Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for locally advanced head and neck cancer: a clinical and pharmacologic analysis.

A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma.

1987 • 452 citations

Improved complete response rate and survival in advanced head and neck cancer after three-course induction therapy with 120-hour 5-FU infusion and cisplatin

1985 • 392 citations

Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells.

1986 • 374 citations

Cisplatin and 5-fluorouracil infusion in patients with recurrent and disseminated epidermoid cancer of the head and neck

1984 • 262 citations

An analysis of induction and adjuvant chemotherapy in the multidisciplinary treatment of squamous-cell carcinoma of the head and neck.

1987 • 234 citations

Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.

1981 • 195 citations

Continuous ambulatory ECG monitoring during fluorouracil therapy: a prospective study.

1989 • 181 citations

Head and neck cancer: chemotherapy concepts.

1988 • 181 citations

Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.

1986 • 162 citations

Pharmacokinetics of the diastereoisomers of leucovorin after intravenous and oral administration to normal subjects.

1984 • 134 citations

5-Fluorouracil-associated cardiotoxicity

1988 • 121 citations

New vistas for leucovorin in cancer chemotherapy

1989 • 88 citations

Cisplatin, fluorouracil, and high-dose leucovorin for recurrent or metastatic head and neck cancer.

1988 • 75 citations

Cisplatin and 5-FU infusion chemotherapy in advanced, recurrent cancer of the head and neck: an Eastern Cooperative Oncology Group Pilot Study.

1986 • 42 citations

Resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate by chiral high-performance liquid chromatography

1988 • 39 citations

Continuous cisplatin (24-hour) and 5-fluorouracil (120-hour) infusion in recurrent head and neck squamous cell carcinoma

1988 • 31 citations

Toxicity and antitumor activity of 5-fluorouracil in combination with leucovorin. Role of dose schedule and route of administration of leucovorin

1989 • 30 citations

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