[All-trans-retinoic acid in the treatment of acute promyelocytic leukemia].

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

1997 • 1,090 citations

A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

1999 • 748 citations

The "Retinoic Acid Syndrome" in Acute Promyelocytic Leukemia

1992 • 709 citations

Effect of all transretinoic acid in newly diagnosed acute promyelocytic leukemia. Results of a multicenter randomized trial. European APL 91 Group

1993 • 521 citations

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase

1998 • 517 citations

Molecular Remission in PML/RARα-Positive Acute Promyelocytic Leukemia by Combined All-trans Retinoic Acid and Idarubicin (AIDA) Therapy

1997 • 492 citations

Presenting White Blood Cell Count and Kinetics of Molecular Remission Predict Prognosis in Acute Promyelocytic Leukemia Treated With All-Trans Retinoic Acid: Result of the Randomized MRC Trial

1999 • 424 citations

A modified AIDA protocol with anthracycline-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML/RARalpha-positive acute promyelocytic leukemia. PETHEMA group.

1999 • 420 citations

A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

1991 • 412 citations

All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship

1990 • 390 citations

Incidence, Clinical Features, and Outcome of AllTrans-Retinoic Acid Syndrome in 413 Cases of Newly Diagnosed Acute Promyelocytic Leukemia

1998 • 334 citations

Early Detection of Relapse by Prospective Reverse Transcriptase-Polymerase Chain Reaction Analysis of the PML/RARα Fusion Gene in Patients With Acute Promyelocytic Leukemia Enrolled in the GIMEMA-AIEOP Multicenter “AIDA” Trial

1998 • 317 citations

Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of leukocytosis, low-dose chemotherapy, PMN/RAR-alpha isoform, and CD13 expression in patients treated with all-trans retinoic acid

1994 • 305 citations

Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia.

1992 • 295 citations

All-trans Retinoic Acid for Acute Promyelocytic Leukemia: Results of the New York Study

1994 • 288 citations

Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome.

2000 • 263 citations

All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Japan Adult Leukemia Study Group [see comments]

1995 • 258 citations

All-transretinoic acid followed by intensive chemotherapy gives a high complete remission rate and may prolong remissions in newly diagnosed acute promyelocytic leukemia: a pilot study on 26 cases

1992 • 240 citations

Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: study of in vitro ATRA sensitivity and cellular retinoic acid binding protein levels in leukemic cells [see comments]

1993 • 191 citations

Experience with gemtuzumab ozogamycin (“mylotarg”) and all-trans retinoic acid in untreated acute promyelocytic leukemia

2002 • 176 citations

Retinoic Acid Syndrome

1998 • 174 citations

Molecular monitoring of the myl/retinoic acid receptor-alpha fusion gene in acute promyelocytic leukemia by polymerase chain reaction

1992 • 173 citations

Additional chromosomal abnormalities in patients with acute promyelocytic leukaemia (APL) do not confer poor prognosis: results of APL 93 trial

2000 • 147 citations

Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience.

1994 • 145 citations

CD56 Expression in Acute Promyelocytic Leukemia: A Possible Indicator of Poor Treatment Outcome?

1999 • 131 citations

Quantitation of minimal residual disease in acute promyelocytic leukemia patients with t(15;17) translocation using real-time RT-PCR

2000 • 130 citations

Treatment of newly diagnosed acute promyelocytic leukemia without cytarabine.

1997 • 130 citations

Leukemic Cellular Retinoic Acid Resistance and Missense Mutations in the PML-RAR Fusion Gene After Relapse of Acute Promyelocytic Leukemia From Treatment With All-trans Retinoic Acid and Intensive Chemotherapy

1998 • 128 citations

Association of PML-RARα Fusion mRNA Type With Pretreatment Hematologic Characteristics But Not Treatment Outcome in Acute Promyelocytic Leukemia: An Intergroup Molecular Study

1997 • 123 citations

The immunophenotype of acute promyelocytic leukemia (APL): an ECOG study.

1994 • 121 citations

Modulation of IL-8, IL-1 beta, and G-CSF secretion by all-trans retinoic acid in acute promyelocytic leukemia.

1994 • 116 citations

Molecular Remissions Induced by Liposomal-Encapsulated All-Trans Retinoic Acid in Newly Diagnosed Acute Promyelocytic Leukemia

1999 • 106 citations

Induction of retinoic acid-binding protein in normal and malignant human myeloid cells by retinoic acid in acute promyelocytic leukemia patients.

1992 • 100 citations

Treatment of relapsing acute promyelocytic leukemia by all-trans retinoic acid therapy followed by timed sequential chemotherapy and stem cell transplantation

2000 • 100 citations

Effectiveness and pharmacokinetics of low-dose all-trans retinoic acid (25 mg/m2) in acute promyelocytic leukemia

1993 • 100 citations

Correlation of CD2 expression with PML gene breakpoints in patients with acute promyelocytic leukemia [see comments]

1992 • 99 citations

Retinoic Acid Induces Aggregation of the Acute Promyelocytic Leukemia Cell Line NB-4 by Utilization of LFA-1 and ICAM-2

1997 • 96 citations

Tretinoin toxicity in children with acute promyelocytic leukaemia

1993 • 92 citations

Extramedullary relapse after all-trans retinoic acid treatment in acute promyelocytic leukemia – the occurrence of retinoic acid syndrome is a risk factor

1999 • 92 citations

Extramedullary Disease in Acute Promyelocytic Leukemia

1999 • 81 citations

Pharmacokinetics of all-trans-retinoic acid administered on an intermittent schedule.

1995 • 81 citations

Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: results from APL 93 trial

2003 • 74 citations

Extramedullary involvement in patients with acute promyelocytic leukemia: a report of seven cases.

1998 • 73 citations

Treatment of Acute Promyelocytic Leukemia: A Report of 70 Cases

1991 • 73 citations

Role of maintenance chemotherapy in acute promyelocytic leukemia

1987 • 72 citations

[Acute promyelocytic leukemia: retrospective study of 119 patients treated with daunorubicin].

1984 • 64 citations

A randomized trial of amsacrine and rubidazone in 39 patients with acute promyelocytic leukemia.

1991 • 60 citations

Proof of differentiative mode of action of all-trans retinoic acid in acute promyelocytic leukemia using X-linked clonal analysis

1992 • 57 citations

Prolonged follow-up confirms that all-trans retinoic acid followed by chemotherapy reduces the risk of relapse in newly diagnosed acute promyelocytic leukemia. The French APL Group [letter]

1994 • 43 citations

Sweet's Syndrome During Treatment with All-Trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

1998 • 42 citations

In vitro all-trans retinoic acid sensitivity of acute promyelocytic leukemia blasts: a novel indicator of poor patient outcome

2001 • 39 citations

Relapsed Acute Promyelocytic Leukemia Previously Treated with All-Trans Retinoic Acid: Clinical Experience with a New Synthetic Retinoid, Am-80

1998 • 35 citations

Clinical study of 9-cis retinoic acid (LGD1057) in acute promyelocytic leukemia

1998 • 34 citations

Erythema nodosum associated with all-trans-retinoic acid in the treatment of acute promyelocytic leukemia.

1993 • 28 citations

Preliminary experience in external quality control of RT-PCR PML-RARα detection in promyelocytic leukemia

1998 • 28 citations

The Thrombophilic State in Acute Promyelocytic Leukemia

1999 • 27 citations

Fournier's gangrene during induction treatment of acute promyelocytic leukemia, a case report

1998 • 25 citations

All-trans retinoic acid induced thrombocytosis in a patient with acute promyelocytic leukaemia.

1997 • 15 citations