Role of mevalonate in regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured cells and their cytoplasts.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters

1974 • 1,571 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

[18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paper

1983 • 1,112 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

Biological Activity of Some Oxygenated Sterols

1978 • 570 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

Familial Hypercholesterolemia: Identification of a Defect in the Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Associated with Overproduction of Cholesterol

1973 • 442 citations

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

1973 • 348 citations

HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO.

1964 • 314 citations

[47] The analysis of nucleic acids in gels using glyoxal and acridine orange

1980 • 266 citations

Regulation of Cholesterol Biosynthesis in Normal and Malignant Tissues* *This research was supported by U. S. Public Health Service Grants CA-08501, CA-05200, and Research Career Award HE-01958, and by the Damon Runyon Memorial Fund Award No. 747.

1970 • 232 citations

New micromethod for measuring cholesterol in plasma lipoprotein fractions.

1977 • 218 citations

Sterol Biosynthesis

1981 • 206 citations

Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.

1983 • 200 citations

Tumor lipids: biochemistry and metabolism

1973 • 186 citations

Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes.

1983 • 156 citations

Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia.

1975 • 148 citations

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

1982 • 147 citations

[12] Enzymes of sterol biosynthesis in liver and intermediates of sterol biosynthesis

1969 • 138 citations

Behaviour of Lipoids in Human Serum

1942 • 129 citations

Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity.

1980 • 118 citations

Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin.

1983 • 117 citations

Improved methods for the solubilization and assay of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1979 • 111 citations

Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo.

1977 • 110 citations

Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts.

1980 • 104 citations

Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein.

1984 • 94 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase in Hepatoma Tissue Culture Cells by Serum Lipoproteins

1974 • 92 citations

The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis.

1984 • 85 citations

Control of sterol synthesis and of hydroxymethylglutaryl CoA reductase in skin fibroblasts grown from patients with homozygous type II hyperlipoproteinemia

1975 • 75 citations

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver.

1983 • 73 citations

Regulation of cholesterol biosynthesis in enucleated cells.

1981 • 67 citations

The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase

1982 • 65 citations

Fractionation of Membrane‐Bound Polysomes, Free Polysomes, and Nuclei from Tissue‐Cultured Cells

1973 • 59 citations

Regulation of vertebrate liver HMG-CoA reductase via reversible modulation of its catalytic activity

1980 • 56 citations

Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B

1978 • 52 citations

Regulation of rat liver phosphoenolpyruvate carboxykinase (GTP) messenger ribonucleic acid activity by N6,O2'-dibutyryladenosine 3',5'-phosphate

1981 • 52 citations

Phenylalanine Hydroxylase in Cultured Hepatocytes

1973 • 50 citations

Osmotic pressures of experimental and human lipaemic sera. Evaluation of albumin-globulin ratios with the aid of electrophoresis

1946 • 30 citations

The effect of feeding cholesterol without fat on the plasma-lipids of the rabbit. The role of cholesterol in fat metabolism

1946 • 30 citations

The osmotic pressure of ‘defatted’ human serum

1943 • 13 citations

Translation of phenylalanine hydroxylase-specific mRNA in vitro: evidence for pretranslational control by glucocorticoids.

1981 • 12 citations