Lymphocytic Choriomeningitis Virus and Immunology

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies

1999 • 895 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex

1975 • 751 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

The production of antibodies

1949 • 526 citations

Virus-specific CD8+ T-cell memory determined by clonal burst size

1994 • 525 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Lymphocytic Choriomeningitis Virus

2016 • 423 citations

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

1998 • 354 citations

The Biology of Lymphocytic Choriomeningitis Infection: Virus-induced Immune Disease

1962 • 309 citations

Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression

1995 • 289 citations

Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System Disease

1972 • 262 citations

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

1986 • 250 citations

On the role of antigen in maintaining cytotoxic T-cell memory.

1996 • 237 citations

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

1991 • 231 citations

A critical role for neutralizing-antibody-producing B cells, CD4⁺T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers

1997 • 202 citations

Lymphocytic Choriomeningitis: Production of Antibody by "Tolerant" Infected Mice

1967 • 200 citations

A non-retroviral RNA virus persists in DNA form

1997 • 178 citations

H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.

1976 • 173 citations

STUDIES ON CELL-MEDIATED IMMUNITY TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN MICE

1973 • 167 citations

Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.

1978 • 166 citations

Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.

1978 • 166 citations

Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice

1977 • 155 citations

Viral persistencein vivothrough selection of neutralizing antibody-escape variants

2000 • 147 citations

PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY

1936 • 144 citations

FACTORS INFLUENCING THE PERSISTENCE OF CHORIOMENINGITIS VIRUS IN THE BLOOD OF MICE AFTER CLINICAL RECOVERY

1938 • 141 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

HISTOCOMPATIBILITY-LINKED GENETIC CONTROL OF DISEASE SUSCEPTIBILITY

1973 • 131 citations

Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without “memory T cells”?

1997 • 131 citations

The Immunodepressive Action of Lymphocytic Choriomeningitis Virus in Mice

1968 • 119 citations

Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice

1999 • 112 citations

Restricted expression of viral glycoprotein in cells of persistently infected mice

1982 • 108 citations

H-2 Compatibility Requirement for Virus-Specific T Cell-Mediated Effector Functions in Vivo

1976 • 99 citations

Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice.

1977 • 96 citations

Virus-triggered immune suppression in mice caused by virus-specific cytotoxic T cells.

1988 • 83 citations

CD4+ T-cell–epitope escape mutant virus selected in vivo

2001 • 80 citations

Susceptibility to murine lymphocytic choriomeningitis maps to class I MHC genes—a model for MHC/disease associations

1985 • 78 citations

The Production of Antibodies

1950 • 78 citations

Inflammatory Process in Murine Lymphocytic Choriomeningitis Is Maximal in H-2K or H-2D Compatible Interactions

1976 • 69 citations

A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria

1999 • 68 citations

THE PROVOCATION OF LATENT LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTIONS IN MICE BY TREATMENT WITH ANTILYMPHOCYTIC SERUM

1968 • 65 citations

Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation

1992 • 64 citations

Viral pathogenesis and resistance to defective interfering particles

1980 • 62 citations

Tissue injury in lymphocytic choriomeningitis viral infection: Virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells

1970 • 61 citations

Antiviral Action of Immune Lymphocytes in Mice Infected with Lymphocytic Choriomeningitis Virus

1972 • 60 citations

STUDIES ON IMMUNOLOGICAL TOLERANCE TO LCM VIRUS

1963 • 57 citations

Temporary presence of self-reactive cytotoxic T lymphocytes during murine lymphocytic choriomeningitis

1975 • 50 citations

Enhancement of disease by neutralizing antiviral antibodies in the absence of primed antiviral cytotoxic T cells

1993 • 42 citations

In vitro primary induction of cytotoxic T cells against virus-infected syngeneic cells

1977 • 27 citations

Major histocompatibility complex-linked susceptibility or resistance to disease caused by a noncytopathic virus varies with the disease parameter evaluated.

1989 • 23 citations

Mechanisms of hemopoietic and immunological dysfunction induced by lymphocytic choriomeningitis virus

1978 • 22 citations

Induction of a primary cytotoxic T cell response to lymphocytic choriomeningitis virus-infected cells in vitro

1977 • 12 citations

Frog ponds and ocean iron

1992 • 8 citations