Formation of guanoxabenz from guanabenz in human liver. A new metabolic marker for CYP1A2.

Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.

1974 • 1,562 citations

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

Molecular genetics of the P-450 superfamily

1990 • 496 citations

Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

1991 • 340 citations

Human Drug-Metabolizing Enzyme Polymorphisms: Effects on Risk of Toxicity and Cancer

1996 • 336 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

An alternative 7-ethoxyresorufin o-deethylase activity assay: A continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity

1984 • 312 citations

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

1993 • 310 citations

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity

1995 • 271 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis.

1992 • 229 citations

Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

1993 • 214 citations

Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene

1989 • 148 citations

Characterisation of theophylline metabolism by human liver microsomes

1988 • 115 citations

High‐level expression of functional human cytochrome P450 1A2 in Escherichia coli

1992 • 111 citations

Guanabenz A Review of its Pharmacodynamic Properties and Therapeutic Efficacy in Hypertension

1983 • 109 citations

Caffeine as a probe for human cytochromes P450

1992 • 95 citations

Reduced Pyridine nucleotide-dependent N-hydroxy amine oxidase and reductase activities of hepatic microsomes

1973 • 86 citations

Properties of a NADH-dependent N-hydroxy amine reductase isolated from pig liver microsomes

1974 • 78 citations

Cytochrome P450 dependent N-hydroxylation of a guanidine (debrisoquine), microsomal catalysed reduction and further oxidation of the N-hydroxy-guanidine metabolite to the urea derivative

1993 • 65 citations

Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2.

1996 • 63 citations

Determination of human hepatic cytochrome P4501A2 activity in vitro use of tacrine as an isoenzyme-specific probe.

1995 • 52 citations

Isolation and Characterization of the Protein Components of the Liver Microsomal O2-insensitive NADH-Benzamidoxime Reductase

1997 • 52 citations

N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide.

1994 • 51 citations

Microsomal Catalyzed N-Hydroxylation of Guanabenz and Reduction of the N-Hydroxylated Metabolite: Characterization of the Two Reactions and Genotoxic Potential of Guanoxabenz¹

1996 • 43 citations

General pharmacologic actions of the antihypertensive agent 2,6-dichlorobenzylidene aminoguanidine acetate (WY-8678).

1970 • 37 citations

Hepatic microsomal N-hydroxylation of adenine to 6-N-hydroxylaminopurine

1990 • 35 citations

Enzymic and Interindividual Differences in the Human Metabolism of Heterocyclic Amines

1996 • 20 citations

Cytochrome P450-dependentN-hydroxylation of an aminoguanidine (amidinohydrazone) and microsomal retroreduction of theN-hydroxylated product

1994 • 20 citations