Oligodeoxyribonucleotide Phosphorothioate Fluxes and Localization in Hematopoietic Cells

Predicting DNA duplex stability from the base sequence.

1986 • 1,800 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

Characterization of oligonucleotide transport into living cells.

1989 • 739 citations

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

1989 • 510 citations

Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties

1990 • 400 citations

Intracellular distribution of microinjected antisense oligonucleotides.

1991 • 362 citations

Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Oligodeoxynucleotides

1991 • 353 citations

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

1989 • 264 citations

Comparison of Cellular Binding and Uptake of Antisense Phosphodiester, Phosphorothioate, and Mixed Phosphorothioate and Methylphosphonate Oligonucleotides

1993 • 231 citations

Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.

1988 • 227 citations

Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.

1989 • 207 citations

Rapid nuclear accumulation of injected oligodeoxyribonucleotides.

1990 • 157 citations

Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3′‐terminus and their interaction with DNA within mammalian cells

1989 • 147 citations

Inhibition of acquired immunodeficiency syndrome virus by oligodeoxynucleoside methylphosphonates.

1988 • 132 citations

Phosphorothioate and normal oligodeoxyribonucleotides with 5′-linked acridine: characterization and preliminary kinetics of cellular uptake

1988 • 123 citations

Delivery of c-myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic Cells in Culture by Liposome Fusion: Specific Reduction in c-myc Protein Expression Correlates with Inhibition of Cell Growth and DNA Synthesis

1988 • 102 citations

Uptake of Oligodeoxyribonucleotides by Lymphoid Cells Is Heterogeneous and Inducible

1991 • 95 citations

Synthesis of phosphorothioate analogues of oligodeoxyribonucleotides and their antiviral activity against human immunodeficiency virus (HIV)

1988 • 68 citations

Novel activating and capping reagents for improved hydrogen-phosphonate DNA synthesis

1988 • 53 citations

Normal human blood density gradient lymphocyte subset analysis: I. An interlaboratory flow cytometric comparison of 85 normal adults

1985 • 21 citations

Drugs and Minor Groove Binding in B-DNA: Netropsin and Hoechst 33258

1987 • 17 citations

MEETING REPORT: Nucleic Acids as Potential Therapeutics

1991 • 1 citations