Interleukin 2 expression by tumor cells alters both the immune response and the tumor microenvironment.

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype

1975 • 1,743 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2.

1986 • 534 citations

Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

1981 • 339 citations

Primary radiotherapy of larynx and pharynx carcinoma—An analysis of some factors influencing local control and survival

1986 • 241 citations

Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.

1988 • 225 citations

Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.

1993 • 223 citations

Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide]: analysis of drug adducts by fluorescent antibodies vs bound radioactivity

1995 • 181 citations

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

1985 • 178 citations

The use of fluorescent probes to identify regions of transient perfusion in murine tumors

1989 • 173 citations

Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells.

1973 • 140 citations

Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]

1995 • 118 citations

Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth.

1993 • 91 citations

Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. III. Clonal analysis of the syngeneic cytolytic T lymphocyte response

1982 • 89 citations

Adenosine inhibits the adhesion of anti-CD3-activated killer lymphocytes to adenocarcinoma cells through an A3 receptor.

1994 • 86 citations

Application of an Image Analysis System to the Quantitation of Tumor Perfusion and Vascularity in Human Glioma Xenografts

1995 • 79 citations

Natural killer‐cell activity under conditions reflective of tumor micro‐environment

1991 • 72 citations

Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.

1996 • 68 citations

Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation

1992 • 68 citations

Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.

1991 • 62 citations

Effects of hypoxia on interleukin-2 mRNA expression by T lymphocytes

1994 • 62 citations

Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts

1996 • 61 citations

Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis.

1977 • 60 citations

The closest-individual method in the analysis of the distribution of capillaries

1982 • 57 citations

Mathematical modelling of oxygen supply and oxygenation in tumor tissues: Prognostic, therapeutic, and experimental implications

1988 • 44 citations

Lymphocytic infiltration and cytotoxicity under hypoxic conditions in the EMT6 mouse mammary tumor

1990 • 39 citations

Role of oxygen in T cell-mediated cytolysis.

1982 • 32 citations

Interleukin-2 induces corneal neovascularization in A/J mice.

1990 • 31 citations

Vascular morphometry of KHT and RIF-1 murine sarcomas

1993 • 30 citations

Response of microvascular endothelial cells to biological response modifiers

1989 • 28 citations

Investigation of Interleukin 2 Receptors on Human Endothelial Cells

1991 • 27 citations

Transfection of Transforming Growth Factor-β Producing Tumor EMT6 with Interleukin-2 Elicits Tumor Rejection and Tumor Reactive Cytotoxic T-Lymphocytes

1994 • 26 citations

Neurotoxicity induced by interleukin-2: Involvement of infiltrating immune cells

1996 • 23 citations

Interleukin-2 acutely induces protein leakage from the microcirculation

1991 • 21 citations