Design of Small Libraries for Lead Exploration

Pattern Recognition with Fuzzy Objective Function Algorithms

1981 • 16,682 citations

Statistics for Experimenters

1979 • 6,604 citations

Empirical Model Building and Response Surfaces

1988 • 5,297 citations

Substituent constants for correlation analysis in chemistry and biology

1979 • 2,909 citations

Substituent Constants for Correlation Analysis in Chemistry and Biology.

1980 • 2,780 citations

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

1985 • 2,597 citations

A Use's Guide to Principal Components

1991 • 2,416 citations

Empirical Model-Building and Response Surfaces.

1988 • 1,938 citations

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1991 • 1,319 citations

3D QSAR in drug design : theory, methods and applications

2000 • 824 citations

New Chemical Descriptors Relevant for the Design of Biologically Active Peptides. A Multivariate Characterization of 87 Amino Acids

1998 • 640 citations

Chemometric methods in molecular design

1995 • 551 citations

Design and Optimization in Organic Synthesis

1992 • 401 citations

PLS: Partial Least Squares Projections to Latent Structures

1993 • 375 citations

Measuring Diversity: Experimental Design of Combinatorial Libraries for Drug Discovery

1995 • 299 citations

Education reforms struggle against apartheid's legacy

1996 • 275 citations

Computer‐Assisted Lead Finding and Optimization

1997 • 148 citations

A Novel Procedure for the Synthesis of Libraries Containing Small Organic Molecules

1994 • 125 citations

The Prediction of Bradykinin Potentiating Potency of Pentapeptides. An Example of a Peptide Quantitative Structure-activity Relationship.

1986 • 124 citations

Multivariate Parametrization of 55 Coded and Non‐Coded Amino Acids

1989 • 119 citations

Principal Properties for Aromatic Substituents. A Multivariate Approach for Design in QSAR

1989 • 116 citations

Multivariate design

1986 • 101 citations

D‐Optimal Designs in QSAR

1993 • 75 citations

Major components influencing retention indices in gas chromatography

1973 • 67 citations

Multinational drug companies: Issues in drug discovery and development

1989 • 54 citations

Analysis of a 29 Full Factorial Chemical Library

1995 • 47 citations

A New Set of Principal Properties for Heteroaromatics Obtained by GRID

1996 • 36 citations

Scope of Organic Synthetic Reactions. Multivariate Methods for Exploring the Reaction Space. An Example with the Willgerodt-Kindler Reaction.

1987 • 26 citations

Principal Properties for Synthetic Screening: Ketones and Aldehydes.

1988 • 23 citations

Optimum Conditions for the Willgerodt-Kindler Reaction. 3. Amine Variation.

1987 • 19 citations

Principal Properties for Synthetic Screening: Amines.

1988 • 17 citations

Multinational Drug Companies: Issues in Drug Discovery and Development

1989 • 17 citations

A multivariate quantitative structure-activity relationship for corrosive carboxylic acids

1994 • 16 citations

ChemInform Abstract: The Prediction of Bradykinin Potentiating Potency of Pentapeptides.

1986 • 12 citations

On the design of multipositionally varied test series for quantitative structure activity relationships

1987 • 8 citations

ChemInform Abstract: Disjoint Principal Properties of Organic Substituents

1995 • 5 citations

ChemInform Abstract: Optimum Conditions for the Willgerodt‐Kindler Reaction. Part 3. Amine Variation.

1987 • 2 citations