalian Cells

1986 • 328 citations

Immunologic Dysfunction in Heroin Addicts

1974 • 301 citations

Beta-endorphin and met-enkephalin stimulate human peripheral blood mononuclear cell chemotaxis.

1984 • 292 citations

Risk Reduction for the Acquired Immunodeficiency Syndrome Among Intravenous Drug Users

1985 • 249 citations

The narcotic addict as a medical patient

1968 • 242 citations

Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: in vivo evidence for opiate receptor sites on T lymphocytes.

1980 • 234 citations

Stereoselective muscarinic acetylcholine and opiate receptors in human phagocytic leukocytes

1980 • 223 citations

Opiate receptors on lymphocytes and platelets in man

1983 • 190 citations

The Immune Logical Brain

1987 • 175 citations

The Opium Problem.

1928 • 175 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Homologous Regulation of Gonadotropin-Releasing Hormone Receptors in Cultured Pituitary Cells

1982 • 162 citations

Multiple Opiate Receptors: Alcohol Selectively Inhibits Binding to Delta Receptors

1981 • 150 citations

Acquired immune deficiency syndrome (AIDS) trends in the United States, 1978–1982

1984 • 144 citations

Caffeine

1977 • 133 citations

INGESTED MUTAGENS FROM OPIUM AND TOBACCO PYROLYSIS PRODUCTS AND CANCER OF THE ŒSOPHAGUS

1978 • 115 citations

Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents.

1986 • 107 citations

Phenomenon of human T cells rosetting with sheep erythrocytes analyzed with monoclonal antibodies. "Modulation" of a partially hidden epitope determining the conditions of interaction between T cells and erythrocytes

1982 • 104 citations

Replication bypass model of sister chromatid exchanges and implications for Bloom's Syndrome and Fanconi's anemia

1977 • 103 citations

Ethanol Modulation of Opiate Receptors in Cultured Neural Cells

1983 • 101 citations

Coordinate and independent effects of heroin, cocaine, and alcohol abuse on T-cell E-rosette formation and antigenic marker expression

1986 • 93 citations

Binding of naloxone to human T lymphocytes

1987 • 85 citations

Progress and topics in cytogenetics

1981 • 78 citations

Mechanistic Implications of the Findings That Opiates and Other Drugs of Abuse Moderate T‐Cell Surface Receptors and Antigenic Markers

1987 • 72 citations

Enkephalins—Enhancement of active T-cell rosettes from lymphoma patients

1983 • 69 citations

Opium: A potential urinary bladder carcinogen in man

1979 • 56 citations

Effects of opiates and demographic factors on DNA repair synthesis in human leukocytes.

1979 • 53 citations

Altered T-Lymphocyte Subsets in Hospitalized Intravenous Drug Abusers

1984 • 51 citations

Induction of SCE by opium pyrolysates in CHO cells and human peripheral blood lymphocytes

1983 • 46 citations

Human Chromosomes and Opiates

1972 • 43 citations

Morphine depression of T cell E-rosetting: definition of the process.

1985 • 42 citations

Acquired immune deficiency syndrome (AIDS) trends in the United States, 1978–1982

1984 • 42 citations

Causes of death among institutionalized narcotic addicts

1970 • 41 citations

Infectious Complications of Nonalcoholic Drug Abuse

1974 • 40 citations

Genetic and perinatal effects of abused substances

1987 • 38 citations

Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells

1984 • 37 citations

Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens.

1983 • 31 citations

Marijuana and T Iymphocyte rosettes

1976 • 29 citations

Relationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-rays

1985 • 29 citations

Viral Hepatitis Associated With Illicit Parenteral Use of Drugs

1968 • 28 citations

Effect of caffeine in Fanconi anemia

1988 • 27 citations

Susceptibility of addicts to infection and neoplasia.

1972 • 26 citations

Potentiation of sulphur mustard or cisplatin-induced toxicity by caffeine in Chinese hamster cells correlates with formation of DNA double-strand breaks during replication on a damaged template

1986 • 26 citations

Cytoskeletal involvement in cAMP-induced sensitization of chromatin to nuclease digestion in transformed Chinese hamster ovary K1 cells.

1984 • 25 citations

IMPROVED ALLOGRAFT SURVIVAL OF STRONG IMMUNE RESPONDER-HIGH RISK RECIPIENTS WITH ADJUVANT ANTITHYMOCYTE GLOBULIN THERAPY

1980 • 25 citations

Chromosomes and Neoplasia

1979 • 25 citations

DNA of HeLa Cells during Caffeine-promoted Recovery from X-ray Induced G2 Arrest

1980 • 24 citations

Different modes of action of sodium arsenite, 3-aminobenzamide, and caffeine on the enhancement of ethyl methanesulfonate clastogenicity

1986 • 24 citations

Clastogenic effects of heroin in pregnant monkeys and their offspring

1983 • 23 citations

Effect of post-treatments with caffeine during G₂ on the frequencies of chromosome-type aberrations produced by X-rays in human lymphocytes during G₀ and G₁

1986 • 21 citations

Heroin and Chromosome Damage

1980 • 20 citations

Mechanisms of Synaptic Modulation

1981 • 20 citations

Total and active T cell dynamics in renal allograft recipients.

1976 • 19 citations

Relationship between double strand break rejoining and G2 block formation in V79 cells

1986 • 17 citations

Biogenetic Effects of Opiates

1990 • 16 citations

Parallel increases in sister-chromatid exchanges at base level and with UV treatment in human opiate users

1983 • 15 citations

G2Arrest in Mouse Zygotes after X-irradiation: Reversion by Caffeine and Influence of Chromosome Abnormalities

1988 • 15 citations

A study of deoxyribonucleic acid binding of narcotic analgesics

1975 • 14 citations

Increased rate of E-rosette formation by T lymphocytes of pregnant women who drink ethanol

1984 • 13 citations

Caffeine post-treatment causes a shift in the chromosome aberration types induced by mitomycin C, suggesting a caffeinesensitive mechanism of DNA repair in G2

1988 • 13 citations

Replication Bypass SCE Mechanisms and the Induction of SCE by Single-Strand Adducts or Lesions of DNA

1984 • 9 citations

Potentiation of Induced Sister Chromatid Exchanges and Chromatid-Type Aberrations by Inhibitors of DNA Synthesis and Repair in G2

1984 • 9 citations

A quantitative evaluation of fetal growth failure in a drug-abusing population.

1981 • 7 citations

Opiates as Modulators of Genetic Damage and Immunocompetence

1982 • 4 citations

Opiate inhibition of sheep erythrocyte binding to T lymphocytes: reversal by naloxone and cyclic nucleotides.

1981 • 4 citations