Biochemical and Pharmacological Characterization of YM-60828, a Newly Synthesized and Orally Active Inhibitor of Human Factor Xa

The Determination of Enzyme Dissociation Constants

1934 • 11,865 citations

The contribution of bovine Factor V and Factor Va to the activity of prothrombinase.

1979 • 592 citations

Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa

1990 • 414 citations

Basic Mechanisms in Blood Coagulation

1975 • 366 citations

Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile

1993 • 189 citations

Effects of the Synthetic Thrombin Inhibitor Argatroban on Fibrin- or Clot-Incorporated Thrombin: Comparison with Heparin and Recombinant Hirudin

1994 • 157 citations

DX-9065a, a New Synthetic, Potent Anticoagulant and Selective Inhibitor for Factor Xa

1994 • 156 citations

Importance of factor Xa in determining the procoagulant activity of whole-blood clots.

1993 • 153 citations

Hirudin interruption of heparin-resistant arterial thrombus formation in baboons

1991 • 139 citations

Comparison of the In Vivo Anticoagulant Properties of Standard Heparin and the Highly Selective Factor Xa Inhibitors Antistasin and Tick Anticoagulant Peptide (TAP) in a Rabbit Model of Venous Thrombosis

1991 • 107 citations

Characterization of recombinant tick anticoagulant peptide. A highly selective inhibitor of blood coagulation factor Xa.

1990 • 104 citations

DX-9065a, an Orally Active, Specific Inhibitor of Factor Xa, Inhibits Thrombosis without Affecting Bleeding Time in Rats

1995 • 103 citations

DX 9065A a novel, synthetic, selective and orally active inhibitor of factor Xa: in vitro and in vivo studies.

1996 • 101 citations

Localization of von Willebrand Factor and Thrombin-Interactive Domains on Human Platelet Glycoprotein Ib

1990 • 98 citations

Antithrombotic efficacy of recombinant tick anticoagulant peptide. A potent inhibitor of coagulation factor Xa in a primate model of arterial thrombosis.

1991 • 83 citations

Species differences in anticoagulant and anti-Xa activity of DX-9065a, a highly selective factor Xa inhibitor

1995 • 71 citations

Antithrombotic Effects of Orally Active Synthetic Antagonist of Activated Factor X in Nonhuman Primates

1995 • 57 citations

Effects of DX-9065a, an Orally Active, Newly Synthesized and Specific Inhibitor of Factor Xa, against Experimental Disseminated Intravascular Coagulation in Rats

1994 • 56 citations

Primary Prevention of Coronary Arterial Thrombosis with the Factor Xa Inhibitor rTAP in a Canine Electrolytic Injury Model

1995 • 38 citations

Pharmacological assessment of the antithrombotic activity of the peptide thrombin inhibitor, D-methyl-phenylalanyl-prolyl-arginal (GYKI-14766), in a canine model of coronary artery thrombosis.

1992 • 29 citations