Inactivation and Metabolism of Neuropeptides

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

1983 • 2,298 citations

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

1978 • 652 citations

Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates

1976 • 516 citations

[D-Ala ² ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic

1976 • 466 citations

Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase (“enkephalinase”) as neuropeptidase

1981 • 382 citations

Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.

1983 • 374 citations

Neuroleptic activity of the neuropeptide β-LPH62–77 ([Des-Tyr1]γ-endorphin; DTγE)

1978 • 297 citations

Participation of both ‘enkephalinase’ and aminopeptidase activities in the metabolism of endogenous enkephalins

1983 • 140 citations

Enkephalinase: Selective peptide inhibitors

1981 • 135 citations

Inhibition of prolactin secretion by histidyl-proline-diketopiperazine

1978 • 106 citations

Presence in brain of synenkephalin, a proenkephalin-immunoreactive protein which does not contain enkephalin

1983 • 100 citations

Degradation of enkephalins: the search for an enkephalinase

1982 • 93 citations

The metabolic disposition of radiolabeled enkephalins in vitro and in situ.

1978 • 92 citations

Characterization of a nonchymotrypsin-like endopeptidase from anterior pituitary that hydrolyzes luteinizing hormone-releasing hormone at the tyrosyl-glycine and histidyl-tryptophan bonds

1980 • 67 citations

Reaction of Opioid Peptides with Neutral Endopeptidase (‘Enkephalinase”)

1984 • 62 citations

Heterogeneous distribution of enkephalin-degrading peptidases between neuronal and glial cells

1983 • 59 citations

Active Uptake of Substance P Carboxy‐Terminal Heptapeptide (5–11) into Rat Brain and Rabbit Spinal Cord Slices

1981 • 54 citations

Inhibition of enkephalin-degrading enzymes from rat brain and of thermolysin by amino acid hydroxamates

1981 • 44 citations

Localization of the thiorphan‐sensitive endopeptidase, termed enkephalinase A, on glial cells

1983 • 44 citations

Coexistence and corelease of cholinergic and peptidergic transmitters in frog sympathetic ganglia.

1983 • 44 citations

Cleavage of endorphins to des-Tyr endorphins by homogeneous bovine brain aminopeptidase

1980 • 43 citations

Inhibitors of a Rat Brain Enkephalin Aminopeptidase

1982 • 41 citations

Characterization of the site of cleavage of luteinizing hormone-releasing hormone under conditions of measurement in which LHRH degradation undergoes physiologically related change

1982 • 33 citations

Selective participation of both “enkephalinase” and aminopeptidase activities in the metabolism of endogenous enkephalins

1982 • 33 citations

Cellular Localization and Function of the Proteins Encoded by Brain-specific mRNAs

1983 • 22 citations

Accumulation of Thyrotropin Releasing Hormone by Rat Hypothalamic Slices

1984 • 15 citations

The role of the N-terminal sequence in the biological activities of substance P.

1982 • 8 citations