Physiological Effects of Hyperthermia

Thermal dose determination in cancer therapy

1984 • 2,320 citations

The relevance of tumour pH to the treatment of malignant disease

1984 • 886 citations

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1967 • 728 citations

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1967 • 653 citations

THE EFFECT OF TEMPERATURE ON THE pH OF BLOOD AND PLASMA IN VITRO

1948 • 590 citations

Hyperthermic Oncology 1984

1985 • 528 citations

Hyperthermia and Cancer

1982 • 474 citations

Hyperthermia and Cancer

1983 • 426 citations

Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo

1980 • 362 citations

Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

1981 • 339 citations

Selective Heat Sensitivity of Cancer Cells

1977 • 313 citations

Differential response of normal and tumor microcirculation to hyperthermia.

1984 • 308 citations

Hyperthermia in Cancer Therapy.

1983 • 299 citations

Tumor Blood Flow-Characterization, Modifications, and Role in Hyperthermia

1984 • 226 citations

Quantitative measurements of oxygen tension in normal tissues and in the tumours of patients before and after radiotherapy

1960 • 222 citations

The effect of hyperthermia on vascular function, pH, and cell survival.

1980 • 208 citations

TEMPERATURE RANGE AND SELECTIVE SENSITIVITY OF TUMORS TO HYPERTHERMIA: A CRITICAL REVIEW

1980 • 203 citations

Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors

2020 • 202 citations

Effects of hyperthermia on normal and tumor microenvironment.

1980 • 197 citations

31P NMR spectroscopy of in vivo tumors

1982 • 190 citations

Physical aspects of hyperthermia

1982 • 181 citations

Hypoxia in neoplastic tissue

1977 • 176 citations

The biochemical mechanism of selective heat sensitivity of cancer cells

1969 • 174 citations

Alterations in tumor microvasculature during hyperthermia.

1980 • 173 citations

Killing of Chinese hamster cells in vitro by heating under hypoxic or aerobic conditions

1974 • 146 citations

The Influence of Hypoxia and Acidity on the Hyperthermic Response of Malignant CellsIn Vitro

1977 • 142 citations

In vivo ³¹ P NMR study of the metabolism of murine mammary 16/C adenocarcinoma and its response to chemotherapy, x-radiation, and hyperthermia

1983 • 139 citations

Intracapillary oxyhemoglobin saturation of malignant tumors in humans

1981 • 131 citations

Potential for hyperthermia and radiation therapy.

1979 • 128 citations

In vitro-in vivo studies on the susceptibility of the solid Yoshida sarcoma to drugs and hyperthermia (42 degrees).

1974 • 124 citations

Effect of Hyperthermia on Vascular Functions of Normal Tissues and Experimental Tumors: Brief Communication2

1978 • 124 citations

Influence of Extracellular pH on the Viability and Morphology of Tumor Cells Exposed to Hyperthermia

1976 • 122 citations

EFFECT OF HYPERTHERMIA ON VASCULAR FUNCTION IN NORMAL AND NEOPLASTIC TISSUES*

1980 • 121 citations

Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs

1982 • 114 citations

Clinical and biological studies of localized hyperthermia.

1979 • 114 citations

Blood flow in normal tissues and tumors during hyperthermia.

1980 • 112 citations

Physiological mechanisms in hyperthermia: A review

1984 • 110 citations

Total-body hyperthermia versus primary tumor hyperthermia in the treatment of the rabbit VX-2 carcinoma.

1972 • 97 citations

Effects of Hyperglycemia and Hyperthermia on the pH, Glycolysis, and Respiration of the Yoshida Sarcoma In Vivo<xref ref-type="fn" rid="FN2">2</xref>

1979 • 90 citations

Effect of pH on Hyperthermic Cell Survival: Brief Communication 2

1977 • 88 citations

Variations of lipid-protein interactions in erythrocyte ghosts as a function of temperature and pH in physiological and non-physiological ranges

1975 • 88 citations

Intratumoral Vascular Changes With Increased Size of a Mammary Adenocarcinoma: New Method and Results

1965 • 85 citations

The therapeutic advantage of combined heat and X rays on a mouse fibrosarcoma

1978 • 84 citations

31P nuclear magnetic resonance evidence for the regulation of intracellular pH by Ehrlich ascites tumor cells.

1982 • 84 citations

Tumor cell sensitivity to hyperthermia as a function of extracellular and intracellular pH.

1980 • 83 citations

The response of six mouse tumours to combined heat and X rays: implications for therapy

1979 • 82 citations

Erythrocyte membranes undergo cooperative, pH-sensitive state transitions in the physiological temperature range: evidence from Raman spectroscopy.

1976 • 81 citations

Effect of extracellular pH on thermotolerance and recovery of hyperthermic damage in vitro.

1979 • 79 citations

Histopathological study on the effects of hyperthermia on microvasculature

1981 • 76 citations

Physiological effects of hyperthermia: response of capillary blood flow and structure to local tumor heating.

1980 • 75 citations

Quantitative studies of microcirculatory function in malignant tissue: Influence of temperature on microvascular hemodynamics during the early growth of the BA 1112 rat SARCOMA

1979 • 69 citations

Tumor eradication and cell survival after localized hyperthermia induced by ultrasound.

1979 • 69 citations

Modification of Radiosensitivity in Cancer Treatment

1985 • 68 citations

The effects of hyperthermia (42°C) on the biochemistry and growth of a malignant cell line

1972 • 68 citations

Vascular damage and delayed cell death in tumours after hyperthermia

1980 • 66 citations

Regulation of Carbohydrate Metabolism(1985)

2018 • 66 citations

Influence of pH on the thermal sensitivity of cultured human glioblastoma cells.

1981 • 64 citations

Intracellular <italic>p</italic>H of the Ehrlich Ascites Tumor Cell<xref ref-type="fn" rid="FN2">2</xref>

1964 • 63 citations

Hyperthermia-Induced Intracellular Ionic Level Changes in Tumor Cells

1983 • 63 citations

The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow

1984 • 61 citations

Hyperthermia in cancer therapy

1983 • 59 citations

Blood flow and intravascular volume of mammary adenocarcinoma 13726a and normal tissues of rat during and following hyperthermia

1983 • 59 citations

Changes in acidity of mouse tumor by hyperthermia

1984 • 57 citations

Thermal Characteristics of Tumors: Applications In Detection and Treatment

1978 • 57 citations

The Importance of Intratumor Temperature Uniformity in the Study of Radiosensitizing Effects of Hyperthermia in Vivo

1981 • 57 citations

Blood flow, tissue oxygenation, and pH-distribution in malignant tumors upon localized hyperthermia. Basic pathophysiological aspects and the role of various thermal doses.

1983 • 56 citations

Circulatory and metabolic responses of malignant tumors during localized hyperthermia

1980 • 54 citations

Influence of Nutrient and Energy Deprivation on Cellular Response to Single and Fractionated Heat Treatments

1984 • 51 citations

Treating spontaneous tumors in dogs and cats by ultrasound-induced hyperthermia

1978 • 49 citations

Oxygenation of malignant tumors after localized microwave hyperthermia

1982 • 49 citations

TEMPERATURE DISTRIBUTIONS IN NORMAL AND NEOPLASTIC TISSUES DURING NORMOTHERMIA AND HYPERTHERMIA*

1980 • 48 citations

Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an applicable physiological model

1983 • 48 citations

Human tumour pH changes following hyperthermia and radiation therapy

1984 • 48 citations

Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia

1979 • 48 citations

Predictions of blood flow from thermal clearance during regional hyperthermia

1983 • 47 citations

INFLUENCE OF BLOOD SUPPLY ON THERMAL PROPERTIES AND METABOLISM OF MAMMARY CARCINOMAS

1980 • 47 citations

Tumour oxygenation under normobaric and hyperbaric conditions

1983 • 46 citations

Cellular ion content changes during and after hyperthermia

1979 • 45 citations

Blood flow changes in transplanted mouse tumours and skin after mild hyperthermia

1983 • 44 citations

Relationship Between Temperature and Blood Supply or Consumption of Oxygen and Glucose by Rat Mammary Carcinomas

1978 • 44 citations

THE THERMODYNAMIC RELATIONS OF THE OXYGENAND BASE-COMBINING PROPERTIES OF BLOOD

1924 • 42 citations

The sensitivity of a malignant cell line to hyperthermia (42°C) at low intracellular pH

1976 • 38 citations

Good thermal dosimetry is essential to good hyperthermia research

1978 • 38 citations

Aspects of biochemical effects by hyperthermia.

1982 • 38 citations

Micro‐electrode measurement of skin pH in humans during ischaemia, hypoxia and local hypothermia.

1979 • 37 citations

Potentiation of radiation lethality by hyperthermia in a tumor model: Effects of sequence, degree, and duration of heating

1978 • 37 citations

Direct temperature measurement.

1984 • 35 citations

Enhancement of thermal damage to the microcirculation of ‘sandwich’ tumours by additional treatment

1981 • 35 citations

Correlation between Cellular Survival and Potassium Loss in Mouse Fibroblasts after Hyperthermia Alone and after a Combined Treatment with X Rays

1985 • 35 citations

Microwave hyperthermia and its effect on tumor blood flow in rats.

1983 • 33 citations

H+ transport and the regulation of intracellular pH in ehrlich ascites tumor cells

1984 • 31 citations

Thermal distributions in a water bath heated mouse tumor

1985 • 30 citations

Muscle blood flow changes in response to 915 MHz diathermy with surface cooling as measured by Xe133 clearance.

1980 • 29 citations

Blood flow, tissue oxygenation, and pH-distribution in malignant tumors upon localized hyperthermia

1983 • 28 citations

Selective Occlusion of Cancer Tissue Capillaries as the Central Mechanism of the Cancer Multistep Therapy

1980 • 28 citations

Effect of hyperthermia on tumor blood flow

1984 • 28 citations

Evidence for and against a tumor type-specific vascularity.

1986 • 26 citations

Temperature Gradients and Local Perfusion in a Mammary Carcinoma<xref ref-type="fn" rid="fn2">2</xref>

1982 • 25 citations

Anatomical site-specific modalities for hyperthermia.

1984 • 25 citations

INTRACELLULAR PH AND BUFFERING CAPACITY OF THE WALKER-256 CARCINOMA.

1965 • 24 citations

Site dependent response of tumours to combined heat and radiation

1982 • 24 citations

Interstitieller Raum und Mikromilieu in malignen Tumoren

2015 • 22 citations

Biochemical Aspects of Tumour Growth

1980 • 21 citations

Intracapillary oxyhemoglobin saturation in malignant tumours with central or peripheral blood supply

1980 • 20 citations

Effect of Hyperthermia on the Plasma Membrane Structure of Chinese Hamster V79 Fibroblasts: A Quantitative Freeze-Fracture Study

1986 • 20 citations

[Impact of localized microwave hyperthermia on the pH-distribution in malignant tumors (author's transl)].

1982 • 20 citations

Effect of hyperthermia, radiation and adriamycin combinations on tumor vascular function

1982 • 19 citations

Autonomic functions in human physiology

1985 • 19 citations

Amplification of the selective tumor acidification by local hyperthermia

1978 • 18 citations

The effect of reduced pH on the induction of thermotolerance.

1981 • 18 citations

Effect of CO2 and lactic acid on intracellular pH of ascites tumor cells

1981 • 18 citations

Messungen zur irreversiblen Schädigung der Atmung von Krebszellen durch Extremhyperthermie

1966 • 17 citations

A method for interstitial thermoradiotherapy

1985 • 17 citations

Relationship Between Size and Oxygenation Status of Malignant Tumors

1983 • 17 citations

Die manipulierte selektive Hemmung der Mikrozirkulation im Krebsgewebe

1982 • 15 citations

Fibrinogen gel clotting, pH and cancer therapy

1980 • 15 citations

Verstärkung der mit Glukoseinfusion erzielbaren Tumorübersäuerung durch lokale Hyperthermie

1979 • 14 citations

Capillary Blood Flow in Murine Tumors, Feet, and Intestines during Localized Hyperthermia

1983 • 13 citations

Hyperthermia-induced alteration in erythrocyte velocity in tumors.

1983 • 12 citations

Hyperthermia in radiation oncology

1979 • 11 citations

Effects of extracellular calcium on calcium transport during hyperthermia of tumor cells

1985 • 9 citations

A survey of surface hemorheological experiments on the inhibition of fibrinogenin formation employing surface layers of fibrinogen systems with heparins and other substances. A contribution on antithrombogenic action

1984 • 9 citations

Heating of a Rhabdomyosarcoma of the Rat by 2450 MHz Microwaves: Technical Aspects and Temperature Distributions

1986 • 8 citations

Hyperthermia and Cancer

1984 • 8 citations

Effect of Localized Hyperthermia on Tumor Blood Flow and Oxygenation

1984 • 7 citations

Experimental evidence for a hyperthermia-induced breakdown of tumor blood flow during normoglycemia

1983 • 6 citations

Uber den einfluss der hyperthermie auf die verwertung von substraten in ehrlich-aszites-tumorzellen unf kaninchenretikulozyten.

1971 • 2 citations

Hyperthermia

1982 • 1 citations