Severe microvascular injury induced by lysosomal releasates of human polymorphonuclear leukocytes. Increase in vasopermeability, hemorrhage, and microthrombosis due to degradation of subendothelial and perivascular matrices.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

1971 • 513 citations

Role of prostaglandin-mediated vasodilatation in inflammation

1977 • 511 citations

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

1968 • 456 citations

The Neutral Proteases of Human Granulocytes

1973 • 366 citations

Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease.

1977 • 284 citations

Release of Gelatinase from a Novel Secretory Compartment of Human Neutrophils

1982 • 276 citations

Simple Method for Quantitation of Enhanced Vascular Permeability

1970 • 271 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Cytochalasin B: Effect on Lysosomal Enzyme Release from Human Leukocytes

1973 • 243 citations

BOUND COMPLEMENT AND IMMUNOLOGIC INJURY OF BLOOD VESSELS

1965 • 238 citations

Acute Immunologic Pulmonary Alveolitis

1974 • 235 citations

Vascular Injury and Lysis of Basement Membrane in vitro by Neutral Protease of Human Leukocytes

1968 • 211 citations

Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. II. Degradation of isolated bovine nasal cartilage proteoglycan.

1976 • 145 citations

Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens.

1984 • 115 citations

The Extracellular Release of Granulocyte Collagenase and Elastase during Phagocytosis and Inflammatory Processes

1977 • 110 citations

The in vivo quantitation and kinetics of rabbit neutrophil leukocyte accumulation in the skin in response to chemotactic agents and Escherichia coli.

1980 • 106 citations

Mediators of tissue damage in leukocyte lysosomes. X. Further studies on human granulocyte elastase.

1970 • 103 citations

Intracellular and Extracellular Degranulation of Human Polymorphonuclear Azurophil and Specific Granules Induced by Immune Complexes

1974 • 100 citations

Role of neutrophils in the deposition of platelets during acute inflammation.

1983 • 96 citations

A permeability factor released from leukocytes after phagocytosis of immune complexes and its possible role in the Arthus reaction

1964 • 93 citations

The inhibition of phagocytosis and facilitation of exocytosis in rabbit polymorphonuclear leukocytes by cytochalasin B.

1973 • 92 citations

The effect of vasodilator prostaglandins on polymorphonuclear leukocyte infiltration and vascular injury.

1982 • 91 citations

MEDIATORS OF INFLAMMATION IN LEUKOCYTE LYSOSOMES

1966 • 81 citations

The modulation of enhanced vascular permeability by prostaglandins through alterations in blood flow (hyperemia)

1976 • 81 citations

The Role of Lysosomes in Hypersensitivity Reactions: Tissue Damage by Polymorphonuclear Neutrophil Lysosomes

1965 • 80 citations

Allergic inflammation. I. The earliest fine structural changes at the blood-tissue barrier during antigen-antibody interaction.

1963 • 79 citations

Delayed and prolonged vascular leakage in inflammation

1967 • 64 citations

Kinetics of acute inflammation induced by E coli in rabbits. Quantitation of blood flow, enhanced vascular permeability, hemorrhage, and leukocyte accumulation.

1980 • 61 citations

Biopolymer Membrane: A Model System for the Study of the Neutrophilic Leukocyte Response to Immune Complexes

1971 • 59 citations

Demonstration of a kinin-generating enzyme in the lysosomes of human polymorphonuclear leukocytes.

1973 • 58 citations

THE STRUCTURAL BASIS OF INCREASED VASCULAR PERMEABILITY AFTER GRADED THERMAL INJURY‐LIGHT AND ELECTRON MICROSCOPIC STUDIES*

1968 • 58 citations

Enhanced vascular permeability and haemorrhage-inducing activity of rabbit C5ades arg: probable role of polymorphonuclear leucocyte lysosomes.

1980 • 55 citations

The in vivo effect of leukotriene B4 on polymorphonuclear leukocytes and the microcirculation. Comparison with activated complement (C5a des Arg) and enhancement by prostaglandin E2.

1984 • 52 citations

The role of PMN-leukocyte lysosomes in tissue injury, inflammation and hypersensitivity

1966 • 47 citations

Kinetics of acute inflammation induced by Escherichia coli in rabbits. II. The effect of hyperimmunization, complement depletion, and depletion of leukocytes.

1983 • 34 citations

Acute inflammation induced by immune complexes in the microcirculation

1985 • 20 citations

Quantitation of Platelets in the Microcirculation. Measurement of Indium-111 in Microthrombi Induced in Rabbits by Inflammatory Lesions and Related Phenomena

1980 • 16 citations

The Quantitation of Hemorrhage in the Skin. Measurement of Hemorrhage in the Microcirculation in Inflammatory Lesions and Related Phenomena

1980 • 16 citations

Phlogistic Substances in Neutrophil Leukocyte Lyosomes: Their Possible Role in Vivo and their in Vitro Properties

1979 • 4 citations